D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum
Frontiers in Microbiology, 2018 In mammals, D-Ser is synthesized by serine racemase (SR) and degraded by D-amino acid oxidase (DAO). D-Ser acts as an endogenous ligand for N-methyl-D-aspartate (NMDA)- and δ2 glutamate receptors, and is involved in brain functions such as learning and ...
Tomokazu Ito +7 more
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When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment [PDF]
, 2016 Sensing environmental stimuli is critically important for bacteria when faced with the multitude of adversities presented within the host. Responding appropriately to these signals and in turn integrating these responses into the regulatory network of ...
Connolly, James P.R., Roe, Andrew J.
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Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers. [PDF]
PLoS ONE, 2014 The imbalance of blood and urine amino acids in renal failure has been studied mostly without chiral separation. Although a few reports have shown the presence of D-serine, an enantiomer of L-serine, in the serum of patients with severe renal failure, it
Jumpei Sasabe +9 more
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Iterative focused screening with biological fingerprints identifies selective Asc-1 inhibitors distinct from traditional high throughput screening [PDF]
, 2017 N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and ...
Amoss, Adam +18 more
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D-serine and serine racemase are associated with PSD-95 and glutamatergic synapse stability
Frontiers in Cellular Neuroscience, 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. It is crucial for synaptic plasticity and is implicated in schizophrenia.
Hong eLin +6 more
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Crystalline d-Serine Dehydrase
Journal of Biological Chemistry, 1966 Abstract A procedure is described for the preparation of crystalline d-serine dehydrase from mutant C6 of Escherichia coli K-12, a constitutive mutant for this enzyme. The molecular weight is 37,300, and 1 mole of pyridoxal 5-phosphate is bound per mole of enzyme.
R, Labow, W G, Robinson
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D-Serine reflects kidney function and diseases [PDF]
Scientific Reports, 2019 AbstractD-Amino acids, long-term undetected enantiomers of L-amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early ...
Atsushi Hesaka +8 more
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Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice [PDF]
, 2016 NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported.
Jaaro Peled, Hanna +3 more
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Structure-function relationships in human D-amino acid oxidase. [PDF]
, 2015 5Since D-amino acids were identified in mammals, D-serine has been one of the most extensively studied ‘‘unnatural amino acids’’. This brain-enriched transmitterlike molecule plays a pivotal role in the human central nervous system by modulating the ...
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D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology
Neurology Research International, 2012 In mammalian systems, D-serine is perhaps the most biologically active D-amino acid described to date. D-serine is a coagonist at the NMDA-receptor, and receptor activation is dependent on D-serine binding. Because D-serine binding dramatically increases
John P. Crow +2 more
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