Results 81 to 90 of about 6,867,240 (296)

Specific degradation of photosystem II D1 protein by a protease (Alr3815) in heterocysts of the cyanobacterium Anabaena sp PCC7120

, 2011
Some filamentous cyanobacteria form heterocysts under conditions lacking combined nitrogen for nitrogen fixation. Photosystem II is removed from heterocyst during the process of cell differentiation.
Zhao, JD, Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Genet Engn, Beijing 100871, Peoples R China, Zhao JinDong, Yang GuoHua, Hu Bin, jzhao@pku.edu.cn   +4 more
core  

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability. [PDF]

Elife, 2023
Lu K, Zhang M, Wei G, Xiao G, Tong L, Chen D.   +5 more
europepmc   +1 more source

A Bacterial Transgene for Catalase Protects Translation of D1 Protein during Exposure of Salt-Stressed Tobacco Leaves to Strong Light[OA]

Plant Physiology, 2007
During photoinhibition of photosystem II (PSII) in cyanobacteria, salt stress inhibits the repair of photodamaged PSII and, in particular, the synthesis of the D1 protein (D1).
Khaled Al-Taweel, T. Iwaki, Y. Yabuta, S. Shigeoka, N. Murata, A. Wadano   +5 more
semanticscholar   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Role of protein kinase D1 in pancreatic cancerogenesis

, 2021
The aim of this study was to characterize the effect of Protein Kinase D1 (PKD1) loss in an oncogenic KRASG12D-driven genetic mouse model of pancreatic cancer in vivo. We evaluated three mouse lines (p48-KRASG12D, p48-KRASG12D-PKD1−/− and p48-PKD1−/−) for cancer progression over a period of one year and detected a significant reduction of overall ...
openaire   +1 more source

G870A Polymorphic Variants of CCND1 Gene and Cyclin D1 Protein Expression as Prognostic Markers in Laryngeal Lesions. [PDF]

Diagnostics (Basel), 2022
Kowalczyk MM, Barańska M, Fendler W, Borkowska EM, Kobos J, Borowiec M, Pietruszewska W.   +6 more
europepmc   +1 more source

Role of ROC1 protein in the control of cyclin D1 protein expression in skin melanomas

, 2011
A decrease in the level of the ROC1 protein, which is involved in cyclin D1 degradation, might explain an increase in cyclin D1 protein in the absence of gene overexpression.
Marques, Mariângela, Nai, Gisele [UNESP], Nai, Gisele, Gisele Nai, Mariângela Marques, Marques, Mariângela Esther Alencar, Marques, Mariângela Esther Alencar [UNESP]   +6 more
core   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source