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Research Progress and Clinical Significance of D2-40 in Gastric Cancer
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D2-40 immunoreactivity in penile squamous cell carcinoma: a marker of aggressiveness
D2-40 immunohistochemical expression was investigated in tissue specimens from 39 patients with squamous cell carcinoma of the penis who underwent partial or total penectomy between 1987 and 2008. Patient age, tumor size, and grade; D2-40-positive lymphatic vessel density in intratumoral, peritumoral, and normal tissue; cell positivity for D2-40 in ...
Daniele, Minardi +10 more
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Lymphatic vessels in human sural nerve: immunohistochemical detection by D2-40.
Lymphatics were detected in the epineurium of the human sural nerve by D-240 immunostaining and confirmed by ultrastructural examination.
Volpi Nila +6 more
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D2-40 Immunohistochemistry—So Far!
Advances in Anatomic Pathology, 2009D2-40 is a commercially available monoclonal antibody directed against human podoplanin, a transmembrane mucoprotein that is expressed in lymphatic endothelial cells. Since its introduction, D2-40 immunoexpression has been described in a variety of lymphovascular neoplasms including lymphangioma, Kaposi sarcoma, and hemangioendothelioma, as well as ...
Alexandra N, Kalof, Kumarasen, Cooper
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D2-40: A Reliable Marker in the Diagnosis of Pleural Mesothelioma
Pathobiology, 2006<i>Objective:</i> Malignant mesotheliomas of the pleura, peritoneum and pericardium can easily be confused with either metastatic adenocarcinomas or reactive pleural lesions. D2-40, a monoclonal antibody used as a marker for seminomatous germ cell tumours and lymphatic endothelial cells, was recently described in mesothelial cells and type ...
Annette M, Müller +2 more
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Retiform hemangioendothelioma: presentation of a case expressing D2‐40
Journal of Cutaneous Pathology, 2009Retiform hemangioendothelioma (RH) is a low‐grade angiosarcoma with low metastatic risk, usually occurring as a single lesion on the trunk or extremity in middle‐aged adults. Histopathology shows a distinctive pattern with arborizing blood vessels arranged in a retiform pattern (similar to rete testis tissue) and focal papillae with fibrosclerotic ...
Michael, Emberger +3 more
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Cutaneous Immunoreactivity of D2-40 Antibody Beyond the Lymphatics
The American Journal of Dermatopathology, 2007Recent research suggests that the D2-40 monoclonal antibody recognizes the 40,000 Da O-linked sialoglycoprotein podoplanin. Podoplanin not only is highly expressed in lymphatic endothelium but also in other cell types, including sebaceous carcinoma cells. Using the D2-40 antibody, our purpose was to evaluate expression of podoplanin in sebaceous glands
Amal H A, Gomaa, Mina, Yaar, Jag, Bhawan
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