Results 1 to 10 of about 14,932 (136)

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation. [PDF]

Adv Sci (Weinh)
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Dai H, Zhang XM, Zhang JC, Deng XT, Liu Q, Ali MH, Yin FZ, Yin W.   +7 more
europepmc   +2 more sources

Revolutionizing Drug Delivery: The Power of Ultrasound in Ameliorative Effects of Functionalized Single-Walled Carbon Nanotube Encapsulated Dacarbazine in a Murine B16F10 Melanoma Model [PDF]

Advanced Biomedical Research
Background: The field of drug delivery has witnessed remarkable advancements aimed at optimizing therapeutic outcomes and reducing adverse effects. In this study, we examined the ameliorative effect of ultrasound waves in combination with Functionalized ...
Moghadaseh Mahdinejad, Mohammad Bagher Tavakoli, Azade Taheri, Fateme Heidari, Seyed Hossein Hejazi, Tahereh Komeili Movahed, Hadi Nasrollahi   +6 more
doaj   +2 more sources

The ultrasound wave enhanced carbon nanotube encapsulated dacarbazine effect on melanoma cell death via ER stress-mediated apoptosis [PDF]

Journal of Education and Health Promotion
BACKGROUND: In this study regarding the unique properties of carbon nanotubes (CNTs) to improve drug solubility, stability, and cellular uptake, combined with the mechanical effects of ultrasound wave, we aimed to elucidate how this synergistic approach ...
Moghadaseh Mahdinejad, Mohammad Bagher Tavakoli, Azade Taheri, Hossein Hejazi, Tahereh Komeili Movahed, Fatemeh Heidari, Saeed Kermani, Hadi Nasrollahi   +7 more
doaj   +2 more sources

Extended therapeutic efficacy of dacarbazine following prior treatment with immune checkpoint inhibitors in metastatic melanoma: a single center retrospective study in Korea [PDF]

Journal of Yeungnam Medical Science
Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced malignant melanoma. This study examined the real-world efficacy of dacarbazine (dimethyl triazeno imidazole carboxamide, DTIC) in patients who had previously ...
Jihyun Na, Jun Young Kim, Seok-Jong Lee, In Hee Lee, Soo Jung Lee   +4 more
doaj   +2 more sources

Pogostone effect on dacarbazine-induced autophagy and apoptosis in human melanoma cells [PDF]

World Cancer Research Journal, 2023
Objective: Chemotherapy is effective for treating malignant melanoma, but drug resistance and occurrence of side effects limited this strategy. The balance between autophagy and apoptosis has an essential role in the chemotherapy of cancers.
A. Ghanbari, C. Jalili, I. Rashidi, H. Toranj, F. Raissi, F. Mazini, N. Akhshi   +6 more
doaj   +1 more source

Evaluation of Ultrasound-mediated Chemotherapy Treatment Using Dacarbazine on B16F10 Melanoma Cell Line [PDF]

مجله دانشکده پزشکی اصفهان, 2022
Background: The use of chemotherapy drugs in combination with ultrasound exposure increases their synergic effect at lower doses. It can play an important role in the treatment of drug-resistant cancers, such as melanoma.
Arman Esmailzadeh, Ahmad Shanei, Neda Attaran, Seyed Hossein Hejazi, Simin Hemati   +4 more
doaj   +1 more source

LncRNA POU3F3 Contributes to Dacarbazine Resistance of Human Melanoma Through the MiR-650/MGMT Axis

Frontiers in Oncology, 2021
Background: Alkylating agents are critical therapeutic options for melanoma, while dacarbazine (DTIC)-based chemotherapy showed poor sensitivity in clinical trials. Long non-coding RNAs (lncRNAs) were highlighted in the progression of malignant tumors in
Kai Wu, Qiang Wang, Qiang Wang, Yu-Lin Liu, Zhuo Xiang, Qing-Qing Wang, Li Yin, Shun-Li Liu   +7 more
doaj   +1 more source

The Impact of O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine

Cells, 2023
Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS). Alkylating agents are subjected to resistance mechanisms based on anti-apoptotic pathways and repair mechanisms, including the DNA repair enzyme O6-methylguanine-DNA ...
Lucia Cannella, Rosa Della Monica, Antonella Lucia Marretta, Domenico Iervolino, Bruno Vincenzi, Anna Rosaria De Chiara, Ottavia Clemente, Michela Buonaiuto, Maria Luisa Barretta, Annabella Di Mauro, Massimiliano Di Marzo, Michele Guida, Giuseppe Badalamenti, Lorenzo Chiariotti, Salvatore Tafuto   +14 more
doaj   +1 more source

Focal adhesion alterations in G0‐positive melanoma cells

Cancer Medicine, 2023
Background Melanoma is a highly heterogeneous malignant tumor that exhibits various forms of drug resistance. Recently, reversal transition of cancer cells to the G0 phase of the cell cycle under the influence of therapeutic drugs has been identified as ...
Alexandra R. Esimbekova, Nadezhda V. Palkina, Ivan S. Zinchenko, Vasiliy D. Belenyuk, Andrey A. Savchenko, Ekaterina Yu Sergeeva, Tatiana G. Ruksha   +6 more
doaj   +1 more source

Transcriptomic Profiling Revealed Plexin A2 Downregulation With Migration and Invasion Alteration in Dacarbazine-Treated Primary Melanoma Cells

Frontiers in Oncology, 2021
Melanoma is highly heterogeneous type of malignant neoplasm that is responsible for the majority of deaths among other types of skin cancer. In the present study, we screened a list of differentially expressed genes in two primary, drug-naïve melanoma ...
Anna Tyumentseva, Anna Tyumentseva, Anton Averchuk, Nadezhda Palkina, Ivan Zinchenko, Anton Moshev, Andrey Savchenko, Tatiana Ruksha   +7 more
doaj   +1 more source