Results 31 to 40 of about 17,734 (168)

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age [PDF]

, 2018
Dacarbazine is commonly administered for the treatment of cancers prevalent in reproductive age females. However, investigations of off-target effects of dacarbazine on the ovary are limited.
Karla J. Hutt, Urooza Sarma, Seng H. Liew, Sarma, Urooza, Winship, Amy L., Bakai, Monika, Amy L. Winship, Monika Bakai, Liew, Seng H., Hutt, Karla J.   +9 more
core   +1 more source

Determination of a pain substance produced by the photodegradation of dacarbazine [PDF]

, 2001
The anticancer drug, dacarbazine, is known to be photosensitive, and its photodegradation products have been pointed out as the causes of side effects including local venous pain of injection site.
Matsushita, Ryo, Mukai, Chisato, Miyamoto, Kenichi, Ichimura, Fujio, Kawahara, Masami, Ishida, Tomoyuki, Hanaoka, Miyoji, Kataoka, Osamu, Ishizaki, Junko, Emoto, Chie   +9 more
core   +2 more sources

Co-Delivery of Eugenol and Dacarbazine by Hyaluronic Acid-Coated Liposomes for Targeted Inhibition of Survivin in Treatment of Resistant Metastatic Melanoma

Pharmaceutics, 2019
While melanoma remains a challenge for oncologists, possibilities are being continuously explored to fight resistant metastatic melanoma more effectively. Eugenol is reported to inhibit survivin protein in breast cancer cells.
Harshita Mishra, Pawan Kumar Mishra, Zeenat Iqbal, Manu Jaggi, Alka Madaan, Kimi Bhuyan, Namita Gupta, Neha Gupta, Karnika Vats, Ritu Verma, Sushama Talegaonkar   +10 more
doaj   +1 more source

The therapeutic potential and molecular mechanism of Alpha-pinene, Gamma-terpinene, and P-cymene against melanoma cells

Heliyon
The purpose of this study is to investigate the potential anticarcinogenic effects of three phytochemicals, namely Alpha-pinene (AP), Gamma-terpinene (GT), and P-cymene (PC), on melanoma cells (A2058 cell line).
Funda Cimen Acikgul, Nizami Duran, Tuncer Kutlu, Emrah Ay, Erhan Tek, Suphi Bayraktar   +5 more
doaj   +1 more source

Hodgkin lymphoma treatment with ABVD in the US and the EU: neutropenia occurrence and impaired chemotherapy delivery [PDF]

, 2010
BACKGROUND: In newly diagnosed patients with Hodgkin lymphoma (HL) the effect of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD)-related neutropenia on chemotherapy delivery is poorly documented.
Lyman, Gary H., Lyman, Gary H, Szucs Thomas D, Culakova Eva, Szucs, Thomas D., Thomas D Szucs, Pettengell, Ruth, Szucs, Thomas D, Eva Culakova, Lyman, GH, Culakova, Eva, Ruth Pettengell, Matthias Schwenkglenks, Pettengell, R, Schwenkglenks, Matthias, Szucs, TD, Gary H Lyman, Pettengell Ruth, Culakova, E, Schwenkglenks Matthias, Lyman Gary H, Lyman, G H, Szucs, T D, Schwenkglenks, M   +23 more
core   +1 more source

Phase I clinical trial of the Src inhibitor dasatinib with dacarbazine in metastatic melanoma. [PDF]

, 2012
BackgroundSrc inhibitors sensitise melanoma cells to chemotherapy in preclinical models. The combination of dasatinib and dacarbazine was tested in a phase I trial in melanoma.MethodsPatients had ECOG performance status 0-2 and normal organ function ...
Weber, JS, Daud, AI, Algazi, AP, Urbas, P, Munster, PN, Hwang, J, Andrews, SC, McCalmont, T, DeConti, RC, Messina, JL, Sondak, VK   +10 more
core   +1 more source

Prospective study of the evolution of blood lymphoid immune parameters during dacarbazine chemotherapy in metastatic and locally advanced melanoma patients.

PLoS ONE, 2014
BackgroundThe importance of immune responses in the control of melanoma growth is well known. However, the implication of these antitumor immune responses in the efficacy of dacarbazine, a cytotoxic drug classically used in the treatment of melanoma ...
Grégoire Mignot, Alice Hervieu, Pierre Vabres, Sophie Dalac, Geraldine Jeudy, Blandine Bel, Lionel Apetoh, François Ghiringhelli   +7 more
doaj   +1 more source

Mesoporous‐Shell Monolayer Plasmonic Architecture Enables Quantitative and Decision‐Guided SERS

Advanced Science, EarlyView.
Mesoporous‐shell‐regulated molecular transport combined with monolayer hotspot determinism transforms surface‐enhanced Raman spectroscopy (SERS) from ultrasensitive detection into quantitative and decision‐guided molecular sensing. ABSTRACT Quantitative surface‐enhanced Raman spectroscopy (SERS) has long been impeded by stochastic hotspot formation ...
Guangyao Huang, Ying Wang, Yue Fang, Jingyuan Shao, Sensen Hao, Mancun Zhao, Yuan Yao, Junping Wang, Wei Zhou, Hongzhi Wang   +9 more
wiley   +1 more source

Phase III trial of dacarbazine versus dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: an Eastern Cooperative Oncology Group study.

, 1998
PURPOSE To investigate the response rate, time to treatment failure (TTF), overall survival, and toxicity in patients with metastatic melanoma treated with dacarbazine alone, dacarbazine plus interferon (IFN), dacarbazine plus tamoxifen (TMX), or ...
J M Kirkwood, A S Coates, C I Falkson, J Ibrahim, M B Atkins, R H Blum   +5 more
core   +1 more source

Selumetinib in combination with dacarbazine in patients with metastatic uveal melanoma: a phase III, multicentre, randomised trial (SUMIT) [PDF]

, 2018
Purpose: Uveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting.
Paul B. Chapman, Berking, Carola, Josep M. Piulats, Lauris Gastaud, Richard D. Carvajal, Pitulats, Josep M., Peter Barker, Gerald Linette, Elaine Kilgour, Sophie Piperno-Neumann, Pascal Wolter, Spratt, Shirley, Stephen Frank, Gary K. Schwartz, Bartosz Chmielowski, Paul Nathan, Chmielowski, Bartosz, Schwartz, Gary K., Rodrigues, Manuel J., Shirley Spratt, Kilgour, Elaine, Chapman, Paul B., Mariani, Gabriella, Schatchter, Jacob, Ellen Kapiteijn, Joshua, Anthony M., Nathan, Paul, Piperno-Neumann, Sophie, Ghiorghiu, Dana, Kapiteijn, Ellen, Zhongwu Lai, Anthony M. Joshua, Dana Ghiorghiu, Susan Lovick, Linette, Gerald, Carola Berking, Alexander N. Shoushtari, T.R. Jeffry Evans, Jacob Schachter, Lovick, Susan, Gabriella Mariani, Wolter, Pascal, Gastaud, Lauris, Shoushtari, Alexander N., Evans, T.R. Jeffry, Manuel J. Rodrigues, Cocquyt, Veronique, Veronique Cocquyt, Carvajal, Richard D., Lai, Zhongwu, Frank, Stephen, Clemett, Delyth, Barker, Peter, Delyth Clemett   +53 more
core   +1 more source