Results 11 to 20 of about 17,734 (168)

Post first-line dacarbazine or temozolomide in neuroendocrine carcinoma

Endocrine Connections, 2020
Objective: First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment.
Thomas Couronne, Paul Girot, Julien Hadoux, Thierry Lecomte, Alice Durand, Caroline Fine, Katia Vandevoorde, Catherine Lombard-Bohas, Thomas Walter   +8 more
doaj   +2 more sources

OUR EXPERIENCE WITH DACARBAZINE IN THE TREATMENT OF PATIENTS WITH INOPERABLE SKIN MELANOMA [PDF]

Journal of IMAB, 2016
Objective: The standard treatment for inoperable skin melanoma is chemotherapy. The aim of this study was to explore the efficacy and safety of therapy with dacarbazine in patients with advanced melanoma.
Deyan Davidov
doaj   +2 more sources

Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran

Electronic Physician, 2016
Objective: This study was carried out to investigate the ability of Propolis to ameliorate the adverse cytogenetic effects of Dacarbazine on bone marrow cells Methods: In this experimental in vivo study, 18 mice were used, divided into four groups ...
Lina Abdul-Fattah Kurdi, Fatimah Aliyan Aljeddani   +1 more
doaj   +2 more sources

Cost-effectiveness analysis of eribulin versus dacarbazine in patients with advanced liposarcoma

Scientific Reports
A subgroup analysis of a randomized study demonstrated that patients with advanced or metastatic liposarcoma treated with eribulin had longer overall survival and progression-free survival compared to those treated with dacarbazine, suggesting eribulin ...
Miaomiao Zhang, Jinlong Huang, Xiaochun Zheng, Ping Huang, Xiuli Yang   +4 more
doaj   +2 more sources

MiR-204-5p overexpression abrogates Dacarbazine-induced senescence in melanoma cells in vivo

Non-coding RNA Research
Cancer cell drug resistance hinders significantly therapeutic modalities in oncology. Dacarbazine is chemotherapeutic agent traditionally used for melanoma treatment although it's effectiveness insufficient.
Ekaterina Lapkina, Ivan Zinchenko, Viktoriya Kutcenko, Eugeniya Bondar, Andrey Kirichenko, Irina Yamskikh, Nadezhda Palkina, Tatiana Ruksha   +7 more
doaj   +2 more sources

Targeted Therapies Compared to Dacarbazine for Treatment of BRAFV600E Metastatic Melanoma: A Cost-Effectiveness Analysis [PDF]

Journal of Skin Cancer, 2015
Purpose. Two BRAFV600E targeted therapies, dabrafenib and vemurafenib, have received US approval for treatment of metastatic melanoma in BRAFV600E patients, a mutation that affects ~50% of patients.
Vanessa Shih, Renske M. ten Ham, Christine T. Bui, Dan N. Tran, Jie Ting, Leslie Wilson   +5 more
doaj   +2 more sources

Late Onset of Cardiac Metastasis of a Melanoma following Nivolumab Immunotherapy

Case Reports in Oncology, 2022
In this report, we present a case of cardiac metastasis of a malignant melanoma originating from the nasal cavity and presenting with cardiac tamponade detected during immunotherapy.
Kenta Nakamura, Hiroshi Koga, Yuko Takazawa, Toshikazu Omodaka, Yukiko Kiniwa, Ryuhei Okuyama   +5 more
doaj   +1 more source

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma [PDF]

, 2011
Background Ipilimumab monotherapy (at a dose of 3 mg per kilogram of body weight), as compared with glycoprotein 100, improved overall survival in a phase 3 study involving patients with previously treated metastatic melanoma.
Thomas, Luc, Richards, Jon, Davidson, Neville, Robert, Caroline, Harmankaya, Kaan, Hoos, Axel, Weber, Jeffrey, Gascon, Pere, Ibrahim, Ramy, Francis, Stephen, O’Day, Steven, Humphrey, Rachel, Miller, Wilson H., Wolchok, Jedd D., Baurain, Jean-François, Testori, Alessandro, Grob, Jean-Jacques, Chen, Tai-Tsang, Bondarenko, Igor, Maio, Michele, Lotem, Michal, Hauschild, Axel, Garbe, Claus, Lebbe, Celeste   +23 more
core   +2 more sources

The computational study of the tautomerization of Dacarbazine in a biological system: The DFT approach [PDF]

Journal of Particle Science and Technology, 2020
The aim of this study was to examine dacarbazine tautomerization with the density functional theory, where two tautomer structures have been indicated. The B3LYP/ 6-311G++ (d, p) , 6-311(d, p), and 6-311 quantum methods were considered to calculate the ...
Yasaman Najibzade, Enayatollah Sheikhhosseini, Mohammad Reza Akhgar, Sayed Ali Ahmadi   +3 more
doaj   +1 more source

Optimizing Dacarbazine Therapy: Design of a Laser-Triggered Delivery System Based on β-Cyclodextrin and Plasmonic Gold Nanoparticles

Pharmaceutics, 2023
Dacarbazine (DB) is an antineoplastic drug extensively used in cancer therapy. However, present limitations on its performance are related to its low solubility, instability, and non-specificity.
Sebastián Quintana-Contardo, Orlando Donoso-González, Erika Lang, Ariel R. Guerrero, Michael Noyong, Ulrich Simon, Marcelo J. Kogan, Nicolás Yutronic, Rodrigo Sierpe   +8 more
doaj   +1 more source