Results 21 to 30 of about 17,734 (168)

Molecular docking and physicochemical studies of 1,3-benzodioxole tagged Dacarbazine derivatives as an anticancer agent

Artificial Cells, Nanomedicine, and Biotechnology, 2023
Cancer, the biggest cause of death globally, remains a tough illness despite enormous advances in therapy. In the present study, 1,3-benzodioxole-tagged dacarbazine derivates were investigated as microtubule inhibitors in order to control cancer as ...
Sonaxi Kharb, Sangeeta Yadav, Anshul Singh, Anjana Sarkar, Ravi Tomar   +4 more
doaj   +1 more source

Synthesis, Spectroscopic, and Theoretical Study of Copper and Cobalt Complexes with Dacarbazine [PDF]

, 2021
Dacarbazine (DAC) 5-(3,3-dimethyl-1-triazenyl)imidazole-4-carboxamide is an imidazole-carboxamide derivative that is structurally related to purines.
Lewandowski, Wlodzimierz, Swislocka, Renata, Michał Sienkiewicz, Lewandowski, Włodzimierz, Renata Świsłocka, Ryszard Łaźny, Golonko, Aleksandra, Sienkiewicz, Michal, Matejczyk, Marzena, Grzegorz Świderski, Aleksandra Golonko, Lazny, Ryszard, Kalinowska, Monika, Marzena Matejczyk, Łaźny, Ryszard, Świderski, Grzegorz, Włodzimierz Lewandowski, Sienkiewicz, Michał, Świsłocka, Renata, Ali Osman Acar, Monika Kalinowska, Acar, Ali Osman   +21 more
core   +1 more source

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]

, 2014
BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Ferguson, J., Claudia Wellbrock, Erice, O., Margison, G.P., Goicoechea, I., Geoffrey P Margison, Margison, Geoffrey P, Wellbrock, C., Wellbrock, Claudia, Jennnifer Ferguson, Arozarena, Imanol, Goicoechea, Ibai, Imanol Arozarena, Ferguson, Jennnifer, Erice, Oihane, Oihane Erice, Ibai Goicoechea   +16 more
core   +1 more source

CLINICAL AND ECONOMIC EVALUATION OF ERIBULIN EFFECTIVENESS IN SOFT TISSUE SARCOMA: RESULTS OF META-ANALYSIS

Фармакоэкономика, 2017
Innovative drugs eribulin and trabectedin are effective in the treatment of soft tissue sarcomas (STS) – rare, but severe malignancies.Aim of the study.
P. V. Мazin, I. V. Sheshunov, N. K. Mazina, E. M. Markova   +3 more
doaj   +1 more source

Cold Atmospheric Plasma Is a Potent Tool to Improve Chemotherapy in Melanoma In Vitro and In Vivo

Biomolecules, 2020
Malignant melanoma is a devastating disease. Because of its aggressiveness, it also serves as a model tumor for investigating novel therapeutic avenues.
Mina Alimohammadi, Monireh Golpour, Farshad Sohbatzadeh, Seyedehniaz Hadavi, Sander Bekeschus, Haleh Akhavan Niaki, Reza Valadan, Alireza Rafiei   +7 more
doaj   +1 more source

Metastatic melanoma – a review of current and future drugs

Drugs in Context, 2012
Background: Melanoma is one of the most aggressive cancers, and it is estimated that 76,250 men and women will be diagnosed with melanoma of the skin in the USA in 2012.
Tiago Rodrigues Velho
doaj   +1 more source

pH dependence of dacarbazine adsorption on activated carbon: DFT study

, 2019
Density Functional Theory (DFT) methods supply important aspects of dacarbazine adsorption on a carbon surface, by providing atomistic details through molecular modeling.
G. Román, A. Juan, E. Noseda Grau, S. Simonetti, A. Díaz Compañy   +4 more
core   +2 more sources

Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients

OncoImmunology, 2018
We have recently described that DNA-damage inducing drug DTIC, administered before peptide (Melan-A and gp100)-vaccination, improves anti-tumor CD8+ Melan-A-specific T-cell functionality, enlarges the Melan-A+ TCR repertoire and impacts the overall ...
Belinda Palermo, Ornella Franzese, Cosmo Di Donna, Mariangela Panetta, Concetta Quintarelli, Isabella Sperduti, Novella Gualtieri, Maria Laura Foddai, Enrico Proietti, Virginia Ferraresi, Gennaro Ciliberto, Paola Nisticò   +11 more
doaj   +1 more source

Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells

Molecules, 2022
Nowadays, many individuals, whether healthy or diagnosed with disease, tend to expose themselves to various easily accessible natural products in hopes of benefiting their health and well-being. Mediterranean populations have traditionally used olive oil
Azra Kugić, Sanja Dabelić, Cvijeta Jakobušić Brala, Nina Dabelić, Monika Barbarić   +4 more
doaj   +1 more source

In Vitro Inhibition of Melanoma (B16f10) Viability and Colonization through Combining Metformin and Dacarbazine [PDF]

Middle East Journal of Cancer, 2020
Background: Dacarbazine is considered as a standard treatment for melanoma, but resistance to anticancer therapy is a major cause of cancer stem cells invasion.
Marjan Hajimoradi Javarsiani, Shagayegh Haghjooy Javanmard, Javad Sajedianfard   +2 more
doaj   +1 more source