Results 51 to 60 of about 3,595 (167)
Antimicrobial Agents and ChemotherapyA hub and spoke model for optimizing long-term treatment of chronic staphylococcal infections with dalbavancin based on therapeutic drug monitoring (TDM)-guided expert clinical pharmacological advice (ECPA) was implemented.
Piergiogio Cojutti +19 more
semanticscholar +1 more source
Antibiotics, 2022 Background: Our aim was to describe the clinical outcome and safety of the sequential treatment with off-label dalbavancin in patients with spondylodiscitis that is caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: We retrospectively
Maria Mazzitelli +7 more
doaj +1 more source
Small, Volume 22, Issue 16, 17 March 2026.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Efficacy and safety of dalbavancin in the treatment of Gram-positive bacterial infections
Journal of Global Antimicrobial Resistance, 2021 Objectives: In this meta-analysis, we assessed the clinical efficacy and safety of dalbavancin compared with commonly used anti-Gram-positive agents. Methods: PubMed, Embase and Cochrane Library databases were searched from inception up to 25 February ...
Yuhang Wang +4 more
doaj +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 2, February 2026.ABSTRACT Background and Aims One of the important complications of knee and hip replacement arthroplasty is prosthetic joint infection (PJI), which is usually accompanied by negative culture that leads to severe consequences compared to positive ones. This study aims to evaluate the arbitrary use or mistreatment of antibiotics for therapeutic purposes ...
Moein Zangiabadian +4 more
wiley +1 more source
Therapeutic Advances in Infectious DiseaseBackground: Treatment of invasive gram-positive infections in complex patient populations is challenging. Dalbavancin, approved for skin and soft tissue infections, offers advantages in this setting due to its long half-life and infrequent dosing ...
Hongkai Bao +5 more
doaj +1 more source
Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection
Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon +9 more
wiley +1 more source
In vitro activity of Tedizolid and Dalbavancin against MRSA strains is dependent on infection source
International Journal of Infectious Diseases, 2019 Objective: We tested the in vitro susceptibility to Tedizolid and Dalbavancin of Methicillin-resistant Staphylococcus aureus strains recovered from blood and wound cultures, and compared our results with studies conducted in the last four years.
Maya Azrad +4 more
doaj +1 more source
Vancomycin‐Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.This review consolidates recent advancements in VAN nanoformulations, critically evaluating their design principles, release mechanisms, and efficacy profiles against resistant Gram‐positive pathogens. While promising in vitro and in vivo results have been demonstrated, the clinicaltranslation of these technologies necessitates further rigorous ...
Nima Beheshtizadeh +5 more
wiley +1 more source