Results 101 to 110 of about 55,722 (248)
Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantation. [PDF]
EBioMedicine, 2023 Lucas-Ruiz F +13 more
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Activation of human eosinophils by exogenous danger signals
, 2004 Eosinophilic granulocytes are leukocytes that reside in the gastrointestinal and respiratory tracts. Their function in health is unknown. They are involved in variety of diseases with no clear common denominator: allergic disorders, parasitic and other ...
Svensson, Lena 1973-
core
Wild chimpanzees inform ignorant group members of danger
, 2012 The ability to recognize other individuals' mental states their knowledge and beliefs, for example is a fundamental part of human cognition and may be unique to our species.
Crockford, C. ; https://orcid.org/ +8 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals. [PDF]
J Neuroinflammation, 2021 Fischer S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Role of Mitochondria-Derived Danger Signals Released After Injury in Systemic Inflammation and Sepsis. [PDF]
Antioxid Redox Signal, 2021 Itagaki K +6 more
europepmc +1 more source
Cell death and immunity in cancer: from danger signals to mimicry of pathogen defence responses
, 2017 The immunogenicity of cancer cells is an emerging determinant of anti-cancer immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell-based vaccines, immune-checkpoint blockers, and adoptive T-cell transfer, investigators are ...
Garg, Abhishek, Agostinis, Patrizia
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source