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Hepatotoxicological Evaluation of Dantrolene Sodium [PDF]

Drug and Chemical Toxicology, 1984
The clinical use of dantrolene has been associated with hepatotoxicity, thus the toxicity of dantrolene in Swiss-Webster mice was characterized. Animals were treated orally (po) with single or multiple doses of up to 400 mg/kg of D without any increases in SGPT or alterations in hepato-cellular architecture.
Justin Durham, A. Jay Gandolfi, John B. Bentley   +2 more
openalex   +4 more sources

Successful management of malignant hyperthermia without dantrolene: A case report [PDF]

Journal of International Medical Research
Malignant hyperthermia during surgery represents a significant challenge for anesthesiologists due to its high mortality rate and the risk of long-term physiological damage.
Cailing Zhang, Huanbin Wang, Zhi Chen, Yuennong Zhang   +3 more
doaj   +2 more sources

Dantrolene [PDF]

Canadian Anaesthetists’ Society Journal, 1984
Beverley A. Britt
openalex   +4 more sources

Structure of Dantrolene

Analytical Sciences: X-ray Structure Analysis Online, 2004
The title compound, C14H10N4O5·CH4O, is a direct-acting skeletal relaxant. The crystal, obtained as a methanol solvate, belongs to space group P1 with the cell dimensions a=7.92(3), b=9.93(4) and c=10.57(3)A, α=87.7(2), β=85.2(2) and γ=72.2(2)°. The final R value is 0.066. The molecule takes a planar and fully extended structure.
Rumiko Tanaka, Toshio Akimoto, Masayuki Haramura, Akito Tanaka, Noriaki Hirayama   +4 more
openalex   +4 more sources

Impairment of Glucose Uptake Induced by Elevated Intracellular Ca²⁺ in Hippocampal Neurons of Malignant Hyperthermia-Susceptible Mice [PDF]

Cells
Malignant hyperthermia (MH) is a genetic disorder triggered by depolarizing muscle relaxants or halogenated inhalational anesthetics in genetically predisposed individuals who have a chronic elevated intracellular Ca2+ concentration ([Ca2+]i) in their ...
Arkady Uryash, Alfredo Mijares, Jose A. Adams, Jose R. Lopez   +3 more
doaj   +2 more sources

Reconstitution of Dantrolene [PDF]

Anesthesiology, 1988
A. W. FOX, Helen Campbell
openalex   +3 more sources

Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca²⁺]—Neuroprotective Effect of Reducing Intracellular [Ca²⁺]: In Vivo and In Vitro Studies [PDF]

Cells
Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear.
Arkady Uryash, Alfredo Mijares, Carlos E. Lopez, Jose A. Adams, Paul D. Allen, Jose R. Lopez   +5 more
doaj   +2 more sources

Loose-patch clamp analysis applied to voltage-gated ionic currents following pharmacological ryanodine receptor modulation in murine hippocampal cornu ammonis-1 pyramidal neurons [PDF]

Frontiers in Physiology
IntroductionThe loose-patch clamp technique was first developed and used in native amphibian skeletal muscle (SkM), offering useful features complementing conventional sharp micro-electrode, gap, or conventional patch voltage clamping.
Federico Bertagna, Federico Bertagna, Shiraz Ahmad, Rebecca Lewis, Rebecca Lewis, S. Ravi P. Silva, S. Ravi P. Silva, Johnjoe McFadden, Johnjoe McFadden, Christopher L.-H. Huang, Christopher L.-H. Huang, Christopher L.-H. Huang, Hugh R. Matthews, Kamalan Jeevaratnam, Kamalan Jeevaratnam   +14 more
doaj   +2 more sources

DANTROLENE AND THE TREATMENT OF MALIGNANT HYPERTHERMIA

British Journal of Anaesthesia, 1980
G. M. Hall
openalex   +4 more sources

Pharmacokinetics of Dantrolene in the Plasma Exchange Treatment of Malignant Hyperthermia in a 14-Year-Old Chinese Boy: A Case Report and Literature Review

Frontiers in Medicine, 2022
Malignant hyperthermia (MH) is a rare life-threatening response that is triggered by exposure to specific anesthetics commonly used during surgical interventions. Dantrolene is a well-known drug used as the first-line therapy for MH.
Xiaoxiao Li, Xiaoxiao Li, Chao Li, Yang Zhou, Yang Zhou, Zhengqian Li, Zhengqian Li, Xin Xiong, Chuhui Wang, Chuhui Wang, Congya Zhou, Congya Zhou, Bin Han, Li Yang, Xiangyang Guo, Xiangyang Guo   +15 more
doaj   +1 more source