Results 1 to 10 of about 9,798 (259)
PLoS ONE, 2015 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from ...
Sari U M Vanninen +2 more
exaly +3 more sources
BMC Anesthesiology, 2022 Background Intravenous dantrolene is often prescribed for hypermetabolic syndromes other than the approved indication of malignant hyperthermia (MH). To clarify the extent of and indications for dantrolene use in conditions other than MH, we sought to ...
Stanley N. Caroff +7 more
doaj +2 more sources
A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome
JCI Insight, 2021 BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration.
Damien Abreu +16 more
doaj +2 more sources
Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
doaj +2 more sources
Scientific Reports, 2021 Diabetics have a higher risk of developing cerebral vasospasms (CVSP) after subarachnoid hemorrhagic stroke than non-diabetics. Serotonin (5-HT) is one of the key vasoconstrictors released in the hemorrhagic blood and an important contributor to the ...
Marie Román +3 more
doaj +2 more sources
Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
Frontiers in Pharmacology, 2021 Background and Purpose: Doxorubicin (DOX) is a risk factor for arm lymphedema in breast cancer patients. We reported that DOX opens ryanodine receptors (RYRs) to enact “calcium leak,” which disrupts the rhythmic contractions of lymph vessels (LVs) to ...
Serena Van +8 more
doaj +2 more sources
Hepatotoxicological Evaluation of Dantrolene Sodium [PDF]
Drug and Chemical Toxicology, 1984 The clinical use of dantrolene has been associated with hepatotoxicity, thus the toxicity of dantrolene in Swiss-Webster mice was characterized. Animals were treated orally (po) with single or multiple doses of up to 400 mg/kg of D without any increases in SGPT or alterations in hepato-cellular architecture.
Justin Durham +2 more
openalex +4 more sources
Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model. [PDF]
PLoS ONE, 2018 The ryanodine receptor antagonist dantrolene inhibits calcium release from the sarcoplasmic reticulum and reduces cardiac ischaemia-reperfusion injury (IRI) in global warm ischaemia models however the cardioprotective potential of dantrolene under ...
Jeanette E Villanueva +8 more
doaj +2 more sources
Successful management of malignant hyperthermia without dantrolene: A case report [PDF]
Journal of International Medical ResearchMalignant hyperthermia during surgery represents a significant challenge for anesthesiologists due to its high mortality rate and the risk of long-term physiological damage.
Cailing Zhang +3 more
doaj +2 more sources
Malignant hyperthermia and dantrolene sodium [PDF]
Korean Journal of Anesthesiology, 2019 in Korea. The patient was treated with conventional methods including dantrolene, but the patient’s condition became aggravated, requiring the application of an extracorporeal membrane oxygenator (ECMO) to support cardiopulmonary resuscitation [1 ...
Ha Jung Kim +4 more
openaire +5 more sources