Results 11 to 20 of about 14,850 (297)

Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress

Biochemistry and Biophysics Reports, 2020
Introduction: Our previous studies demonstrated that dantrolene, a ryanodine receptor stabilizer, prevents endoplasmic reticulum (ER) stress in the heart.
Masaki Tamitani, Takeshi Yamamoto, Naoki Yamamoto, Koichi Fujisawa, Shinji Tanaka, Yoshihide Nakamura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Taro Takami, Shigeki Kobayashi, Isao Sakaida, Masafumi Yano   +12 more
doaj   +2 more sources

Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models

PLoS ONE, 2015
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from ...
Sari U M Vanninen, Kimmo K Kontula, Katriina Aalto-Setälä   +2 more
exaly   +2 more sources

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis [PDF]

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 2056-2067, October 2025.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +2 more sources

Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure modelKey Findings

Heart Rhythm O2, 2020
Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and ...
Colleen Nofi, DO, Kuo Zhang, MD, PhD, Yi-Da Tang, MD, PhD, Ying Li, BS, Allan Migirov, MBS, Kaie Ojamaa, PhD, A. Martin Gerdes, PhD, Youhua Zhang, MD, PhD   +7 more
doaj   +2 more sources

Successful management of malignant hyperthermia without dantrolene: A case report [PDF]

Journal of International Medical Research
Malignant hyperthermia during surgery represents a significant challenge for anesthesiologists due to its high mortality rate and the risk of long-term physiological damage.
Cailing Zhang, Huanbin Wang, Zhi Chen, Yuennong Zhang   +3 more
doaj   +2 more sources

Dantrolene-Responsive Muscle Stiffness in a Patient With a Normal Neurologic Exam and EMG: A Case Report [PDF]

Case Reports in Neurological Medicine
Muscle stiffness or rigidity is a common problem yet is addressed in few studies. Patients with muscle rigidity/spasticity due to injury of upper motor neurons or genetic muscle diseases are sometimes treated with dantrolene.
Adam S. Deardorff, Matthew J. Burford, Mark M. Rich   +2 more
doaj   +2 more sources

Malignant hyperthermia crisis during scoliosis surgery in a pediatric cerebral palsy patient: a case of early recognition and successful intervention [PDF]

Frontiers in Pediatrics
BackgroundMalignant hyperthermia (MH) is a rare but life-threatening complication of general anesthesia, characterized by a hypermetabolic response that can lead to severe complications if not managed promptly. Patients with neuromuscular disorders, such
Saleh M. Kardm, Abdulmonem Alsiddiky, Asim J. Alamri, Ravi Shankar Reddy   +3 more
doaj   +2 more sources

Availability of dantrolene for the management of malignant hyperthermia crises: European Malignant Hyperthermia Group guidelines

British Journal of Anaesthesia, 2020
Philip M Hopkins
exaly   +2 more sources

Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate

BMJ Case Reports, 2018
There has been a resurgence in the use of 2,4-dinitrophenol, C6H4N2O5 (DNP) recently as an illegal weight loss drug. We present a case of a healthy 25-year-old girl who took two tablets of DNP, purchased from an overseas online retailer.
Jason Van Schoor, Esha Khanderia, Andrew Thorniley   +2 more
openalex   +3 more sources

The Effectiveness of a Mobile National Remote Emergency System for Malignant Hyperthermia in China: Retrospective Pre-Post Implementation Study

Journal of Medical Internet Research
BackgroundMalignant hyperthermia (MH) seriously threatens perioperative safety. Historically, limited awareness of MH among anesthesiologists and the unavailability of dantrolene have caused a high mortality rate of MH events in China.
Lingcan Tan, Hong Yu, Yunxia Zuo, Bin Liu, Tao Zhu, Xiaoqian Deng   +5 more
doaj   +2 more sources