Results 21 to 30 of about 14,850 (297)
Effects of Dantrolene on Steps of Excitation-Contraction Coupling in Mammalian Skeletal Muscle Fibers [PDF]
, 2001 Péter Szentesi +7 more
openalex +4 more sources
Current clinical application of dantrolene sodium
Anesthesia and Pain Medicine, 2023 Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
H. Yang +5 more
semanticscholar +1 more source
Molecular Aspects Implicated in Dantrolene Selectivity with Respect to Ryanodine Receptor Isoforms
International Journal of Molecular Sciences, 2023 Dantrolene is an intra-cellularly acting skeletal muscle relaxant used for the treatment of the rare genetic disorder, malignant hyperthermia (MH).
J. Gaburjáková, M. Gaburjáková
semanticscholar +1 more source
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6
The Journal of General Physiology, 2023 Dantrolene, an inhibitor of the cardiac calcium release channel (RyR2), is a lead compound for stabilizing overactive RyR2 in heart failure. We find that dantrolene inhibition requires RyR2 association with FKBP12.6, which in turn depends on RyR2 ...
K. Walweel +3 more
semanticscholar +1 more source
Frontiers in Medicine, 2022 Malignant hyperthermia (MH) is a rare life-threatening response that is triggered by exposure to specific anesthetics commonly used during surgical interventions. Dantrolene is a well-known drug used as the first-line therapy for MH.
Xiaoxiao Li +15 more
doaj +1 more source
Anesthesia and Analgesia, 2022 BACKGROUND: Patients susceptible to malignant hyperthermia (MH) may experience disabling manifestations of an unspecified myopathy outside the context of anesthesia, including myalgia, fatigue, or episodic rhabdomyolysis.
C. A. Ibarra Moreno +5 more
semanticscholar +1 more source
Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model. [PDF]
PLoS ONE, 2018 The ryanodine receptor antagonist dantrolene inhibits calcium release from the sarcoplasmic reticulum and reduces cardiac ischaemia-reperfusion injury (IRI) in global warm ischaemia models however the cardioprotective potential of dantrolene under ...
Jeanette E Villanueva +8 more
doaj +1 more source
Malignant hyperthermia when dantrolene is not readily available
BMC Anesthesiology, 2021 Background Malignant hyperthermia is a rare but life-threatening pharmacogenetic muscle disorder characterized by abnormal hypermetabolic reactions and commonly triggered in susceptible individuals by volatile anesthetics or succinylcholine, or both ...
Xiaodan Gong
semanticscholar +1 more source