Results 21 to 30 of about 9,798 (259)

Molecular Aspects Implicated in Dantrolene Selectivity with Respect to Ryanodine Receptor Isoforms

International Journal of Molecular Sciences, 2023
Dantrolene is an intra-cellularly acting skeletal muscle relaxant used for the treatment of the rare genetic disorder, malignant hyperthermia (MH).
J. Gaburjáková, M. Gaburjáková
semanticscholar   +1 more source

Current clinical application of dantrolene sodium

Anesthesia and Pain Medicine, 2023
Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
H. Yang, J. Choi, J. In, Tae-yun Sung, Yong Beom Kim, Shofina Sultana   +5 more
semanticscholar   +1 more source

DANTROLENE AND THE TREATMENT OF MALIGNANT HYPERTHERMIA

British Journal of Anaesthesia, 1980
G. M. Hall
openalex   +4 more sources

Rapid Dantrolene Administration with Body Temperature Monitoring Is Associated with Decreased Mortality in Japanese Malignant Hyperthermia Events

BioMed Research International, 2023
Purpose Malignant hyperthermia (MH) is a rare genetic disorder but one of the most severe complications of general anesthesia. The mortality rate of MH has dropped from 70% in the 1960s to 15% because of dantrolene, the only currently accepted specific ...
Yukari Toyota, T. Kondo, D. Shorin, Ayako Sumii, Kenshiro Kido, Tomoyuki Watanabe, Sachiko Otsuki, Rieko Kanzaki, H. Miyoshi, Toshimichi Yasuda, Yousuke T Horikawa, K. Mukaida, Y. Tsutsumi   +12 more
semanticscholar   +1 more source

Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6

The Journal of General Physiology, 2023
Dantrolene, an inhibitor of the cardiac calcium release channel (RyR2), is a lead compound for stabilizing overactive RyR2 in heart failure. We find that dantrolene inhibition requires RyR2 association with FKBP12.6, which in turn depends on RyR2 ...
K. Walweel, N. Beard, D. V. van Helden, D. Laver   +3 more
semanticscholar   +1 more source

Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene

Green Chemistry, 2018
Evelina Colacino, Andrea Porcheddu, Ivan Halasz   +2 more
exaly   +2 more sources

Pharmacokinetics of Dantrolene in the Plasma Exchange Treatment of Malignant Hyperthermia in a 14-Year-Old Chinese Boy: A Case Report and Literature Review

Frontiers in Medicine, 2022
Malignant hyperthermia (MH) is a rare life-threatening response that is triggered by exposure to specific anesthetics commonly used during surgical interventions. Dantrolene is a well-known drug used as the first-line therapy for MH.
Xiaoxiao Li, Xiaoxiao Li, Chao Li, Yang Zhou, Yang Zhou, Zhengqian Li, Zhengqian Li, Xin Xiong, Chuhui Wang, Chuhui Wang, Congya Zhou, Congya Zhou, Bin Han, Li Yang, Xiangyang Guo, Xiangyang Guo   +15 more
doaj   +1 more source

Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia–Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability

Anesthesia and Analgesia, 2022
BACKGROUND: Patients susceptible to malignant hyperthermia (MH) may experience disabling manifestations of an unspecified myopathy outside the context of anesthesia, including myalgia, fatigue, or episodic rhabdomyolysis.
C. A. Ibarra Moreno, N. Kraeva, E. Zvaritch, H. Jungbluth, N. Voermans, S. Riazi   +5 more
semanticscholar   +1 more source

The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia

Anaesthesia and Intensive Care, 2022
Dantrolene is currently the only drug known to specifically treat malignant hyperthermia (MH) crises. Although dantrolene attenuates Ca2+ disorders by acting mainly on the ryanodine receptor type 1 (RYR1), some patients who manifest MH without RYR1 ...
Yuko Noda, K. Mukaida, H. Miyoshi, R. Nakamura, Toshimichi Yasuda, N. Saeki, I. Nishino, Y. Tsutsumi   +7 more
semanticscholar   +1 more source

Electromagnetic fields modulate neuronal membrane ionic currents through altered cellular calcium homeostasis. [PDF]

Ann N Y Acad Sci
Electromagnetic fields (50 Hz, 1 mT) affect hippocampal CA1 neuron excitability by reducing membrane currents. These effects, blocked by agents targeting calcium signaling pathways, suggest EMFs influence neuronal function via disruption of Ca2⁺ homeostasis and voltage‐gated channel regulation. Abstract The biological effects of electromagnetic fields (
Bertagna F, Ahmad S, Lewis R, Silva SRP, McFadden J, Huang CL, Matthews HR, Jeevaratnam K.   +7 more
europepmc   +2 more sources