Results 21 to 30 of about 6,189 (214)
Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation
Frontiers in Pharmacology, 2021 Background and Purpose: Doxorubicin (DOX) is a risk factor for arm lymphedema in breast cancer patients. We reported that DOX opens ryanodine receptors (RYRs) to enact “calcium leak,” which disrupts the rhythmic contractions of lymph vessels (LVs) to ...
Serena Van +8 more
doaj +1 more source
Discovery and Treatment of Action Potential-Independent Myotonia in Hyperkalemic Periodic Paralysis. [PDF]
Ann Clin Transl NeurolABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Dupont C +4 more
europepmc +2 more sources
Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons
Neural Regeneration Research, 2015 Therapeutic hypothermia is the most promising non-pharmacological neuroprotective strategy against ischemic injury. However, shivering is the most common adverse reaction. Many studies have shown that dantrolene is neuroprotective in in vitro and in vivo
Sui-yi Xu +6 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2018 Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses anti-sense oligo-nucleotides (AONs) to force specific exon exclusion during mRNA processing to
Derek W. Wang +8 more
doaj +1 more source
Malignant hyperthermia in a regional facility: A case study
Journal of Perioperative Nursing, 2020 Malignant hyperthermia (MH) is a rare hypermetabolic state that may be triggered by both anaesthesia and non-anaesthesia triggers. The main anaesthesia triggers for MH are the depolarising muscle relaxant suxamethonium and volatile anaesthetic gases. MH
Catherine Kleidon
doaj +1 more source
Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina [PDF]
Arquivos de Neuro-Psiquiatria, 1998 A síndrome neuroléptica maligna (SNM) consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de ...
RICARDO A. HANEL +3 more
doaj +1 more source
Malignant hyperthermia in children [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 INTRODUCTION Malignant hyperthermia is a rare disease which is mainly an inherited autosomal dominant trait. It is characteristic for muscle rigidity, metabolism or respiratory acidosis, high values of serum creatine kinase.
Igrutinović Zoran +4 more
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Perioperative management of malignant hyperthermia during general anesthesia: A report of two cases
Clinical Case Reports, 2022 Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality.
Xiaowei Chi +5 more
doaj +1 more source
Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy
Case Reports in Anesthesiology, 2020 Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management ...
Warangkana Lapisatepun +1 more
doaj +1 more source
Memory and Learning Deficits Are Associated With Ca2+ Dyshomeostasis in Normal Aging
Frontiers in Aging Neuroscience, 2020 Neuronal intracellular Ca2+ homeostasis is critical to the normal physiological functions of neurons and neuronal Ca2+ dyshomeostasis has been associated with the age-related decline of cognitive functions.
Arkady Uryash +4 more
doaj +1 more source