Results 31 to 40 of about 9,798 (259)
Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress
Biochemistry and Biophysics Reports, 2020 Introduction: Our previous studies demonstrated that dantrolene, a ryanodine receptor stabilizer, prevents endoplasmic reticulum (ER) stress in the heart.
Masaki Tamitani +12 more
doaj +1 more source
Malignant hyperthermia when dantrolene is not readily available
BMC Anesthesiology, 2021 Background Malignant hyperthermia is a rare but life-threatening pharmacogenetic muscle disorder characterized by abnormal hypermetabolic reactions and commonly triggered in susceptible individuals by volatile anesthetics or succinylcholine, or both ...
Xiaodan Gong
semanticscholar +1 more source
Frontiers in Physiology, 2021 Ryanodine receptors (RyRs), the intracellular Ca2+ release channels, are expressed in T lymphocytes and other types of immune cells. Modulation of RyRs has been shown to affect T cell functions in vitro and immune responses in vivo.
Natalia C. Osipchuk +3 more
doaj +1 more source
The effect of long-term oral dantrolene on the neuromuscular action of rocuronium: a case report [PDF]
Korean Journal of Anesthesiology, 2014 Oral dantrolene causes a dose-dependent depression of skeletal muscle contractility. A 52-year-old man treated with oral dantrolene for spasticity after spinal cord injury was scheduled to undergo irrigation and drainage of a thigh abscess under general ...
Jinwoo Jeon +4 more
doaj +1 more source
Heart Rhythm O2, 2020 Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and ...
Colleen Nofi, DO +7 more
doaj +1 more source
Hyperthermia and neurological catastrophe: An interesting case report
Journal of Family Medicine and Primary Care, 2022 Fever is a common symptom encountered in clinical practice. Hyperthermia, though infrequently encountered, can be genetical (malignant hyperthermia) or acquired when the body temperature rises beyond a certain set point that is controlled by the ...
Khyati Thapliyal +2 more
doaj +1 more source
Dantrolene : From Malignant Hyperthermia to Alzheimer's Disease.
CNS and Neurological Disorders - Drug Targets, 2020 Dantrolene, a ryanodine receptor antagonist, is primarily known as the only clinically acceptable and effective treatment for malignant hyperthermia (MH). Inhibition of ryanodine receptor (RyR) by dantrolene decrease the abnormal calcium release from the
Yun Shi, Yong Wang, Huafeng Wei
semanticscholar +1 more source
Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons
Neural Regeneration Research, 2015 Therapeutic hypothermia is the most promising non-pharmacological neuroprotective strategy against ischemic injury. However, shivering is the most common adverse reaction. Many studies have shown that dantrolene is neuroprotective in in vitro and in vivo
Sui-yi Xu +6 more
doaj +1 more source
A case of malignant hyperthermia during anesthesia induction with sevoflurane -A case report- [PDF]
Korean Journal of Anesthesiology, 2010 We experienced a case of malignant hyperthermia (MH) in 6-year-old boy during anesthesia induction for strabismus surgery. It has been generally reported that sevoflurane can induce the delayed onset of MH in the absence of succinylcholine.
Yoon Sook Lee +6 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2018 Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses anti-sense oligo-nucleotides (AONs) to force specific exon exclusion during mRNA processing to
Derek W. Wang +8 more
doaj +1 more source