Results 51 to 60 of about 9,798 (259)

Combination Therapy of Allopurinol and Dantrolene and Its Role In The Prevention of Experimental Ischemia Reperfusion Injury Of The Small Intestine

Journal of Investigative Surgery, 2021
Background The effect of different drugs on ischemia and reperfusion (I/R; induced oxygen free radical damage) was examined in small bowel tissue because the intestine is extremely sensitive to this pathology. Different drugs (allopurinol and dantrolene)
Beatriz Prieto-Moure, Dolores Cejalvo-Lapeña, Mariola Belda-Antolí, Carolina Padrón-Sanz, José Miguel Lloris-Cejalvo, José Miguel Lloris-Carsí   +5 more
doaj   +1 more source

Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus.

Turkish Neurosurgery, 2020
AIM Status epilepticus (SE) may lead to cognitive dysfunction and neuronal loss in hippocampus. The aim of this study was to evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in ...
I. D. Gursoy, S. Barun, R. Erdem, U. Keskin, M. Kiziltas, P. Atilla, S. Muftuoglu, D. Yuce, F. Narin, M. Ertunç, Y. Sara, H. Canpınar   +11 more
semanticscholar   +1 more source

A Case of Fatal Malignant Hyperthermia During Pes Equinovarus Surgery in a Child

Journal of Pediatric Emergency and Intensive Care Medicine, 2018
Malignant hyperthermia (MH) is a genetic syndrome characterized by hyperthermia, tachycardia, acidosis, and muscle rigidity, often triggered by depolarizing muscle relaxants such as volatile anesthetics and/or succinylcholine.
Ümüt Altuğ, Fulya Kamit Can, Ayşe Berna Anıl, Fatih Durak, Meltem Çakmak, Gökçen Özçifçi   +5 more
doaj   +1 more source

Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats

International Journal of Endocrinology, 2018
Diabetics have a higher risk of developing cerebral vasospasms (CVSP) than nondiabetics. The addition of the ryanodine receptor (RyR) blocker dantrolene to standard therapies reduces vasospasms in nondiabetics.
Maria J. Crespo, Marie Roman, Jonathan Matias, Myrna Morales, Hector Torres, Jose Quidgley   +5 more
doaj   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina [PDF]

Arquivos de Neuro-Psiquiatria, 1998
A síndrome neuroléptica maligna (SNM) consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de ...
RICARDO A. HANEL, MARCOS C. SANDMANN, MARTINA KRANICH, PAULO R. M. DE BITTENCOURT   +3 more
doaj   +1 more source

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

Advanced Intelligent Systems, EarlyView.
The integration of sensing elements in bioengineered actuators is key to obtain real‐time information about their performance and further control/automation. By coupling flexible organic field‐effect transistor to a skeletal muscle actuator we demonstrate the feasibility to record in real‐time its contractile behavior when stimulated by electrical ...
Stefano Lai, Judith Fuentes, Maria Guix, Giulia Casula, Piero Cosseddu, Samuel Sánchez   +5 more
wiley   +1 more source

Clinical Features of Suspected Malignant Hyperthermia in China from 2015 to 2020: A Retrospective Study from China Malignant Hyperthermia Emergency Assistance Group

Journal of Multidisciplinary Healthcare, 2022
Lingcan Tan,1,* Yi Teng,1,* Hong Yu,1 Chunyuan Liu,2 Kun Xiao,3 Jin Yin,4 Yunxia Zuo,1 Tao Zhu,1 Xiaoqian Deng1 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Department of ...
Tan L, Teng Y, Yu H, Liu C, Xiao K, Yin J, Zuo Y, Zhu T, Deng X   +8 more
doaj  

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Nitrogen‐Centered Organic Persistent Radicals Catalyze Redox‐Neutral C─C Bond Forming Reactions

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
Kuhn verdazyls, discovered over 60 years ago, are shown as effective catalysts for the first time. Their tunable redox properties enable organocatalytic redox‐neutral C─H arylation and C─H trifluoromethylation reactions without light activation.
Shrouq Mujahed, Jaysan Janabel, Kundan Shaw, Roberta Cagliani, Tynchtyk Amatov   +4 more
wiley   +2 more sources