Electropermeabilization of inner and outer cell membranes with microsecond pulsed electric field. Quantitative study with calcium ions [PDF]
, 2017 Microsecond pulsed electric fields (mu sPEF) permeabilize the plasma membrane (PM) and are widely used in research, medicine and biotechnology. For internal membranes permeabilization, nanosecond pulsed electric fields (nsPEF) are applied but this ...
Andrã©, Franck M. +4 more
core +2 more sources
Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment
EMBO Molecular MedicineDarier disease (DD) is a rare severe acantholytic skin disease caused by mutations in the ATP2A2 gene that encodes for the sarco/endoplasmic reticulum calcium ATPase isoform 2 (SERCA2).
Matthew Hunt +16 more
semanticscholar +1 more source
Ryanodine receptors: physiological function and deregulation in Alzheimer disease [PDF]
, 2014 BackgroundHealth-care professionals have a responsibility to be attentive to patients’ adherence behavior but it could be difficult to identify poor adherence in the context of clinical practice.
Axelsson, Malin +3 more
core +2 more sources
Approaches To Optimizing Dantrolene Neuroprotection For The Treatment Of Alzheimer's Disease.
Current Alzheimer Research, 2020 Alzheimer's Disease (AD), a neurodegenerative disorder with high incidence and mortality, is leading its way to the top of the list of the deadliest diseases [1], without an effective disease-modifying drug.
Matan Ben Abou, Liang Sun, Huafeng Wei
semanticscholar +1 more source
Biomolecules & BiomedicineDantrolene is the definitive treatment for malignant hyperthermia (MH), a rare and life-threatening disorder. This retrospective study aimed to achieve two objectives: (1) to characterize the indications and frequency of dantrolene administration in ...
David Cho +5 more
doaj +1 more source
Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina [PDF]
Arquivos de Neuro-Psiquiatria, 1998 A síndrome neuroléptica maligna (SNM) consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de ...
RICARDO A. HANEL +3 more
doaj +1 more source
Delayed-Onset Malignant Hyperthermia in Association with Rocuronium Use [PDF]
, 2012 Purpose Two cases of malignant hyperthermia suspected to be related to the use of a nondepolarizing neuromuscular blocker are reported. Summary A pharmacogenetic disorder that may occur in as many as 1 in 3000 anesthesia procedures, malignant ...
Beggs, Ashton E. +2 more
core +2 more sources
Progesterone analogue protects stressed photoreceptors via bFGF-mediated calcium influx. [PDF]
, 2016 Retinitis pigmentosa (RP) is a degenerative retinal disease leading to photoreceptor cell loss. In 2011, our group identified the synthetic progesterone ‘Norgestrel’ as a potential treatment for RP.
Byrne, Ashleigh M. +5 more
core +1 more source
Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats
Heart Rhythm O2, 2020 Background: Bidirectional ventricular tachycardia (BD-VT) is an intriguing arrhythmia, characterized by a beat-to-beat alternation of the QRS polarity on electrocardiogram. Currently there is no simple BD-VT animal model.
Chenyu Zhang, BS, Youhua Zhang, MD, PhD
doaj +1 more source
Malignant hyperthermia in children [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 INTRODUCTION Malignant hyperthermia is a rare disease which is mainly an inherited autosomal dominant trait. It is characteristic for muscle rigidity, metabolism or respiratory acidosis, high values of serum creatine kinase.
Igrutinović Zoran +4 more
doaj +1 more source