Results 81 to 90 of about 9,798 (259)
Clinical Practice and Cases in Emergency Medicine, 2019 Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication resulting from neuroleptic drug therapy. Presentation of NMS can vary, and diagnosis relies primarily upon medical history and symptomatology. Due to the potential delay in
V. Ngo +6 more
semanticscholar +1 more source
Pain Practice, Volume 25, Issue 7, September 2025.ABSTRACT Introduction Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher ...
Wouter K. M. van Os +6 more
wiley +1 more source
Pharmacology Research & Perspectives, 2021 Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the
Christopher Rowbottom +6 more
doaj +1 more source
Dantrolene for the treatment of MDMA toxicity [PDF]
CJEM, 2010 ABSTRACTMDMA (3,4-methylenedioxymethamphetamine), popularly known as “Ecstasy,” was first introduced and patented by Merck & Co., Inc., in 1914 as an appetite suppressant. Currently, its primary role is as an illegal stimulant used to produce a euphoric effect during parties.
Brian Grunau +2 more
openaire +3 more sources
CellsMalignant hyperthermia (MH) is a genetic disorder triggered by depolarizing muscle relaxants or halogenated inhalational anesthetics in genetically predisposed individuals who have a chronic elevated intracellular Ca2+ concentration ([Ca2+]i) in their ...
Arkady Uryash +3 more
doaj +1 more source
Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1493-1502, August 2025.This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin +9 more
wiley +1 more source
Anesthesiology, 2018 What We Already Know about This TopicPrompt availability of dantrolene is important for treating malignant hyperthermia and has resulted in lowered mortality ratesMaintaining a malignant hyperthermia cart and full treatment dose of dantrolene is ...
P. Ho +4 more
semanticscholar +1 more source
Malignant hyperthermia: current approaches to prevention and treatment
Acta Biomedica Scientifica, 2017 One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic disease phenotype manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthesia with the use of inhaled
E. S. Kim +2 more
doaj +1 more source
Small, Volume 21, Issue 29, July 24, 2025.This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai +5 more
wiley +1 more source