Results 81 to 90 of about 9,385 (245)

Malignant hyperthermia: current approaches to prevention and treatment

open access: yesActa Biomedica Scientifica, 2017
One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic disease phenotype manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthesia with the use of inhaled
E. S. Kim   +2 more
doaj   +1 more source

Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene

open access: yes, 2018
The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as nitrofurantoin (Furantin©), dantrolene (Dantrium©) and their structurally related derivatives is ...
E. Colacino   +6 more
semanticscholar   +1 more source

Mutism and rigidity due to antipsychotic‐induced catatonia improved by hemodialysis: A case report

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 4, Issue 1, March 2025.
We present a case of antipsychotic‐induced catatonia (AIC) due to intramuscular injection of haloperidol that was promptly improved by hemodialysis. This report suggests the potential role of hemodialysis in improving AIC. Abstract Background Catatonia is a psychomotor syndrome linked to various medical conditions.
Rintaro Fujii   +4 more
wiley   +1 more source

Management of serotonin syndrome (toxicity)

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 3, Page 654-661, March 2025.
Serotonin syndrome (toxicity), resulting from an excessive accumulation of serotonin in the central nervous system, it can occur due to various factors such as the initiation of medication, overdose or drug interactions. Diagnosing serotonin toxicity presents challenges as there are no definitive criteria.
Angela L. Chiew, Geoffrey K. Isbister
wiley   +1 more source

Recrudescência fatal de hipertermia maligna em lactente com síndrome de Moebius. Relato de caso

open access: yesRevista Brasileira de Anestesiologia, 2013
JUSTIFICATIVA E OBJETIVOS: A hipertermia maligna (HM) é uma desordem farmacogenética da musculatura esquelética, caracterizada por estado hipermetabólico após anestesia com succinilcolina e/ou agentes anestésicos voláteis.
Cláudia Regina Fernandes   +4 more
doaj   +1 more source

Cost-benefit Analysis of Maintaining a Fully Stocked Malignant Hyperthermia Cart versus an Initial Dantrolene Treatment Dose for Maternity Units

open access: yesAnesthesiology, 2018
What We Already Know about This TopicPrompt availability of dantrolene is important for treating malignant hyperthermia and has resulted in lowered mortality ratesMaintaining a malignant hyperthermia cart and full treatment dose of dantrolene is ...
P. Ho   +4 more
semanticscholar   +1 more source

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

open access: yes
The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah   +2 more
wiley   +1 more source

Biological Function and Mechanism of NAT10 in Cancer

open access: yesCancer Innovation, Volume 4, Issue 1, February 2025.
N‐acetyltransferase 10 (NAT10) is an acetyltransferase that mediates the acetylation of proteins and RNA. NAT10 positively affects the proliferation, metastasis, invasion, and drug resistance of various cancers through the regulation of cancer‐related proteins and genes.
Yufeng Han   +6 more
wiley   +1 more source

Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.

open access: yesHuman Molecular Genetics, 2016
Neuronopathic Gaucher disease (nGD) manifests as severe neurological symptoms in patients with no effective treatment available. Ryanodine receptors (Ryrs) are a family of calcium release channels on intracellular stores.
B. Liou   +12 more
semanticscholar   +1 more source

Excitation–contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.
Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane   +9 more
wiley   +1 more source

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