Malignant hyperthermia and dantrolene sodium [PDF]
Korean Journal of Anesthesiology, 2019 Ha Jung Kim +4 more
doaj +7 more sources
Current clinical application of dantrolene sodium [PDF]
Anesthesia and Pain Medicine, 2023 Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
Hong Seuk Yang +5 more
doaj +4 more sources
Green spectrofluorimetric assay of dantrolene sodium via reduction method: application to content uniformity testing [PDF]
Royal Society Open Science, 2021 Green analysis has turned out to be of a great value in all areas, including pharmaceutical analysis. Thus, it is extremely important to consider the environmental influence of each step in developing any analysis technique.
Nora A. Abdalah +4 more
doaj +4 more sources
Malignant hyperthermia: Dantrolene sodium - A must have
Indian Journal of Anaesthesia, 2012 Alok Sharma +3 more
doaj +6 more sources
A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome [PDF]
JCI Insight, 2021 BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration.
Damien Abreu +16 more
doaj +4 more sources
Comparison Study of Voltammetric Behavior of Muscle Relaxant Dantrolene Sodium on Silver Solid Amalgam and Bismuth Film Electrodes [PDF]
Journal of Analytical Methods in Chemistry, 2017 Voltammetric behavior of muscle relaxant dantrolene sodium (DAN) was studied and the voltammetric methods for its determination using polished and mercury meniscus modified silver solid amalgam electrodes (p-AgSAE and m-AgSAE) as well as using bismuth ...
Renáta Šelešovská +4 more
doaj +4 more sources
A suspected malignant hyperthermia managed without dantrolene sodium [PDF]
Korean Journal of Anesthesiology, 2014 Malignant hyperthermia (MH) is a hypermetabolic reaction that develops in individuals with sensitivity to inhalation anesthetics or depolarizing muscle relaxants [1]. The clinical manifestations of MH are characterized by muscle rigidity, hypercapnia, tachycardia, myoglobinuria, acidosis, rhabdomyolysis, and hyperthermia [1].
Bon-Sung Koo +4 more
doaj +5 more sources
Hydro-organic mobile phase and factorial design application to attain green HPLC method for simultaneous assay of paracetamol and dantrolene sodium in combined capsules [PDF]
BMC Chemistry, 2023 The greenness of any analytical method has become a very important aspect of a good analytical method. However, most chromatographic methods depend on the usage of relatively large amounts of lethal and un-decaying chemicals and solvents.
Nora A. Abdallah +4 more
doaj +2 more sources
Spectrometric Analysis of Dantrolene Sodium. [PDF]
Contact Context, 2023 Dantrolene sodium is a direct-acting skeletal muscle relaxant. Dantrolene sodium for injection is indicated, along with suitable supportive measures, for the management of sudden, severe hypermetabolism of skeletal muscle typical of malignant hyperthermia crises in patients of any age.
Isaacs JT +6 more
europepmc +3 more sources
Hepatotoxicological Evaluation of Dantrolene Sodium [PDF]
Drug and Chemical Toxicology, 1984 The clinical use of dantrolene has been associated with hepatotoxicity, thus the toxicity of dantrolene in Swiss-Webster mice was characterized. Animals were treated orally (po) with single or multiple doses of up to 400 mg/kg of D without any increases in SGPT or alterations in hepato-cellular architecture.
Justin Durham +2 more
openalex +4 more sources