Current clinical application of dantrolene sodium [PDF]
Anesthesia and Pain Medicine, 2023 Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
Hong Seuk Yang +5 more
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A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome [PDF]
JCI Insight, 2021 BACKGROUND Wolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration.
Damien Abreu +16 more
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Malignant hyperthermia and dantrolene sodium [PDF]
Korean Journal of Anesthesiology, 2019 Ha Jung Kim +4 more
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Hydro-organic mobile phase and factorial design application to attain green HPLC method for simultaneous assay of paracetamol and dantrolene sodium in combined capsules [PDF]
BMC Chemistry, 2023 The greenness of any analytical method has become a very important aspect of a good analytical method. However, most chromatographic methods depend on the usage of relatively large amounts of lethal and un-decaying chemicals and solvents.
Nora A. Abdallah +4 more
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Green spectrofluorimetric assay of dantrolene sodium via reduction method: application to content uniformity testing [PDF]
Royal Society Open Science, 2021 Green analysis has turned out to be of a great value in all areas, including pharmaceutical analysis. Thus, it is extremely important to consider the environmental influence of each step in developing any analysis technique.
Nora A. Abdalah +4 more
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Spectrometric Analysis of Dantrolene Sodium. [PDF]
Contact Context, 2023 Dantrolene sodium is a direct-acting skeletal muscle relaxant. Dantrolene sodium for injection is indicated, along with suitable supportive measures, for the management of sudden, severe hypermetabolism of skeletal muscle typical of malignant hyperthermia crises in patients of any age.
Isaacs JT +6 more
europepmc +3 more sources
A Novel Dantrolene Sodium-Loaded Mixed Micelle Containing a Small Amount of Cremophor EL: Characterization, Stability, Safety and Pharmacokinetics [PDF]
Molecules, 2019 Dantrolene sodium (DS) is the only drug specifically used for the treatment of malignant hyperthermia. Nevertheless, its clinical application is significantly restricted due to its aqueous insolubility and the limited formulations available in clinical ...
Wenzhen Jin +8 more
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Malignant hyperthermia: Dantrolene sodium - A must have
Indian Journal of Anaesthesia, 2012 Alok Sharma +3 more
doaj +4 more sources
Comparison Study of Voltammetric Behavior of Muscle Relaxant Dantrolene Sodium on Silver Solid Amalgam and Bismuth Film Electrodes [PDF]
Journal of Analytical Methods in Chemistry, 2017 Voltammetric behavior of muscle relaxant dantrolene sodium (DAN) was studied and the voltammetric methods for its determination using polished and mercury meniscus modified silver solid amalgam electrodes (p-AgSAE and m-AgSAE) as well as using bismuth ...
Renáta Šelešovská +4 more
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Synergistic antiarrhythmic mechanism of I Na-L and RyR2 blockade: normalization of pathological calcium cycling and CaMKII signaling [PDF]
Journal of Translational MedicineBackground Arrhythmias represent a leading cause of mortality among individuals with cardiovascular diseases. Considering the failure of antiarrhythmic drugs targeting single-ion channels in clinical trials, this study aims to evaluate the ...
Miaomiao Ju +7 more
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