Results 91 to 100 of about 198 (126)

A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. [PDF]

Biochim Biophys Acta, 2014
Mislak AC, Frey KM, Bollini M, Jorgensen WL, Anderson KS.   +4 more
europepmc   +1 more source

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. [PDF]

Retrovirology, 2012
Johnson BC, Pauly GT, Rai G, Patel D, Bauman JD, Baker HL, Das K, Schneider JP, Maloney DJ, Arnold E, Thomas CJ, Hughes SH.   +11 more
europepmc   +1 more source

Conformational landscape of the human immunodeficiency virus type 1 reverse transcriptase non-nucleoside inhibitor binding pocket: lessons for inhibitor design from a cluster analysis of many crystal structures. [PDF]

J Med Chem, 2009
Paris KA, Haq O, Felts AK, Das K, Arnold E, Levy RM.   +5 more
europepmc   +1 more source

BindingDB Entry 50014886: Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs.

, 2023
BindingDB
core   +1 more source

An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014. [PDF]

Acta Pharm Sin B, 2015
De Clercq E.
europepmc   +1 more source

Developmental aspects of xenobiotic transformation. [PDF]

Environ Health Perspect, 1976
Klinger W, Muller D.
europepmc   +1 more source

Abstracts of the 14th European Congress of Clinical Microbiology and Infectious Diseases. May 1-4, 2004. Prague, Czech Republic. [PDF]

Clin Microbiol Infect, 2004
europepmc   +1 more source

Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors

, 2014
A series of new diarylpyrimidines (DAPYs) characterized by a halogen atom on the methylene linker between wing I and the central pyrimidine ring was synthesized and evaluated for their anti-HIV activity in MT-4 cell cultures.
Zihong Yan, Hai-Qiu Wu, Wenxue Chen, Yan Wu, Hu‐Ri Piao, Qiuqin He, Fen‐Er Chen, Erik De Clercq, Christophe Pannecouque   +8 more
openalex   +2 more sources

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains

, 2019
The present work follows our preliminary discovery of biphenyl diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Further structural optimization of biphenyl-DAPYs led to the identification of a new series of biphenyl ...
Ya-Li Sang, Sheng Han, Shuwen Han, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen   +6 more
openalex   +2 more sources