Results 61 to 70 of about 112 (105)

Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. [PDF]

J Med Chem, 2012
Sun LQ, Zhu L, Qian K, Qin B, Huang L, Chen CH, Lee KH, Xie L.   +7 more
europepmc   +1 more source

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors. [PDF]

J Med Chem, 2010
Qin B, Jiang X, Lu H, Tian X, Barbault F, Huang L, Qian K, Chen CH, Huang R, Jiang S, Lee KH, Xie L.   +11 more
europepmc   +1 more source

An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014. [PDF]

Acta Pharm Sin B, 2015
De Clercq E.
europepmc   +1 more source

Developmental aspects of xenobiotic transformation. [PDF]

Environ Health Perspect, 1976
Klinger W, Muller D.
europepmc   +1 more source

DAPI Nuclear Staining of Live Worm

BIO-PROTOCOL, 2011
openaire   +1 more source

Abstracts of the 14th European Congress of Clinical Microbiology and Infectious Diseases. May 1-4, 2004. Prague, Czech Republic. [PDF]

Clin Microbiol Infect, 2004
europepmc   +1 more source

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DAPI-inducible common fragile sites

Cytogenetic and Genome Research, 1986
DAPI, a compound specific for the AT bases of DNA, causes gaps and breaks in three human chromosome sites, at the 1q41 1q42 interface, 2q31, and 7p22. It also induces undercondensation of a chromosome site at the 13q21–13q22 interface. The first three sites have the characteristics of “common fragile sites” and are present as gaps and breaks on the ...
PELLICCIA, Franca, ROCCHI, Angela
openaire   +3 more sources

Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs

Bioorganic Chemistry, 2023
To enhance the anti-HIV-1 efficacy and solubility of our previously documented NNRTI 1, a collection of innovative quinoline-substituted DAPY derivatives were devised using heteroaromatic replacement strategy. The results of biological evaluation revealed that the representative compound 5h possessed the highest inhibitory activity against wild-type ...
Ruo-Lan, Zhou, Chao, Yu, Christophe, Pannecouque, Erik, De Clercq, Shuai, Wang, Fen-Er, Chen   +5 more
openaire   +2 more sources

A cautionary (spectral) tail: red-shifted fluorescence by DAPI–DAPI interactions

Biochemical Society Transactions, 2016
The fluorescent dye DAPI is useful for its association with and consequent amplification of an ∼460 nm emission maximum upon binding to dsDNA. Labelling with higher DAPI concentrations is a technique used to reveal Pi polymers [polyphosphate (polyP)], with a red-shift to ∼520–550 nm fluorescence emission.
Omelon, S., Georgiou, J., Habraken, W.
openaire   +3 more sources

CMA/DAPI Banding of Plant Chromosomes

2023
Chromosome banding based on base-specific fluorochromes, mainly double staining with chromomycin A3 (CMA) and 4'-6-diamidino-2-phenylindole (DAPI), has been widely used since the 1970s. This technique allows the differential staining of distinct types of heterochromatin. Afterward, the fluorochromes can be easily removed and leave the preparation ready
Ana Emília, Barros E Silva, Marcelo, Guerra   +1 more
openaire   +2 more sources