Results 11 to 20 of about 8,310 (209)

G-quadruplex formation at human DAT1 gene promoter: Effect of cytosine methylation

Biochemistry and Biophysics Reports, 2023
The dopamine transporter gene (DAT1), a recognized genetic risk factor for attention deficit hyperactivity disorder (ADHD) is principally responsible for the regulation of dopamine synaptic levels and serves as a key target in many psychostimulants drugs.
Nishu Nain, Anju Singh, Shoaib Khan, Shrikant Kukreti   +3 more
doaj   +3 more sources

Methylation Status of the DAT1 Dopamine Transporter Gene in Individuals With Cannabis Use Disorder: Associations With Personality Traits. [PDF]

Genes Brain Behav
This graphical abstract illustrates the relationship between DAT1 gene methylation, personality traits, and cannabis use disorder (CUD). In a sample of 490 study group (212 with CUD and 278 controls), methylation at 33 CpG sites within the DAT1 promoter region was assessed alongside personality traits using the NEO‐FFI and STAI.
Suchanecka A, Recław R, Chmielowiec K, Chmielowiec J, Masiak J, Grzywacz A.   +5 more
europepmc   +2 more sources

Influence of DAT1 Promotor Methylation on Sports Performance [PDF]

Genes, 2021
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factors (TFs) to DNA.
Anna Grzywacz, Krzysztof Chmielowiec, Agnieszka Boroń, Monika Michałowska-Sawczyn, Jolanta Chmielowiec, Grzegorz Trybek, Bożena Mroczek, Katarzyna Leźnicka, Paweł Cieszczyk, Jolanta Masiak   +9 more
openaire   +2 more sources

Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence

Developmental Cognitive Neuroscience, 2018
There is considerable inter-individual variability in the rate at which working memory (WM) develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood.
F. Nemmi, C. Nymberg, F. Darki, T. Banaschewski, A.L.W. Bokde, C. Büchel, H. Flor, V. Frouin, H. Garavan, P. Gowland, A. Heinz, J.-L. Martinot, F. Nees, T. Paus, M.N. Smolka, T.W. Robbins, G. Schumann, T. Klingberg   +17 more
doaj   +5 more sources

DRD4 and DAT1 Polymorphisms Modulate Human Gamma Band Responses [PDF]

Cerebral Cortex, 2006
Gamma oscillations (30-80 Hz) have been demonstrated to be important for perceptual and cognitive processes. Animal and in vitro studies have revealed possible underlying generation mechanisms of the gamma rhythm. However, little is known about the neurochemical modulation of these oscillations during human cognition.
Tamer, Demiralp, Christoph S, Herrmann, M Emin, Erdal, Tolgay, Ergenoglu, Yasemin H, Keskin, Mehmet, Ergen, Hüseyin, Beydagi   +6 more
openaire   +2 more sources

SLC6A3 (DAT1) as a Novel Candidate Biomarker Gene for Suicidal Behavior [PDF]

Genes, 2021
It has been previously shown that the serotonin and dopamine neurotransmitter systems might influence the predisposition to suicidal behavior. This study aims to estimate the contribution of 11 polymorphisms in the genes SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4, DRD2, COMT, and BDNF to suicidal behavior and severity of symptoms of ...
Ekaterina Rafikova, Maria Shadrina, Peter Slominsky, Alla Guekht, Alexey Ryskov, Dmitry Shibalev, Vasiliy Vasilyev   +6 more
openaire   +2 more sources

Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation. [PDF]

PLoS ONE, 2012
BACKGROUND: Dopamine plays an important role in orienting, response anticipation and movement evaluation. Thus, we examined the influence of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O ...
Stephan Bender, Thomas Rellum, Christine Freitag, Franz Resch, Marcella Rietschel, Jens Treutlein, Christine Jennen-Steinmetz, Daniel Brandeis, Tobias Banaschewski, Manfred Laucht   +9 more
doaj   +1 more source

DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics

Pharmacogenomics and Personalized Medicine, 2010
Attention deficit/hyperactivity disorder (ADHD) is a common and potentially very impairing neuropsychiatric disorder of childhood. Statistical genetic studies of twins have shown ADHD to be highly heritable, with the combination of genes and gene by environment interactions accounting for around 80% of phenotypic variance. The initial molecular genetic
Turic, D., Swanson, J., Sonuga-Barke, Edmund J.S.   +2 more
  +9 more sources

Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample

European Psychiatry, 2020
BackgroundThere is a growing number of studies showing interactions between genetic polymorphisms associated with dopaminergic neurotransmission and traumatic life events (TLEs) on a risk of psychotic-like experiences (PLEs).
Dorota Frydecka, Kamila Kotowicz, Łukasz Gawęda, Katarzyna Prochwicz, Joanna Kłosowska, Joanna Rymaszewska, Agnieszka Samochowiec, Jerzy Samochowiec, Piotr Podwalski, Edyta Pawlak-Adamska, Elżbieta Szmida, Andrzej Cechnicki, Błażej Misiak   +12 more
doaj   +1 more source

The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging [PDF]

, 2006
Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in ...
Bernstein, HG, Bunzeck, N, Duzel, E, Fenker, DB, Gundelfinger, ED, Heinze, HJ, Lauer, CJ, Schott, BH, Seidenbecher, CI, Tischmeyer, W   +9 more
core   +1 more source