Results 21 to 30 of about 8,310 (209)

DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]

, 2018
Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario, Claudio D’Addario, Eleonora Marzilli, Esterina Pascale, Giulia Ballarotto, Luca Cerniglia, Renata Tambelli, Silvia Cimino, Walter Adriani, Walter Adriani   +9 more
core   +2 more sources

Association between 5HTT, DAT1, and DRD4 and bipolar disorder in youth [PDF]

Psychiatric Genetics, 2012
Bipolar disorder (BD) in youth is characterized by rapid fluctuation between high and low mood states, severe irritability, and multiple psychiatric comorbidities. Left untreated, affected youth may demonstrate compromised development in social, neurobiological, cognitive, and emotional realms (Miklowitz & Cicchetti 2006).
Cosgrove, V, Miklowitz, D, Rhee, S, Hawkey, C, Corley, R, Haberstick, B, Smolen, A   +6 more
openaire   +3 more sources

The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density

BMC Genetics, 2005
Background A 40-bp variable number of tandem repeats (VNTR) polymorphism exists in the 15th exon of DAT1, the gene encoding the human dopamine transporter (DAT).
Kilts Clinton D, Owens Michael J, VanNess Sidney H   +2 more
doaj   +1 more source

Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts [PDF]

International Journal of Biomedicine, 2019
The purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts Materials and Methods: A total of 191 people of Yakut nationality were ...
Nadezhda I. Pavlova, Khariton A. Kurtanov, PhD, Aleksandra T. Diakonova, Natalia A. Solovyeva, Ljubov' Ah. Sydykova, Yulia A. Solovyeva   +5 more
doaj   +1 more source

A DAT1 gene and APOE ε4 interaction is associated with apathy and structural brain changes in Alzheimer’s Disease [PDF]

Alzheimers Dement
Abstract Background Apathy in patients with Alzheimer’s disease (AD) is associated with significant morbidity. We examined whether interactions between genetic variants related to neurotransmitter systems and regional brain atrophy are associated with apathy in patients with mild cognitive impairment (MCI) and AD.
Malik R, Beaton D, Saykin A, Nho K, Finger E.   +4 more
europepmc   +2 more sources

A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD [PDF]

, 2008
Contains fulltext : 69105.pdf (publisher's version ) (Closed access)Meta-analyses indicate that the gene coding for the dopamine transporter (DAT1 or SLC6A3) is associated with an increased risk for ADHD. The mechanisms of this gene for
Almasy, Altink, American Psychiatric Association, Asherson, Ball, Barkley, Barr, Becker, Bellgrove, Bellgrove, Bellgrove, Benjamini, Boonstra, Brookes, Brookes, Brookes, Brookes, Castellanos, Conners, Cornish, Curran, Demiralp, Diamond, Durston, Durston, Elia, Faraone, Faraone, Faraone, Fossella, Genro, Giros, Goodman, Gottesman, Kim, Lasky-Su, Laucht, Li, Loo, Loo, Madras, Maher, Mill, Mill, Mitchell, Nakatome, Oh, Raymond, Rommelse, Rommelse, Rommelse, Rommelse, Rommelse, Rommelse, Rueda, Schaid, Scheres, Scherk, Schott, Sklar, Sonuga-Barke, Sonuga-Barke, Sonuga-Barke, Swanson, Szobot, Taylor, Thapar, Tobler, Toplak, Vandenbergh, Wohl, Yang, Zhou   +72 more
core   +2 more sources

Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD [PDF]

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractPrevious studies have found heterogeneous association between DAT1‐3′‐UTR‐VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies.
Zhou, K., Chen, W., Buitelaar, J.K., Banaschewski, T., Oades, R.D., Franke, B., Franke, B., Sonuga-Barke, E.J.S., Ebstein, R.P., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Mulas, F., Roeyers, H., Rothenberger, A., Sergeant, J.A., Steinhausen, H.C., Lasky-Su, J., Taylor, E., Brookes, K., Xu, X., Neale, B., Rijsdijk, F., Thompson, M., Asherson, P., Faraone, S.V.   +26 more
openaire   +8 more sources

DNA binding properties of theSaccharomyces cerevisiae DAT1gene product [PDF]

Nucleic Acids Research, 1995
The DAT1 gene of Saccharomyces cerevisiae encodes a DNA binding protein (Dat1p) that specifically recognizes the minor groove of non-alternating oligo(A).oligo(T) tracts. Sequence-specific recognition requires arginine residues found within three perfectly repeated pentads (G-R-K-P-G) of the Dat1p DNA binding domain [Reardon, B. J., Winters, R.
B J, Reardon, D, Gordon, M J, Ballard, E, Winter   +3 more
openaire   +2 more sources

Contribution of Dopamine Transporter Gene Methylation Status to Cannabis Dependency

Brain Sciences, 2020
The susceptibility to cannabis dependency results from the influence of numerous factors such as social, genetic, as well as epigenetic factors. Many studies have attempted to discover a molecular basis for this disease.
Anna Grzywacz, Wojciech Barczak, Jolanta Chmielowiec, Krzysztof Chmielowiec, Aleksandra Suchanecka, Grzegorz Trybek, Jolanta Masiak, Paweł Jagielski, Katarzyna Grocholewicz, Blazej Rubiś   +9 more
doaj   +1 more source

Evidence of an association between 10/10 genotype of DAT1 and endophenotypes of attention deficit/hyperactivity disorder

Neurología (English Edition), 2015
Introduction: Genetic variance of attention deficit hyperactivity disorder (ADHD) is a strong determinant of this disorder. The 40 bp variable number tandem repeat (VNTR) located in the 3′ untranslated region (UTR) of DAT1 gene increases the expression ...
J.A. Agudelo, J.M. Gálvez, D.J. Fonseca, H.E. Mateus, C. Talero-Gutiérrez, A. Velez-Van-Meerbeke   +5 more
doaj   +1 more source