Results 111 to 120 of about 34,675,582 (259)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Learning Robust Output Control Barrier Functions From Safe Expert Demonstrations

IEEE Open Journal of Control Systems
This paper addresses learning safe output feedback control laws from partial observations of expert demonstrations. We assume that a model of the system dynamics and a state estimator are available along with corresponding error bounds, e.g., estimated ...
Lars Lindemann, Alexander Robey, Lejun Jiang, Satyajeet Das, Stephen Tu, Nikolai Matni   +5 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Data-driven deadbeat control with application to output regulation

, 2017
In this paper, a data-driven design of deadbeat controllers is proposed, which is later generalized in different ways to allow for trade-offs between convergence rate and control effort.
Galeani, Sergio, Sassano, Mario, Galeani, S, de Carolis, G, de Carolis, Giovanni, Giovanni de Carolis, Sergio Galeani, Sassano, M, Mario Sassano   +8 more
core   +1 more source

Tracking control of ships based on ADRC−MFAC

Zhongguo Jianchuan Yanjiu
ObjectiveThis paper aims to investigate the complex influence of environmental disturbances on unmanned surface vehicles (USVs) under real ocean conditions, and control USVs to overcome disturbances and realize path following.
Shijie LI, Chengqi XU, Jialun LIU, Ziqian XU, Fanbin MENG   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Bipedal Stepping Controller Design Considering Model Uncertainty: A Data-Driven Perspective

Biomimetics
This article introduces a novel perspective on designing a stepping controller for bipedal robots. Typically, designing a state-feedback controller to stabilize a bipedal robot to a periodic orbit of step-to-step (S2S) dynamics based on a reduced-order ...
Chao Song, Xizhe Zang, Boyang Chen, Shuai Heng, Changle Li, Yanhe Zhu, Jie Zhao   +6 more
doaj   +1 more source