Results 121 to 130 of about 34,675,582 (259)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Publisher Copyright: © 2024 IEEE.This paper proposes a data-driven control (DDC) strategy for nonlinear automated vehicles, employing a multidescription coding (MDC) mechanism based on scalar quantization to address the challenges of data dropouts and ...
Ma, Lifeng +2 more
core +1 more source
An algorithm for closed-loop data-driven simulation
Closed-loop data-driven simulation refers to the problem of constructing trajectories of a closed-loop system directly from data of the plant and a representation of the controller.
Markovsky, Ivan
core +1 more source
A Data-Driven Control Strategy for Urban Express Ramp.
Comput Intell Neurosci, 2021 Zhang L, Zhang M, Ma J, Ge J.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Data-driven Technologies : Challenges for Privacy and Data Protection Law
Data-driven technologies introduce new privacy risks that are currently not (explicitly) addressed by European data protection law. Against this backdrop, the chapter discusses the general conceptual shortcomings of the GDPR, followed by an overview of ...
Ebers, Martin,, Sein, Karin,
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Adaptive Safe Data Driven Control Strategy for Closed Loop System
IEEE AccessDue to the widely studied data driven control in today’s new big data era, this paper combines other innovative considerations into our existed contributions about data driven control, for example, adaptation, safety and switching logic together ...
Wen Ruchun
doaj +1 more source