Results 11 to 20 of about 3,437,744 (312)
Frontiers in Drug Discovery, 2023 Introduction: Suramin is one of the pharmacopeia’s most promiscuous drugs. Originally developed for African trypanosomiasis, suramin was also used for onchocerciasis and it has been proposed as an anticancer agent, antiviral drug, therapy for arthritis ...
Dennis A. Hauser +3 more
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NASCUP: Nucleic Acid Sequence Classification by Universal Probability
IEEE Access, 2021 Nucleic acid sequence classification is a fundamental task in the field of bioinformatics. Due to the increasing amount of unlabeled nucleotide sequences, fast and accurate classification of them on a large scale has become crucial.
Sunyoung Kwon +5 more
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CRISPR-based nucleic acid diagnostics for pathogens [PDF]
, 2022 Pathogenic infections remain the primary threat for human health, especially the global COVID-19 pandemic. It is important to develop rapid, sensitive and multiplexed tools for detecting pathogens and their mutations, particularly the tailor-made ...
Yong, Zhang +5 more
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The Influence of Protein Charge and Molecular Weight on the Affinity of Aptamers
Pharmaceuticals, 2023 Aptamers offer several advantages over antibodies. However, to ensure high affinity and specificity, a better understanding of the interactions between the nucleic-acid-based aptamers and their targets is mandatory.
Alissa Drees +2 more
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MINAS—a database of Metal Ions in Nucleic AcidS [PDF]
Nucleic Acids Research, 2011 Correctly folded into the respective native 3D structure, RNA and DNA are responsible for uncountable key functions in any viable organism. In order to exert their function, metal ion cofactors are closely involved in folding, structure formation and, e.g. in ribozymes, also the catalytic mechanism. The database MINAS, Metal Ions in Nucleic AcidS (http:
Joachim Schnabl +2 more
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NPIDB: nucleic acid—protein interaction database [PDF]
Nucleic Acids Research, 2012 The Nucleic acid-Protein Interaction DataBase (http://npidb.belozersky.msu.ru/) contains information derived from structures of DNA-protein and RNA-protein complexes extracted from the Protein Data Bank (3846 complexes in October 2012). It provides a web interface and a set of tools for extracting biologically meaningful characteristics of ...
Dmitry D. Kirsanov +5 more
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NPIDB: a Database of Nucleic Acids–Protein Interactions [PDF]
Bioinformatics, 2007 AbstractSummary: The database NPIDB (Nucleic Acids—Protein Interaction DataBase) contains information derived from structures of DNA–protein and RNA–protein complexes extracted from PDB (1834 complexes in July 2007). It is organized as a collection of files in PDB format and is equipped with a web-interface and a set of tools for extracting ...
Sergei A. Spirin +3 more
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Algorithms for Nucleic Acid Sequence Design [PDF]
, 2010 Motivated by a growing field of research focused on programming function into biomolecules, we seek to decrease the cost of high-quality rational nucleic acid sequence design while increasing its versatility and availability.
Zadeh, Joseph N.
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NAPP: the Nucleic Acid Phylogenetic Profile Database [PDF]
Nucleic Acids Research, 2011 Nucleic acid phylogenetic profiling (NAPP) classifies coding and non-coding sequences in a genome according to their pattern of conservation across other genomes. This procedure efficiently distinguishes clusters of functional non-coding elements in bacteria, particularly small RNAs and cis-regulatory RNAs, from other conserved sequences.
Alban Ott +3 more
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Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]
, 1968 With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
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