Results 81 to 90 of about 514,201 (245)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
IEEE AccessTopic modeling is an unsupervised learning technique, that is extensively used for discovering latent topics in huge text corpora. However, existing models often fall short in cross-lingual scenarios, particularly for morphologically rich and low ...
Sania Aftar +3 more
doaj +1 more source
Discovering Topic Representative Terms for Short Text Clustering
IEEE Access, 2019 Clustering short texts are one of the most important text analysis methods to help extract knowledge from online social media platforms, such as Twitter, Facebook, and Weibo.
Shuiqiao Yang, Guangyan Huang, Borui Cai
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Analyzing OSHA Construction Accident Reports Using BERTopic Topic Modeling for Thematic Insights
BuildingsHazards at construction sites can lead to severe accidents, posing significant risks to worker safety, financial stability, and public confidence in industry safety standards.
Yuntao Cao +6 more
doaj +1 more source
Online Tensor Methods for Learning Latent Variable Models [PDF]
, 2015 We introduce an online tensor decomposition based approach for two latent variable modeling problems namely, (1) community detection, in which we learn the latent communities that the social actors in social networks belong to, and (2) topic modeling, in
Anandkumar, Animashree +3 more
core +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
A New Algorithm of Mining High Utility Sequential Pattern in Streaming Data
International Journal of Computational Intelligence Systems, 2019 High utility sequential pattern (HUSP) mining has emerged as a novel topic in data mining, its computational complexity increases compared to frequent sequences mining and high utility itemsets mining.
Huijun Tang, Yangguang Liu, Le Wang
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source