Results 101 to 110 of about 10,061 (190)

Multi‐Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies

Integrative Zoology, EarlyView.
Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun   +4 more
wiley   +1 more source

Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience

Biology Open, 2016
Stress granules are cytoplasmic foci that directly respond to the protein synthesis status of the cell. Various environmental insults, such as oxidative stress or extreme heat, block protein synthesis; consequently, mRNA will stall in translation, and ...
Cecilia Zampedri, Maryana Tinoco-Cuellar, Samantha Carrillo-Rosas, Abigail Diaz-Tellez, Jose Luis Ramos-Balderas, Francisco Pelegri, Ernesto Maldonado   +6 more
doaj   +1 more source

Inhibin βB Mediates Oligotrophic Adaptation via Regulating Muscle Satellite Cell Proliferation and Differentiation in Schizopygopsis younghusbandi

Integrative Zoology, EarlyView.
① Nutrient deficiency upregulates inhibin βB, activating SMAD signaling to promote p21. Increased p21 inhibits mcm2/mcm4/mcm5 and cyclin E2, inducing G1‐phase arrest, slowing growth, and reducing energy consumption. ② Inhibin βB also upregulates pdgf‐c, which induces α‐SMA, leading to muscle satellite cell fibrosis.
Weiqiang Li, He Gao, Chaowei Zhou, Luo Lei, Junting Li, Chao Ma, Zitu Ma, Mengwei Yao, Kexin Ma, Yunpeng Xiang, Yan Zhou, Yongrui Lu, Da Ji, Minghong Wei, Luohao Xu, Zhaofang Han, Haiping Liu   +16 more
wiley   +1 more source

The nuclear GUCT domain-containing DEAD-box RNA helicases govern gametophytic and sporophytic development in Physcomitrium patens. [PDF]

Plant Mol Biol, 2021
Perroud PF, Demko V, Demko V, Ako AE, Khanal R, Bokor B, Pavlovič A, Jásik J, Johansen W.   +8 more
europepmc   +1 more source

Functional assessment of inherited myeloid neoplasm‐associated SAMD9L germline variants via Monoallelic CRISPR modelling

British Journal of Haematology, EarlyView.
Summary While the majority of myeloid neoplasms are sporadic, the increasing application of germline genetic testing has led the World Health Organization to designate ‘Myeloid malignancies with germline predisposition’ as a distinct clinical entity, carrying major implications for clinical care and research.
Elena Vuelta, Alessandro Liquori, Matias Morín, Lucia Soletto, Miguel Ángel Marugal, Marta Santiago‐Balsera, Miguel Gallardo, Miguel Ángel Moreno‐Pelayo, José Cervera, Alejandra Sanjuan‐Pla   +9 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast. [PDF]

Genes (Basel), 2021
Mokdadi M, Abdelkrim YZ, Banroques J, Huvelle E, Oualha R, Yeter-Alat H, Guizani I, Barhoumi M, Tanner NK.   +8 more
europepmc   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Characterisation of the DEAD Box RNA-Helicase Dbp10

, 2023
Masterarbeit Universität Graz ...
openaire   +1 more source