Results 111 to 120 of about 10,578 (207)
The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics
Clinical Genetics, EarlyView.The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree +18 more
wiley +1 more source
Plasmodium falciparum DDX31 is DNA helicase localized in nucleolus
Heliyon, 2019 Malaria is a major infectious disease and is responsible for millions of infections every year. As drug resistance strains of Plasmodium species are emerging, there is an urgent need to understand the parasite biology and identify new drug targets ...
Rahena Yasmin +3 more
doaj +1 more source
The multiple lives of DEAD-box RNA helicase DP103/DDX20/Gemin3
Biochemical Society Transactions, 2018 Gemin3, also known as DDX20 or DP103, is a DEAD-box RNA helicase which is involved in more than one cellular process. Though RNA unwinding has been determined in vitro, it is surprisingly not required for all of its activities in cellular metabolism. Gemin3 is an essential gene, present in Amoeba and Metazoa.
Curmi, Frank, Cauchi, Ruben J.
openaire +3 more sources
DEAD-box RNA Helicases: the microRNA managers of breast cancer: DOI: 10.14800/rd.846
, 2015 The roles of non-coding RNAs in cancers, microRNA (miRNA) especially, have sparked interest in the field of RNA research in recent years. The once widely accepted ‘central dogma of genetics’ describing the flow of cellular protein expression is now being
Wanpei Cai, Chao Wang, Jen Nee Goh, Ser Yue Loo, Celestial T Yap, Alan Prem Kumar
core
, 2017 As RNA helicases da família DEAD-box são enzimas que alteram as estruturas secundárias do RNA e auxiliam a formação de complexos ribonucleoproteicos, e são muito importantes em processos basais como a degradação dos RNAs e a biogênese dos ribossomos. A &#
Durán, Angel Alfonso Aguirre
core +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Degron-mediated proteolysis of CrhR-like DEAD-box RNA helicases in cyanobacteria. [PDF]
J Biol Chem, 2022 Whitman BT +6 more
europepmc +1 more source
The FEBS Journal, EarlyView.Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia +7 more
wiley +1 more source
The FEBS Journal, EarlyView.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source