Results 131 to 140 of about 15,822 (213)

The role of DEAD- and DExH-box RNA helicases in neurodevelopmental disorders

Frontiers in Molecular Neuroscience
Neurodevelopmental disorders (NDDs) represent a large group of disorders with an onset in the neonatal or early childhood period; NDDs include intellectual disability (ID), autism spectrum disorders (ASD), attention deficit hyperactivity disorders (ADHD),
Johannes Lederbauer, Johannes Lederbauer, Sarada Das, Amelie Piton, Davor Lessel, Davor Lessel, Hans-Jürgen Kreienkamp   +6 more
doaj   +1 more source

Degron-mediated proteolysis of CrhR-like DEAD-box RNA helicases in cyanobacteria. [PDF]

J Biol Chem, 2022
Whitman BT, Murray CRA, Whitford DS, Paul SS, Fahlman RP, Glover MJN, Owttrim GW.   +6 more
europepmc   +1 more source

A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function. [PDF]

, 2017
We report on a homozygous frameshift deletion in DDX59 (c.185del: p.Phe62fs*13) in a family presenting with orofaciodigital syndrome phenotype associated with a broad neurological involvement characterized by microcephaly, intellectual disability ...
Ashokkumar, B, Bello, OD, Bettencourt, C, Botia, JA, Cutrupi, MC, Dipasquale, V, Efthymiou, S, Houlden, H, Mankad, K, Manole, A, Manti, S, Maurya, B, Mukherjee, A, Mutsuddi, M, Ryten, M, Salpietro, V, Vandrovcova, J, Wiethoff, S   +17 more
core   +1 more source

Vernalization regulatory network identifies potential novel functions for genes in the HvVRN2 locus

New Phytologist, EarlyView.
Summary Flowering is controlled by environmental and genetic factors. Vernalization requirement in barley (Hordeum vulgare L.) is determined by the allele in HvVRN1 and the presence of locus HvVRN2, which consists of two zinc‐finger and CONSTANS‐like domains (ZCCT) genes: HvVRN2a and HvVRN2b.
Francesc Montardit‐Tarda, Irene Puyó, Bruno Contreras‐Moreira, Ildikó Karsai, Philippa Borrill, Ana M. Casas, Ernesto Igartua   +6 more
wiley   +1 more source

DEAD box RNA helicases crucial regulators of gene expression and oncogenesis

Frontiers in Bioscience, 2016
DEAD box protein family of RNA helicases are vital players of RNA metabolism, and constitute the largest family of RNA helicases. Members of this family share nine conserved motifs including an Asp-Glu-Ala-Asp motif, giving this family its characteristic name as DEAD box RNA helicases.
Moumita, Sarkar, Mrinal Kanti, Ghosh
openaire   +2 more sources

Methionine Synthase Positively Regulates Plant Defence to Both RNA and DNA Viruses and Is Useful for Developing Broad‐Spectrum Antiviral Resistance in Crops

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses frequently cause severe economic losses in worldwide crop production. Developing broad‐spectrum resistance is the most efficient approach for controlling plant viral diseases. In this work, we found that the 17K protein of barley yellow dwarf viruses (BYDVs), which has multiple functions in viral pathogenesis including acting as ...
Zhaohui Wang, Kunpu Zhang, Chi Zhang, Jin Yang, Bei Li, Lina Wang, Zhenghao Shi, Rui Guo, Shuai Zhang, Kaiqi Gao, Jianing Li, Xiaohuan Jin, Xiang Ji, Huihui Bi, Liyuan You, Huaibing Jin, Daowen Wang   +16 more
wiley   +1 more source

Linking the DEAD‐box RNA helicase Ded1p to cellular RNA targets

The FASEB Journal, 2012
RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all aspects of eukaryotic RNA metabolism. In vitro, helicases bind or remodel RNA or RNA‐protein complexes in an ATP‐dependent fashion, but how these activities are used in the cellular function of these enzymes has remained elusive. This is mainly because RNA targets and
openaire   +1 more source

Transcript correlation analysis for the identification of novel plant genes involved in iron metabolism and beyond: what next?

Plant Biology, EarlyView.
Transcript correlation analysis allowed the identification of several key nodes in the complex regulatory network of plant iron metabolism. Abstract Arabidopsis thaliana was the first plant genome to be fully sequenced, almost a quarter of a century ago, thanks to The Arabidopsis Genome Initiative, with contributions from scientists worldwide.
I. Murgia, P. Morandini
wiley   +1 more source

Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience

Biology Open, 2016
Stress granules are cytoplasmic foci that directly respond to the protein synthesis status of the cell. Various environmental insults, such as oxidative stress or extreme heat, block protein synthesis; consequently, mRNA will stall in translation, and ...
Cecilia Zampedri, Maryana Tinoco-Cuellar, Samantha Carrillo-Rosas, Abigail Diaz-Tellez, Jose Luis Ramos-Balderas, Francisco Pelegri, Ernesto Maldonado   +6 more
doaj   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source