Results 141 to 150 of about 10,578 (207)

The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum

, 1998
DEAD-box RNA helicases, defined by the sequence Asp–Glu–Ala–Asp (DEAD, in single-letter amino-acid code), regulate RNA unwinding and secondary structure in an ATP-dependent manner in vitro [1] and control mRNA stability and protein translation.
Machesky, Laura M., Kay, Robert R., Insall, Robert H.   +2 more
core   +1 more source

Osimertinib Resistance in EGFR‐Mutated Non–Small Cell Lung Cancer: Mechanisms and Therapeutic Strategies

MedComm, Volume 7, Issue 7, July 2026.
This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley   +1 more source

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Uncovering the Multifaceted Roles of DDX21: Bridging Biological Insights and Medical Applications

Journal of Bio-X Research
DDX21 belongs to the DEAD-box (DDX) family of helicases but deviates from the characteristic sequence Asp–Glu–Ala–Asp (DEAD) to Asp–Glu–Val–Asp. In addition to the typical helicase activity associated with the DEAD-box family, DDX21 also possesses ...
Jinze Shen, Ruixiu Chen, Kailin Guo, Chenming Zhong, Shiwei Duan   +4 more
doaj   +1 more source

Cucumber green mottle mosaic virus: A persistent seed‐borne threat to cucurbits

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Cucumber green mottle mosaic virus (CGMMV) is a highly stable, seed‐borne tobamovirus that threatens global cucurbit production. Its efficient mechanical and seed transmission, long‐term environmental persistence, and the spread of Clade II CGMMV isolates drive its rapid dissemination and cause severe yield losses.
Esperanza Gea‐Caballero, Miguel A. Aranda   +1 more
wiley   +1 more source

Linking the DEAD‐box RNA helicase Ded1p to cellular RNA targets

The FASEB Journal, 2012
RNA helicases are ubiquitous, highly conserved enzymes that participate in nearly all aspects of eukaryotic RNA metabolism. In vitro, helicases bind or remodel RNA or RNA‐protein complexes in an ATP‐dependent fashion, but how these activities are used in the cellular function of these enzymes has remained elusive. This is mainly because RNA targets and
openaire   +1 more source

Characterization of DEAD-box family of RNA helicases in tomato provides insights into their roles in biotic and abiotic stresses

, 2018
In plants, RNA helicases play significant roles in growth, development and stress response. In a previous study, a three-fold upregulation of a DEAD-box RNA helicase in a tomato cultivar tolerant to Tomato leaf curl New Delhi virus (ToLCNDV) as compared ...
Dulani, Priya, Jha, Sarita, Kuba, Shweta; id_orcid, Muthamilarasan, Mehanathan, Prasad, Manoj, Mathur, Saloni, Sharma, Namisha, Pandey, Saurabh, Chaudhry, Vaishali   +8 more
core   +1 more source

The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli, Bünyamin Akgül   +1 more
wiley   +1 more source

Decoding GUN1 in plastid‐to‐nucleus signaling: what it doesn't, what it does, and why it matters

New Phytologist, Volume 251, Issue 1, Page 81-88, July 2026.
Publication history of plant GUN1 research. Summary Plastid‐to‐nucleus retrograde signaling coordinates nuclear gene expression with the developmental and physiological state of plastids. GENOMES UNCOUPLED 1 (GUN1), a chloroplast‐localized PPR‐SMR protein, remains a central yet poorly understood component of this network.
Marco Wendler, Dario Leister, Tatjana Kleine   +2 more
wiley   +1 more source

The Biology and Biochemistry of PhoH2 proteins

, 2013
PhoH2 proteins are found in a diverse range of organisms. To date little is known about these proteins and the role they play in the organisms in which they reside.
Andrews, Emma Sophie Vout
core