Results 111 to 120 of about 9,305 (205)
Design of a robotic decapping module
The need for new technical solutions for automating the preanalytical stage in clinical laboratories is discussed, in particular, one of the most labor-intensive and potentially dangerous regularly performed operations - decapping (opening) test tubes ...
I. A. Kyurkchu +6 more
core +1 more source
Coactivator regulation of active site chemistry in the mRNA decapping enzyme Dcp2 [PDF]
, 2014 Regulation of mRNA half-life is a crucial control point of gene expression. Removal of the protective 5' methylguanosine cap is a committed step in the 5'-3' decay pathway, which is carried out by the decapping enzyme Dpc2.
Aglietti, Robin
core
miRISC recruits decapping factors to miRNA targets to enhance their degradation
, 2013 MicroRNA (miRNA)-induced silencing complexes (miRISCs) repress translation and promote degradation of miRNA targets. Target degradation occurs through the 5'-to-3' messenger RNA (mRNA) decay pathway, wherein, after shortening of the mRNA poly(A) tail ...
Izaurralde, E. +3 more
core +1 more source
Functional analysis of decapping and EVH1/WH1 domains in dDcp1,Drosophila Decapping protein 1.
, 2007 根據蛋白質序列的比對分析，果蠅CG11183 基因的人類同源物SMIF是一個轉錄共同調控蛋白，透過N端的EVH1/WH1 domain與Smad4作用，參與變形生長因子貝它的信息傳遞路徑。CG11183因此最先被命為dSMIF，但是CG11183參與果蠅變形生長因子貝它信息傳遞路徑的證據並不確實。人類SMIF之後亦被證實是一個去頭蓋酵素而被命名為hDcp1a.
李沛珍, Lee, Pei-Chen
core
Structural and Enzymatic Characterization of the Yeast mRNA Decapping Enzyme, Dcp2 [PDF]
, 2010 mRNA turnover represents a fundamental point of post-transcriptional control of gene expression in eukaryotes. Decapping is a highly regulated, irreversible step in mRNA decay and is involved in many different decay pathways.
Jones, Brittnee Noelle
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Creatine mitigates neurogenesis impairment caused by defective DcpS decapping
Scientific ReportsBiallelic mutations in the DCPS gene disrupting the decapping activity of the scavenger decapping protein DcpS, leads to neurodevelopmental deficiencies and intellectual disability.
Jun Yang +5 more
doaj +1 more source
The Role of Enzyme-Coactivator Interactions in the Regulation of mRNA Decapping [PDF]
, 2011 Messenger RNA degradation is a fundamental aspect of eukaryotic gene expression, regulation, and quality control. Removal of the 5' N7-methylguanosine (m7G) cap structure by the decapping enzyme Dcp2 is an irreversible step committing an mRNA to ...
Borja, Mark
core
ChemistryEuropeDinucleoside tetraphosphates (Np4N) have been reported as 5′ caps of RNAs in bacteria and mammalian cells. The guanosine‐based version (Gp4N) resembles the canonical eukaryotic 5′ cap (m7Gp3N), which is a central platform for cap‐interacting proteins ...
Cedrik Kühling +5 more
doaj +1 more source
Genome-wide mapping of DCP2-dependent 5' cap footprints in <i>Arabidopsis thaliana</i>. [PDF]
NAR Genom BioinformShukla N +4 more
europepmc +1 more source
Neuron decapping characterization by atomic force microscopy: a topological systematic analysis
, 1995 We tested a new approach to cell decapping on rat cerebellar neurones, and observed its effects on cell topography by atomic force microscopy (AFM). The results clearly demonstrate the effectiveness of our decapping approach, and also the ability of AFM ...
De Stasio G +4 more
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