Results 101 to 110 of about 9,305 (205)
Patient Preference and Adherence, 2021 Andreas Schneider,1 Philipp Richard,1 Philippe Mueller,1 Christoph Jordi,1 Mary Yovanoff,2 Jakob Lange1 1Ypsomed AG, Burgdorf, Switzerland; 2Design Science, Philadelphia, PA, USACorrespondence: Jakob LangeYpsomed AG, Brunnmattstrasse 6, Burgdorf 3401 ...
Schneider A +5 more
doaj
Cell Reports, 2018 Summary: Aging is accompanied by a pervasive collapse of proteostasis, while reducing general protein synthesis promotes longevity across taxa. Here, we show that the eIF4E isoform IFE-2 is increasingly sequestered in mRNA processing (P) bodies during ...
Matthias Rieckher +4 more
doaj +1 more source
CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA
Molecular Therapy: Nucleic AcidsCo-transcriptional capping allows exogenous mRNAs to yield robust protein expression. Identifying additional mRNA modifications that further boost protein output will be crucial for developing more efficacious mRNA therapies.
Zachary F. Mandell +13 more
doaj +1 more source
mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection [PDF]
, 2017 mRNA decay is an important step in gene regulation, environmental responsiveness, and mRNA quality control. One such quality control pathway, Nonsense-mediated mRNA Decay (NMD), targets transcripts whose translation terminates prematurely.
Celik, Alper
core +1 more source
Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs
Cell Reports, 2019 Summary: RNA polymerase II transcripts receive a protective 5ʹ,5ʹ-triphosphate-linked 7-methylguanosine (m7G) cap, and its removal by decapping enzymes like DCP2 is critical for initiation of RNA decay.
Hao Wu +7 more
doaj +1 more source
Biochemical analysis of the mRNA scavenger decapping enzymes
, 2007 The modulation of mRNA degradation is an essential determining point for regulation of gene expression. Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNAs.
Liu, Shin-Wu
core +1 more source
Decapping assay with DXO mutants. [PDF]
, 2018 Three mutant DXO proteins were generated and tested in a decapping assay using GpppG-RNA as substrate. Wild-type DXO as well as the R145A-Q146A-E147A and R177A-M185A mutants readily cleave this cap structure.
Julien Rainville-Sirois +25 more
core +1 more source
Structural and biochemical characterization of eukaryotic mRNA decapping activators [PDF]
, 2014 In eukaryotes, mRNA turnover starts with the truncation of 3′ poly(A) tail and proceeds with either 3′-to-5′ degradation by the exosome complex or with decapping followed by 5′-to-3′ degradation by Xrn1.
Sharif, Humayun
core +1 more source
Capping and Decapping Series of Boranes
International Journal of Chemistry, 2015 Whereas many of the capped series of carbonyl clusters of transition metals are known, those of corresponding borane series are unknown. These include the monocapped, bicapped, tricapped, tetracapped and so on. This paper attempts to correlate selected capped series of the carbonyl series with the hypothetical corresponding ones of boranes using 14n ...
openaire +1 more source
Differential utilization of decapping enzymes in mammalian mRNA decay pathways
, 2011 mRNA decapping is a crucial step in the regulation of mRNA stability and gene expression. Dcp2 is an mRNA decapping enzyme that has been widely studied. We recently reported the presence of a second mammalian cytoplasmic decapping enzyme, Nudt16. Here we
Mangen Song +2 more
core +1 more source