Results 81 to 90 of about 9,305 (205)

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

eLife
The mRNA 5'-cap structure removal by the decapping enzyme DCP2 is a critical step in gene regulation. While DCP2 is the catalytic subunit in the decapping complex, its activity is strongly enhanced by multiple factors, particularly DCP1, which is the ...
Ting-Wen Chen, Hsiao-Wei Liao, Michelle Noble, Jing-Yi Siao, Yu-Hsuan Cheng, Wei-Chung Chiang, Yi-Tzu Lo, Chung-Te Chang   +7 more
doaj   +1 more source

Transcriptome maps of general eukaryotic RNA degradation factors

eLife, 2019
RNA degradation pathways enable RNA processing, the regulation of RNA levels, and the surveillance of aberrant or poorly functional RNAs in cells. Here we provide transcriptome-wide RNA-binding profiles of 30 general RNA degradation factors in the yeast ...
Salma Sohrabi-Jahromi, Katharina B Hofmann, Andrea Boltendahl, Christian Roth, Saskia Gressel, Carlo Baejen, Johannes Soeding, Patrick Cramer   +7 more
doaj   +1 more source

Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. [PDF]

PLoS ONE, 2012
Long-term tobacco use causes nicotine dependence via the regulation of a wide range of genes and is accompanied by various health problems. Studies in mammalian systems have revealed some key factors involved in the effects of nicotine, including ...
Jing Ren, Jinghan Sun, Yunpeng Zhang, Tong Liu, Qingzhong Ren, Yan Li, Aike Guo   +6 more
doaj   +1 more source

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Infections by Pseudomonas aeruginosa are a major cause of severe morbidity and mortality in immunocompromised patients and people with cystic fibrosis, largely due to the pathogen's ability to resist antibiotic treatment and to deploy multiple virulence strategies that promote persistence in the host.
Gianluca Pistoia, Matteo Cervoni, Flavia Catalano, Francesca Troilo, Francesca Guidi, Eleonora Comparini, Giuseppina Mignogna, Carlo Travaglini‐Allocatelli, Alessandro Giuffrè, Antonio Coluccia, Francesco Imperi, Adele Di Matteo, Giorgio Giardina   +12 more
wiley   +1 more source

Functional analysis of mRNA scavenger decapping enzymes [PDF]

RNA, 2004
Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. Two major decapping enzymes have been identified. The hDcp2 protein catalyzes hydrolysis of the 5′ cap linked to an RNA moiety, whereas the scavenger decapping enzyme, DcpS, functions on a cap structure lacking the RNA moiety.
Shin-Wu, Liu, Xinfu, Jiao, Hudan, Liu, Meigang, Gu, Christopher D, Lima, Megerditch, Kiledjian   +5 more
openaire   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Molecular mechanisms of messenger RNA decapping

, 2019
The work presented in this doctoral thesis describes biochemical and structural investigations of the molecular mechanisms of messenger RNA decapping—a critical step in one of the major cytoplasmic messenger RNA decay pathways. Decapping, mediated by the
Muthukumar, S. ; https://orcid.org/
core   +1 more source

End labeling of enzymatically decapped mRNA

Nucleic Acids Research, 1977
A method is presented for rapid and efficient 5' end labeling with 32P of capped mRNAs, by a series of three enzymatic reactions: the blocking nucleotide of the cap structure is removed by tobacco acid pyrophosphatase, and after dephosphorylation with alkaline phosphatase the 5' end is labeled with gamma-32-P-ATP and T4 polynucleotide kinase.
A, Efstratiadis, J N, Vournakis, H, Donis-Keller, G, Chaconas, D K, Dougall, F C, Kafatos   +5 more
openaire   +3 more sources

Genome‐Wide Association Study in European Beech (Fagus sylvatica L.) for Drought Stress Related Traits

Physiologia Plantarum, Volume 178, Issue 5, September/October 2026.
ABSTRACT Genome‐wide association studies (GWAS) aim to identify loci associated with different traits, which could be evaluated in subsequent studies and later be prioritized in individual and seed stand selection. In trees, traits are measured at maturity or are only available after a long time, and juvenile‐mature correlations are often unknown ...
Mila Tost, Ourania Grigoriadou‐Zormpa, Selina Wilhelmi, Timothy Beissinger, Mehdi Ben Targem, Markus Müller, Henning Wildhagen, Alexandru Lucian Curtu, Oliver Gailing   +8 more
wiley   +1 more source

HPat provides a link between deadenylation and decapping in metazoa

, 2010
Decapping of eukaryotic messenger RNAs (mRNAs) occurs after they have undergone deadenylation, but how these processes are coordinated is poorly understood.
Elisa Izaurralde, Izaurralde, E., Braun, J., Gabrielle Haas, Igreja, C., Haas, G., Tritschler, F., Joerg E. Braun, Nishihara, T., Cátia Igreja, Felix Tritschler, Tadashi Nishihara   +11 more
core   +1 more source