Results 61 to 70 of about 9,305 (205)
CSDE1 controls gene expression through the miRNA-mediated decay machinery
Life Science Alliance, 2020 CSDE1 is a new component of miRNA-induced silencing complex and interacts with DCP1–DCP2 decapping machinery with potential roles in miRNA-mediated target degradation.
Pavan Kumar Kakumani +5 more
doaj +1 more source
The Mimivirus L375 Nudix enzyme hydrolyzes the 5' mRNA cap.
PLoS ONE, 2021 The giant Mimivirus is a member of the nucleocytoplasmic large DNA viruses (NCLDV), a group of diverse viruses that contain double-stranded DNA (dsDNA) genomes that replicate primarily in eukaryotic hosts.
Grace Kago, Susan Parrish
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard +3 more
wiley +1 more source
The Control of mRNA Decapping and P-Body Formation [PDF]
Molecular Cell, 2008 mRNA decapping is a critical step in eukaryotic cytoplasmic mRNA turnover. Cytoplasmic mRNA decapping is catalyzed by Dcp2 in conjunction with its coactivator Dcp1 and is stimulated by decapping enhancer proteins. mRNAs associated with the decapping machinery can assemble into cytoplasmic mRNP granules called processing bodies (PBs).
Franks, Tobias M., Lykke-Andersen, Jens
openaire +2 more sources
EcoEnergy, EarlyView.Carbon‐negative carbon nanotubes produced by molten CO2 electrolysis offer a low‐cost, high‐performance alternative to graphite in Li‐ion battery anodes. Replacing conventional carbon materials with electrolytic CNTs can improve battery capacity and charging performance while reducing costs and contributing to carbon mitigation.
Gad Licht, Stuart Licht
wiley +1 more source
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation [PDF]
, 2021 Cells organize biochemical processes into biological condensates. P-bodies are cytoplasmic condensates that are enriched in enzymes important for mRNA degradation and have been identified as sites of both storage and decay.
Tibble, Ryan W +6 more
core +1 more source
Multiple mRNA Decapping Enzymes in Mammalian Cells [PDF]
Molecular Cell, 2010 Regulation of RNA degradation plays an important role in the control of gene expression. One mechanism of eukaryotic mRNA decay proceeds through an initial deadenylation followed by 5' end decapping and exonucleolytic decay. Dcp2 is currently believed to be the only cytoplasmic decapping enzyme responsible for decapping of all mRNAs.
Song, Man-Gen +2 more
openaire +2 more sources
Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms
, 2010 Eukaryotic mRNA degradation often occurs in a process whereby translation initiation is inhibited and the mRNA is targeted for decapping. In yeast cells, Pat1, Scd6, Edc3, and Dhh1 all function to promote decapping by an unknown mechanism(s).
Haiwei Song (163763) +4 more
core +2 more sources
Smart Molecules, EarlyView.The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang +8 more
wiley +1 more source
Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs
Viruses, 2017 All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of Rous sarcoma virus (RSV),
Vidya Balagopal, Karen L. Beemon
doaj +1 more source