Results 61 to 70 of about 7,630 (176)

Decapping enzymes STOP “cancer” ribosomes in their tracks [PDF]

The EMBO Journal, 2018
The production of ribosomes plays a central role in regulating cell cycle progression and cancer proliferation. A new study by Gaviraghi et al (2018) shows that mRNA decapping coactivator PNRC1 acts as a tumor suppressor by regulating ribosome biogenesis.
Jeffrey S Mugridge, John D Gross
openaire   +4 more sources

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

Nature Communications, 2018
The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators.
Jeffrey S. Mugridge, Ryan W. Tibble, Marcin Ziemniak, Jacek Jemielity, John D. Gross   +4 more
doaj   +1 more source

mRNA Decapping and 5′-3′ Decay Contribute to the Regulation of ABA Signaling in Arabidopsis thaliana

Frontiers in Plant Science, 2018
Defects in RNA processing and degradation pathways often lead to developmental abnormalities, impaired hormonal signaling and altered resistance to abiotic and biotic stress.
Izabela Wawer, Anna Golisz, Aleksandra Sulkowska, Dorota Kawa, Anna Kulik, Joanna Kufel   +5 more
doaj   +1 more source

Exploring the role of RRM domains and conserved aromatic residues in RGG motif  of eIF4G-binding translation repressor protein Sbp1 [version 2; peer review: 3 approved, 1 approved with reservations]

Wellcome Open Research, 2020
Background: Mechanisms of mRNA fate decisions play an important role in determining if a given mRNA will be translated, stored or degraded upon arrival to cytoplasm.
Nupur Bhatter, Rajan Iyyappan, Purusharth I Rajyaguru   +2 more
doaj   +1 more source

Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p. [PDF]

PLoS Biology, 2010
Intron-containing pre-mRNAs are normally retained and processed in the nucleus but are sometimes exported to the cytoplasm and degraded by the nonsense-mediated mRNA decay (NMD) pathway as a consequence of their inclusion of intronic in-frame termination
Shuyun Dong, Allan Jacobson, Feng He
doaj   +1 more source

Arabidopsis DXO1‐ and RNMT1‐Mediated m7G Capping of mRNA Modulates ABA Response

Plant, Cell &Environment, Volume 49, Issue 8, Page 5358-5372, August 2026.
ABSTRACT Eukaryotic mRNA carries an N7‐methylguanosine (m⁷G) 5′ cap that is essential for mRNA stability and function. Although traditionally viewed as a constitutive process, m⁷G capping is increasingly recognized as dynamically regulated to control gene expression in response to environmental stimuli.
Shumin Liang, Shangwei Wu, Chen Xiao, Hailei Zhang, Wuzhen Liu, Kefan Hu, Huijuan Tan, Hongwei Guo, Liming Xiong, Jiansheng Liang, Yiji Xia   +10 more
wiley   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

General Translational Repression by Activators of mRNA Decapping [PDF]

Cell, 2005
Translation and mRNA degradation are affected by a key transition where eukaryotic mRNAs exit translation and assemble an mRNP state that accumulates into processing bodies (P bodies), cytoplasmic sites of mRNA degradation containing non-translating mRNAs, and mRNA degradation machinery.
Coller, Jeff, Parker, Roy
openaire   +2 more sources

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Fast Decap Allocation Based on Algebraic Multigrid [PDF]

2006 IEEE/ACM International Conference on Computer Aided Design, 2006
Decap (decoupling capacitor) is an effective technique for suppressing power supply noise. Nevertheless, over-usage of decap usually causes excessive power dissipation. Therefore, the total decap area needs to be minimized subject to power supply noise constraints.
Cheng Zhuo, Jiang Hu, Min Zhao, Kangsheng Chen   +3 more
openaire   +1 more source