Results 41 to 50 of about 9,305 (205)
The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme [PDF]
RNA, 2003 A major pathway of eukaryotic mRNA turnover initiates with deadenylation, which allows a decapping reaction leading to 5′–3′ exonucleolytic degradation. A key control point in this pathway is the decapping of the mRNA. Two proteins, Edc1 and Edc2, were genetically identified previously as enhancers of the decapping reaction.
David, Schwartz +2 more
openaire +2 more sources
Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing.
PLoS Pathogens, 2022 The mRNA 5' cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is tightly regulated
Michael Ly +4 more
doaj +1 more source
Composition and function of P bodies in Arabidopsis thaliana
Frontiers in Plant Science, 2014 mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of ...
Luis David Maldonado-Bonilla
doaj +1 more source
Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. [PDF]
PLoS Pathogens, 2015 Aberrant viral RNAs produced in infected plant cells serve as templates for the synthesis of dsRNAs. The derived virus-related small interfering RNAs (siRNA) mediate cleavage of viral RNAs by post-transcriptional gene silencing (PTGS), thus blocking ...
Jian Ye +8 more
doaj +1 more source
Wellcome Open Research, 2021 Background: RNA binding proteins play crucial role in determining if a given mRNA will be translated, stored, or degraded. Sbp1 is an RGG-motif containing protein that is implicated in affecting mRNA decapping and translation.
Nupur Bhatter +3 more
doaj +1 more source
Regulation of mRNA decapping across atomic and mesoscopic scales [PDF]
, 2021 During transcription in the nucleus, messenger RNA (mRNA) is endowed withmodifications that serve as important markers for its regulation in the cell.
Tibble, Ryan William
core +1 more source
A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs
Biomolecules, 2020 The complexity of the transcriptome is governed by the intricate interplay of transcription, RNA processing, translocation, and decay. In eukaryotes, the removal of the 5’-RNA cap is essential for the initiation of RNA degradation.
Florian Abele +8 more
doaj +1 more source
General decapping activators target different subsets of inefficiently translated mRNAs [PDF]
, 2019 The Dcp1-Dcp2 decapping enzyme and the decapping activators Pat1, Dhh1, and Lsm1 regulate mRNA decapping, but their mechanistic integration is unknown. We analyzed the gene expression consequences of deleting PAT1, LSM1, or DHH1, or the DCP2 C-terminal ...
Wu, Chan +3 more
core +1 more source
Zdorovʹe Rebenka, 2022 This scientific review deals with the mechanisms of action of cytoplasmic microRNAs, namely post-transcriptional silencing: recruitment of the DCP1-DCP2 decapping complex and disruption of the interaction of mRNA with ribosomes.
A.E. Abaturov, V.L. Babуch
doaj +1 more source
Yeast Sm-like proteins function in mRNA decapping and decay [PDF]
, 2000 One of the main mechanisms of messenger RNA degradation in eukaryotes occurs by deadenylation-dependent decapping which leads to 5'-to-3' decay1, 2. A family of Sm-like (Lsm) proteins has been identified, members of which contain the 'Sm' sequence motif,
Tharun, Sundaresan +11 more
core +1 more source