Results 31 to 40 of about 9,305 (205)
Targeting mRNA Decapping in AML [PDF]
Cancer Cell, 2018 In this issue of Cancer Cell, Yamauchi et al. identify a dependency of acute myeloid leukemia (AML) on DCPS, which catalyzes the final step of 3'-to-5' mRNA decay and is implicated in numerous aspects of RNA metabolism. DCPS is targetable with a clinical inhibitor, underscoring the translational importance of this discovery.
Akihide, Yoshimi, Omar, Abdel-Wahab
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Dcp2 C-terminal Cis-Binding Elements Control Selective Targeting of the Decapping Enzyme by Forming Distinct Decapping Complexes [preprint] [PDF]
, 2021 This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5’ to 3’ decay, but the molecular ...
Wu, Chan, Jacobson, Allan, He, Feng
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Targeting an mRNA for Decapping [PDF]
Molecular Cell, 2001 A critical step in the turnover of yeast mRNAs is decapping. Two yeast proteins, Dcp1p and Dcp2p, are absolutely required for decapping, although their precise roles in the decapping reaction have not been established. To determine the function of both Dcp1p and Dcp2p in decapping, we purified recombinant versions of these proteins from Escherichia ...
Tharun, Sundaresan, Parker, Roy
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The DEAD-box protein Dhh1 promotes decapping by slowing ribosome movement. [PDF]
PLoS Biology, 2012 Translational control and messenger RNA (mRNA) decay represent important control points in the regulation of gene expression. In yeast, the major pathway for mRNA decay is initiated by deadenylation followed by decapping and 5'-3' exonucleolytic ...
Thomas Sweet +2 more
doaj +1 more source
Molecular Cell, 2012 In this issue of Molecular Cell, Brannan et al. (2012) propose a novel function for RNA-decapping and transcription termination in aborting "divergent" promoter-proximal elongation complexes.
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Eukaryotic mRNA decapping factors: molecular mechanisms and activity
, 2022 Decapping is the enzymatic removal of 5' cap structures from mRNAs in eukaryotic cells. Cap structures normally enhance mRNA translation and stability, and their excision commits an mRNA to complete 5'-3' exoribonucleolytic digestion and generally ends ...
Jacobson, Allan, He, Feng
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Arabidopsis DXO1- and RNMT1-Mediated m<sup>7</sup>G Capping of mRNA Modulates ABA Response. [PDF]
Plant Cell EnvironABSTRACT Eukaryotic mRNA carries an N7‐methylguanosine (m⁷G) 5′ cap that is essential for mRNA stability and function. Although traditionally viewed as a constitutive process, m⁷G capping is increasingly recognized as dynamically regulated to control gene expression in response to environmental stimuli.
Liang S +10 more
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, 2022 A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Wu, Chan, Jacobson, Allan, He, Feng
core +1 more source
DECAPS: Detail-Oriented Capsule Networks [PDF]
, 2020 Capsule Networks (CapsNets) have demonstrated to be a promising alternative to Convolutional Neural Networks (CNNs). However, they often fall short of state-of-the-art accuracies on large-scale high-dimensional datasets. We propose a Detail-Oriented Capsule Network (DECAPS) that combines the strength of CapsNets with several novel techniques to boost ...
Aryan Mobiny +3 more
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Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity [PDF]
, 2015 mRNA decapping is a central step in eukaryotic mRNA decay that simultaneously shuts down translation initiation and activates mRNA degradation. A major complex responsible for decapping consists of the decapping enzyme Dcp2 in association with decapping ...
Erickson, Stacy L +6 more
core +1 more source