Results 31 to 40 of about 7,630 (176)
The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme [PDF]
RNA, 2003 A major pathway of eukaryotic mRNA turnover initiates with deadenylation, which allows a decapping reaction leading to 5′–3′ exonucleolytic degradation. A key control point in this pathway is the decapping of the mRNA. Two proteins, Edc1 and Edc2, were genetically identified previously as enhancers of the decapping reaction.
David, Schwartz +2 more
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Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. [PDF]
PLoS Pathogens, 2015 Aberrant viral RNAs produced in infected plant cells serve as templates for the synthesis of dsRNAs. The derived virus-related small interfering RNAs (siRNA) mediate cleavage of viral RNAs by post-transcriptional gene silencing (PTGS), thus blocking ...
Jian Ye +8 more
doaj +1 more source
Attacked from All Sides: RNA Decay in Antiviral Defense
Viruses, 2017 The innate immune system has evolved a number of sensors that recognize viral RNA (vRNA) to restrict infection, yet the full spectrum of host-encoded RNA binding proteins that target these foreign RNAs is still unknown.
Jerome M. Molleston, Sara Cherry
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Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing.
PLoS Pathogens, 2022 The mRNA 5' cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is tightly regulated
Michael Ly +4 more
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Wellcome Open Research, 2021 Background: RNA binding proteins play crucial role in determining if a given mRNA will be translated, stored, or degraded. Sbp1 is an RGG-motif containing protein that is implicated in affecting mRNA decapping and translation.
Nupur Bhatter +3 more
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Composition and function of P bodies in Arabidopsis thaliana
Frontiers in Plant Science, 2014 mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of ...
Luis David Maldonado-Bonilla
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A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs
Biomolecules, 2020 The complexity of the transcriptome is governed by the intricate interplay of transcription, RNA processing, translocation, and decay. In eukaryotes, the removal of the 5’-RNA cap is essential for the initiation of RNA degradation.
Florian Abele +8 more
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Translation of Enzymically Decapped Messenger RNA [PDF]
European Journal of Biochemistry, 1977 An enzymic procedure was used to remove the 7‐methylguanosine diphosphate moiety at the 5′ ends of rabbit hemoglobin mRNA and mouse immunoglobulin light‐chain mRNA. Evidence was obtained that the procedure, which involves the use of polynucleotide kinase, does not result in any further degradation of the mRNA.The enzymically decapped mRNA was as ...
K A, Abraham, A, Pihl
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Structural insights into dpCoA-RNA decapping by NudC [PDF]
RNA Biology, 2021 Various kinds of cap structures, such as m7G, triphosphate groups, NAD and dpCoA, protect the 5' terminus of RNA. The cap structures bond covalently to RNA and affect its stability, translation, and transport. The removal of the caps is mainly executed by Nudix hydrolase family proteins, including Dcp2, RppH and NudC. Numerous efforts have been made to
Wei Zhou +6 more
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Zdorovʹe Rebenka, 2022 This scientific review deals with the mechanisms of action of cytoplasmic microRNAs, namely post-transcriptional silencing: recruitment of the DCP1-DCP2 decapping complex and disruption of the interaction of mRNA with ribosomes.
A.E. Abaturov, V.L. Babуch
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