Results 11 to 20 of about 9,305 (205)
Eukaryotic mRNA Decapping Activation
Frontiers in Genetics, 2022 The 5′-terminal cap is a fundamental determinant of eukaryotic gene expression which facilitates cap-dependent translation and protects mRNAs from exonucleolytic degradation.
Thomas Duchaine, Elva Vidya
exaly +5 more sources
Conserved and divergent features of human mRNA decapping revealed by biochemical reconstitution [PDF]
Nature CommunicationsDecapping is a critical step in mRNA decay, but the mechanisms regulating human decapping enzyme DCP2 remain poorly understood. Here, we reconstitute the human decapping network using full-length recombinant proteins and compare it to the yeast system ...
Eric A. J. Simko +4 more
doaj +2 more sources
Pby1 is a direct partner of the Dcp2 decapping enzyme [PDF]
Nucleic Acids Research, 2020 International audienceMost eukaryotic mRNAs harbor a characteristic 5 m 7 GpppN cap that promotes pre-mRNA splicing, mRNA nucleocytoplasmic transport and translation while also protecting mRNAs from exonucleolytic attacks.
Ulryck, Nathalie +6 more
core +5 more sources
Control of mRNA decapping by autoinhibition [PDF]
Nucleic Acids Research, 2018 5’ mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are understood, the role of abundant intrinsically disordered regions (IDRs) is lacking.
Tibble, Ryan W +7 more
core +5 more sources
Targeted mRNA degradation by deadenylation-independent decapping [PDF]
Molecular Cell, 2004 International audienceModulating the rate of mRNA degradation is a fast and efficient way to control gene expression. In a yeast strain deleted of EDC3, a component of the decapping machinery conserved in eukaryotes, the transcript coding the ribosomal ...
Fromont-Racine, Micheline +3 more
core +4 more sources
Biochemical and functional characterization of orf virus decapping protein OV71 [PDF]
Virology JournalBackground Nudix enzymes constitute a family of hydrolases that share a conserved Nudix motif, which catalyzes the hydrolysis of nucleoside diphosphates linked to another moiety X.
Mandanda N. Mthethwa +8 more
doaj +2 more sources
Mille viae in eukaryotic mRNA decapping
Current Opinion in Structural Biology, 2017 Cellular mRNA levels are regulated via rates of transcription and decay. Since the removal of the mRNA 5'-cap by the decapping enzyme DCP2 is generally an irreversible step towards decay, it requires regulation.
Oliver Weichenrieder +5 more
core +5 more sources
mRNA decapping proteins regulate EIN2-dependent ethylene signaling in arabidopsis [PDF]
Frontiers in Plant ScienceEthylene signaling regulates plant growth and stress adaptation through a well-defined pathway, yet its mechanistic complexity remains underexplored. Here, we identify two mRNA decapping proteins, DCP1 and DCP2, as novel regulators of canonical ethylene ...
Bai Hui Jiang +14 more
doaj +2 more sources
Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways [PDF]
eLifeDegradation of many yeast mRNAs involves decapping by the Dcp1:Dcp2 complex. Previous studies on decapping activators Edc3 and Scd6 suggested their limited roles in mRNA decay.
Rakesh Kumar +7 more
doaj +2 more sources
HPat a decapping activator interacting with the miRNA effector complex.
PLoS ONE, 2013 Animal miRNAs commonly mediate mRNA degradation and/or translational repression by binding to their target mRNAs. Key factors for miRNA-mediated mRNA degradation are the components of the miRNA effector complex (AGO1 and GW182) and the general mRNA ...
Elisabeth Barišić-Jäger +4 more
doaj +3 more sources