Results 21 to 30 of about 9,305 (205)

Decapping enzymes STOP “cancer” ribosomes in their tracks [PDF]

The EMBO Journal, 2018
The production of ribosomes plays a central role in regulating cell cycle progression and cancer proliferation. A new study by Gaviraghi et al (2018) shows that mRNA decapping coactivator PNRC1 acts as a tumor suppressor by regulating ribosome ...
Gross, John D, John D Gross, Jeffrey S Mugridge, Mugridge, Jeffrey S   +3 more
core   +6 more sources

New insights into the control of mRNA decapping

Trends in Biochemical Sciences, 2006
mRNA decapping irreversibly targets mRNAs for fast decay. Cap removal is catalyzed by decapping protein Dcp2 but also requires Dcp1. Recently, two groups have provided a first glimpse of the regulation mechanism of this crucial step in gene expression ...
Bertrand Séraphin, Ernesto Simon, Séraphin, Bertrand, Camier, Sylvie, Sylvie Camier, Simon, Ernesto   +5 more
core   +4 more sources

RNA degradation triggered by decapping is largely independent of initial deadenylation

EMBO Journal
RNA stability, important for eukaryotic gene expression, is thought to depend on deadenylation rates, with shortened poly(A) tails triggering decapping and 5′ to 3′ degradation.
Abdelkader Namane, Karsten Weis, Cosmin Saveanu   +2 more
exaly   +2 more sources

Regulation of mammalian mRNA decapping

, 2011
The modulation of mRNA degradation plays a critical role for regulation of gene expression. A major mRNA decay pathway in mammals proceeding from the 5' to 3' end is initiated with shortening of 3' poly (A) tail, followed by the cleavage of the 5' cap ...
Li, You
core   +2 more sources

Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes

eLife, 2022
A single Dcp1–Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5′ to 3′ decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Feng He, Chan Wu, Allan Jacobson
doaj   +1 more source

Selective Destabilization of Transcripts by mRNA Decapping Regulates Oocyte Maturation and Innate Immunity Gene Expression during Ageing in C. elegans

Biology, 2023
Removal of the 5′ cap structure of RNAs (termed decapping) is a pivotal event in the life of cytoplasmic mRNAs mainly catalyzed by a conserved holoenzyme, composed of the catalytic subunit DCP2 and its essential cofactor DCP1.
Fivos Borbolis, Dimitra Ranti, Maria-Despina Papadopoulou, Sofia Dimopoulou, Apostolos Malatras, Ioannis Michalopoulos, Popi Syntichaki   +6 more
doaj   +1 more source

Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

eLife, 2023
Degradation of most yeast mRNAs involves decapping by Dcp1/Dcp2. DEAD-box protein Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to enhanced degradation, and as a translational repressor, but its functions in ...
Anil Kumar Vijjamarri, Xiao Niu, Matthew D Vandermeulen, Chisom Onu, Fan Zhang, Hongfang Qiu, Neha Gupta, Swati Gaikwad, Miriam L Greenberg, Paul J Cullen, Zhenguo Lin, Alan G Hinnebusch   +11 more
doaj   +1 more source

A unique mRNA decapping complex in trypanosomes [PDF]

Nucleic Acids Research, 2023
AbstractRemoval of the mRNA 5′ cap primes transcripts for degradation and is central for regulating gene expression in eukaryotes. The canonical decapping enzyme Dcp2 is stringently controlled by assembly into a dynamic multi-protein complex together with the 5′-3′exoribonuclease Xrn1.
Susanne Kramer, Natalia Katarzyna Karolak, Johanna Odenwald, Bernardo Gabiatti, Paula Andrea Castañeda Londoño, Anna Zavřelová, Eden Ribeiro Freire, Kayo Schemiko Almeida, Silke Braune, Claudia Moreira, Amelie Eder, Carina Goos, Mark Field, Mark Carrington, Fabiola Holetz, Maria Wiktoria Górna, Martin Zoltner   +16 more
openaire   +5 more sources

Transcript-Specific Decapping and Regulated Stability by the Human Dcp2 Decapping Protein [PDF]

Molecular and Cellular Biology, 2008
mRNA decapping is a critical step in the control of mRNA stability and gene expression and is carried out by the Dcp2 decapping enzyme. Dcp2 is an RNA binding protein that must bind RNA in order to recognize the cap for hydrolysis. We demonstrate that human Dcp2 (hDcp2) preferentially binds to a subset of mRNAs and identify sequences at the 5' terminus
You, Li, Man-Gen, Song, Megerditch, Kiledjian   +2 more
openaire   +2 more sources

mRNA decapping in Saccharomyces cerevisiae

, 2000
The major pathway of mRNA degradation in yeast occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. The products of the DCP1 and DCP2 genes are required for mRNA decapping.
Dunckley, Travis Lee
core   +4 more sources