Results 131 to 140 of about 7,630 (176)
RNMT-dependent RNA cap methylation in health and disease. [PDF]
Biochem JMills JG, Hepburn LA, Cowling VH.
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Mind the cap: Detecting degradation impurities in synthetic mRNAs. [PDF]
Mol Ther Nucleic AcidsNielsen D +3 more
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Aptamer-based assay for high-throughput substrate profiling of RNA decapping enzymes. [PDF]
Nucleic Acids ResGrab K +5 more
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RNA anchoring of Upf1 facilitates recruitment of Dcp2 in the NMD decapping complex. [PDF]
Nucleic Acids ResRuiz-Gutierrez N +7 more
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Monitoring mRNA Decapping Activity
Methods, 1999mRNA decapping is a common step shared between two important mRNA decay pathways in yeast, Saccharomyces cerevisiae. To investigate how mRNAs are decapped, we have developed an assay that can be easily used to measure the decapping activity. This assay has been used to isolate yeast strains with altered decapping activities.
Michael Wormington +2 more
exaly +3 more sources
Annual Review of Biochemistry, 2004
▪ Abstract Eukaryotic mRNAs are primarily degraded by removal of the 3′ poly(A) tail, followed either by cleavage of the 5′ cap structure (decapping) and 5′->3′ exonucleolytic digestion, or by 3′ to 5′ degradation. mRNA decapping represents a critical step in turnover because this permits the degradation of the mRNA and is a site of numerous ...
Jeff, Coller, Roy, Parker
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▪ Abstract Eukaryotic mRNAs are primarily degraded by removal of the 3′ poly(A) tail, followed either by cleavage of the 5′ cap structure (decapping) and 5′->3′ exonucleolytic digestion, or by 3′ to 5′ degradation. mRNA decapping represents a critical step in turnover because this permits the degradation of the mRNA and is a site of numerous ...
Jeff, Coller, Roy, Parker
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WIREs RNA, 2010
AbstractDecapping is a critical step in the control of mRNA stability and the regulation of gene expression. Two major decapping enzymes involved in mRNA turnover have been identified, each functioning in one of the two exonucleolytic mRNA decay pathways in eukaryotic cells.
You, Li, Megerditch, Kiledjian
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AbstractDecapping is a critical step in the control of mRNA stability and the regulation of gene expression. Two major decapping enzymes involved in mRNA turnover have been identified, each functioning in one of the two exonucleolytic mRNA decay pathways in eukaryotic cells.
You, Li, Megerditch, Kiledjian
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Decapping the message: a beginning or an end
Biochemical Society Transactions, 2006Removal of the mRNA 5′ cap is an important step in the regulation of mRNA stability. mRNAs are degraded by at least two distinct exonucleolytic decay pathways, one from the 5′ end, and the second from the 3′ end. Two major cellular decapping enzymes have been identified, and each primarily functions in one of the two decay pathways.
H, Liu, M, Kiledjian
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Nature Structural & Molecular Biology, 2016
The degradation of mRNAs involves removal of the 5′ protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the field. New data suggest how the chemistry of decapping is controlled and orchestrated
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The degradation of mRNAs involves removal of the 5′ protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the field. New data suggest how the chemistry of decapping is controlled and orchestrated
openaire +2 more sources