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The mRNA decapping complex is buffered by nuclear localization
Journal of Cell Science, 2021ABSTRACT mRNA decay is a key step in regulating the cellular proteome. Processing bodies (P-bodies) are thought to be sites of mRNA decay and/or storage. P-body units assemble into P-body granules under stress conditions. How this assembly is regulated, however, remains poorly understood.
Kiril Tishinov, Anne Spang
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2001
Publisher Summary This chapter reviews the process of mRNA decapping including the properties of a yeast decapping enzyme, encoded by the DCP1 gene, and the proteins that modulate decapping rates in vivo. In addition, the chapter also describes techniques for analyzing mRNA decapping in vitro.
T, Dunckley, R, Parker
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Publisher Summary This chapter reviews the process of mRNA decapping including the properties of a yeast decapping enzyme, encoded by the DCP1 gene, and the proteins that modulate decapping rates in vivo. In addition, the chapter also describes techniques for analyzing mRNA decapping in vitro.
T, Dunckley, R, Parker
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New insights into the control of mRNA decapping
Trends in Biochemical Sciences, 2006mRNA decapping irreversibly targets mRNAs for fast decay. Cap removal is catalyzed by decapping protein Dcp2 but also requires Dcp1. Recently, two groups have provided a first glimpse of the regulation mechanism of this crucial step in gene expression. Resolution of the yeast Dcp2 structure has enabled identification of the residues that are important ...
Simon, Ernesto +2 more
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Mille viae in eukaryotic mRNA decapping
Current Opinion in Structural Biology, 2017Cellular mRNA levels are regulated via rates of transcription and decay. Since the removal of the mRNA 5'-cap by the decapping enzyme DCP2 is generally an irreversible step towards decay, it requires regulation. Control of DCP2 activity is likely effected by two interdependent means: by conformational control of the DCP2-DCP1 complex, and by assembly ...
Valkov, E., Jonas, S., Weichenrieder, O.
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Leakage Optimized DECAP Design for FPGAs
APCCAS 2006 - 2006 IEEE Asia Pacific Conference on Circuits and Systems, 2006On-chip decoupling capacitors (Decaps) are widely used to mitigate on-chip power supply noise. At and below 100nm on-chip decaps face leakage and area overhead problems associated with it and is estimated to increase with technology scaling. A recent work has proposed a gated decap structure to reduce leakage in decaps.
Balaji Vaidyanathan +4 more
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Developmental Effects of Decapping
Science, 2007STKE The balance between synthesis and degradation controls mRNA abundance. Goeres et al. have found that the 5′ to 3′ mRNA degradation pathway involves an mRNA decapping complex and is crucial for seedling development in Arabidopsis . The phenotypes of varicose ( vcs ) and trident ( tdt ) mutants were similar: defective leaf formation with vein ...
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Science's STKE, 2007
The balance between synthesis and decay controls protein abundance at multiple levels. Goeres et al . found that a specific 5′→3′ mRNA degradation pathway involving an mRNA decapping complex was crucial for seedling development in Arabidopsis thaliana . The phenotypes of mutants in the
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The balance between synthesis and decay controls protein abundance at multiple levels. Goeres et al . found that a specific 5′→3′ mRNA degradation pathway involving an mRNA decapping complex was crucial for seedling development in Arabidopsis thaliana . The phenotypes of mutants in the
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mRNA decapping activities and their biological roles
Biochimie, 1996The 5' cap structure of eukaryotic mRNAs is significant for a variety of cellular events and also serves to protect mRNAs from premature degradation. Analysis of mRNA decay in Saccharomyces cerevisiae has shown that removal of the 5' cap structure is a key step in the turnover of many yeast mRNAs, and that this decapping is carried out by Dcp1p.
T E, LaGrandeur, R, Parker
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Plant Science Letters, 1973
Abstract Removing the root cap of Zea mays prevents geoperception. But georeactivity may be regained after several hours. The time necessary to recover geosensitivity (GRT) is calculated using an intercept method. GRT is less for the short roots than for longer ones.
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Abstract Removing the root cap of Zea mays prevents geoperception. But georeactivity may be regained after several hours. The time necessary to recover geosensitivity (GRT) is calculated using an intercept method. GRT is less for the short roots than for longer ones.
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Normal and Aberrantly Capped mRNA Decapping
2012Messenger RNAs transcribed by RNA polymerase II are modified at their 5'-end by the cotranscriptional addition of a 7-methylguanosine (m(7)G) cap. The cap is an important modulator of gene expression and the mechanism and components involved in its removal have been extensively studied.
Megerditch, Kiledjian +2 more
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