Results 181 to 190 of about 9,305 (205)
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Normal and Aberrantly Capped mRNA Decapping
2012Messenger RNAs transcribed by RNA polymerase II are modified at their 5'-end by the cotranscriptional addition of a 7-methylguanosine (m(7)G) cap. The cap is an important modulator of gene expression and the mechanism and components involved in its removal have been extensively studied.
Megerditch, Kiledjian +2 more
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Premature translational termination triggers mRNA decapping
Nature, 1994The degradation of messenger RNA in eukaryotic cells is initiated by endonucleolytic cleavage or by shortening of the poly(A) tail, which for some mRNAs activates a deadenylation-dependent decapping reaction. One type of rapid mRNA degradation in eukaryotes is caused by premature termination of translation.
D, Muhlrad, R, Parker
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Methods in enzymology, 2009
The modulation of mRNA decay is a critical determinant in the regulation of gene expression. mRNAs in eukaryotes are primarily degraded by two major exonucleolytic pathways: the 5' to 3'-and the 3' to 5'-pathways, both of which are initiated by removal of the polyadenylated (poly(A)) tail.
Shin-Wu, Liu +3 more
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The modulation of mRNA decay is a critical determinant in the regulation of gene expression. mRNAs in eukaryotes are primarily degraded by two major exonucleolytic pathways: the 5' to 3'-and the 3' to 5'-pathways, both of which are initiated by removal of the polyadenylated (poly(A)) tail.
Shin-Wu, Liu +3 more
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RNA decapping inside and outside of processing bodies
Current Opinion in Cell Biology, 2005Decapping is a central step in eukaryotic mRNA turnover. Recent studies have identified several factors involved in catalysis and regulation of decapping. These include the following: an mRNA decapping complex containing the proteins Dcp1 and Dcp2; a nucleolar decapping enzyme, X29, involved in the degradation of U8 snoRNA and perhaps of other capped ...
Christy, Fillman, Jens, Lykke-Andersen
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Gravity perception in decapped roots of Zea mays
Planta, 1982Time-lapse photography and light microscopy were used to determine whether or not sedimentation of the newly developed amyloplasts in the apex of Zea mays L. roots occurred at the time when geotropic responsiveness reappears following removal of the cap.
S K, Hillman, M B, Wilkins
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Structural and functional insights into eukaryotic mRNA decapping
WIREs RNA, 2010AbstractThe control of messenger RNA (mRNA) translation and degradation is important in regulation of eukaryotic gene expression. In the general and specialized mRNA decay pathways which involve 5′→3′ decay, decapping is the central step because it is the controlling gate preceding the actual degradation of mRNA and is a site of numerous control inputs.
Sharon H M, Ling +2 more
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Assessing Messenger RNA Decapping in Cellular Extracts
2004Removal of the 5' cap from a messenger RNA (mRNA) is an integral part of all mRNA decay pathways and can be a highly regulated event. Assays designed to assess decapping in vitro need to effectively resolve four products of mRNA decay: 7meGpppG produced by 3'-5' shortening of the transcript by the exosome, 7meGMP produced by the scavenger decapping ...
Naomi, Bergman +5 more
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Decap: Deprivileging Programs by Reducing Their Capabilities
Proceedings of the 25th International Symposium on Research in Attacks, Intrusions and Defenses, 2022Md. Mehedi Hasan 0007 +2 more
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The EDC4‐XRN1 interaction controls P‐body dynamics to link mRNA decapping with decay
EMBO Journal, 2023William R Brothers +2 more
exaly
Eukaryotic mRNA decapping factors: molecular mechanisms and activity
FEBS Journal, 2023Allan Jacobson
exaly