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Dissemination, Communication, Exploitation Action Plan (DECAP)
Document produced by the EIT Community Synergies Cluster Task Force on Comms to set common practices in communication efforts - this document includes feedback and discsussions carried out with other Clusters (Review in M18)
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Annual Review of Biochemistry, 2004
▪ Abstract Eukaryotic mRNAs are primarily degraded by removal of the 3′ poly(A) tail, followed either by cleavage of the 5′ cap structure (decapping) and 5′->3′ exonucleolytic digestion, or by 3′ to 5′ degradation. mRNA decapping represents a critical step in turnover because this permits the degradation of the mRNA and is a site of numerous ...
Jeff, Coller, Roy, Parker
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▪ Abstract Eukaryotic mRNAs are primarily degraded by removal of the 3′ poly(A) tail, followed either by cleavage of the 5′ cap structure (decapping) and 5′->3′ exonucleolytic digestion, or by 3′ to 5′ degradation. mRNA decapping represents a critical step in turnover because this permits the degradation of the mRNA and is a site of numerous ...
Jeff, Coller, Roy, Parker
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WIREs RNA, 2010
AbstractDecapping is a critical step in the control of mRNA stability and the regulation of gene expression. Two major decapping enzymes involved in mRNA turnover have been identified, each functioning in one of the two exonucleolytic mRNA decay pathways in eukaryotic cells.
You, Li, Megerditch, Kiledjian
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AbstractDecapping is a critical step in the control of mRNA stability and the regulation of gene expression. Two major decapping enzymes involved in mRNA turnover have been identified, each functioning in one of the two exonucleolytic mRNA decay pathways in eukaryotic cells.
You, Li, Megerditch, Kiledjian
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Monitoring mRNA Decapping Activity
Methods, 1999mRNA decapping is a common step shared between two important mRNA decay pathways in yeast, Saccharomyces cerevisiae. To investigate how mRNAs are decapped, we have developed an assay that can be easily used to measure the decapping activity. This assay has been used to isolate yeast strains with altered decapping activities.
S, Zhang +4 more
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Premature translational termination triggers mRNA decapping
Nature, 1994The degradation of messenger RNA in eukaryotic cells is initiated by endonucleolytic cleavage or by shortening of the poly(A) tail, which for some mRNAs activates a deadenylation-dependent decapping reaction. One type of rapid mRNA degradation in eukaryotes is caused by premature termination of translation.
D, Muhlrad, R, Parker
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Mille viae in eukaryotic mRNA decapping
Current Opinion in Structural Biology, 2017Cellular mRNA levels are regulated via rates of transcription and decay. Since the removal of the mRNA 5'-cap by the decapping enzyme DCP2 is generally an irreversible step towards decay, it requires regulation. Control of DCP2 activity is likely effected by two interdependent means: by conformational control of the DCP2-DCP1 complex, and by assembly ...
Valkov, E., Jonas, S., Weichenrieder, O.
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2001
Publisher Summary This chapter reviews the process of mRNA decapping including the properties of a yeast decapping enzyme, encoded by the DCP1 gene, and the proteins that modulate decapping rates in vivo. In addition, the chapter also describes techniques for analyzing mRNA decapping in vitro.
T, Dunckley, R, Parker
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Publisher Summary This chapter reviews the process of mRNA decapping including the properties of a yeast decapping enzyme, encoded by the DCP1 gene, and the proteins that modulate decapping rates in vivo. In addition, the chapter also describes techniques for analyzing mRNA decapping in vitro.
T, Dunckley, R, Parker
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Nature Structural & Molecular Biology, 2016
The degradation of mRNAs involves removal of the 5′ protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the field. New data suggest how the chemistry of decapping is controlled and orchestrated
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The degradation of mRNAs involves removal of the 5′ protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the field. New data suggest how the chemistry of decapping is controlled and orchestrated
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Decap aware sleep transistor design
Proceedings of the 12th IEEE Mediterranean Electrotechnical Conference (IEEE Cat No 04CH37521) DCAS-04), 2004Multithreshold CMOS (MTCMOS) has been a proven methodology to reduce leakage power in DSM designs. Previously lumped sleep transistors were designed for worst case condition, and hence occupied a large area. To reduce the area, cluster based sleep transistor design was proposed which takes into account simultaneous switching within the circuit blocks ...
null Ramaprasath Vilangudipitchai +1 more
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