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Decorin-Mediated Effects in Cancer Cell Biology
Connective Tissue Research, 2008Decorin is a multifunctional molecule of the extracellular matrix. Among the multitude of assigned functions the most intriguing is the ability to inhibit the growth and the metastasis of a wide range of cancer cells in vitro. Decorin was established to directly interact with EGFR and erb2, inducing protracted receptor internalization, which results in
Alexandros, Zafiropoulos +1 more
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Structural Change in Decorin with Skin Aging
Connective Tissue Research, 2006Decorin, the main proteoglycan in skin, has a small size with a core protein of approximately 40kDa and one chondroitin sulfate/dermatan sulfate glycosaminoglycan (GAG) chain. The main function of decorin is to regulate the collagen matrix assembly. Decorin is distributed along collagen fibrils with the core protein and the decorin GAG chain controls ...
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Decorin: matrix-based pan-cancer tumor suppressor
Molecular and Cellular BiochemistryStudies have shown that decorin is a potent pan-cancer tumor suppressor that is under-expressed in most cancers. Decorin interacts with receptor tyrosine kinases and functions as a pan-receptor tyrosine kinase inhibitor, thereby suppressing oncogenic signals.
Sandeep, Appunni +7 more
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Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis
Matrix Biology, 2021Qiu-hua Zhang +2 more
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Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
Nature Medicine, 1996Yoshitaka Isaka
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