Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 [PDF]
Cell Reports, 2017 The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose ...
Angela Castoldi +25 more
doaj +7 more sources
CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway. [PDF]
PLoS Pathogens, 2015 Collaboration between heterogeneous pattern recognition receptors (PRRs) leading to synergistic coordination of immune response is important for the host to fight against invading pathogens.
Juin-Hua Huang +7 more
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TNF-α/NF-κB mediated upregulation of Dectin-1 in hyperglycemic obesity: implications for metabolic inflammation and diabetes [PDF]
Journal of Translational MedicineBackground Dectin-1, a key innate immune receptor, plays a critical role in cellular responses and is implicated in chronic inflammation and metabolic syndromes.
Ashraf Al Madhoun +8 more
doaj +2 more sources
Role of Dectin-1 in peripheral nerve injury [PDF]
Frontiers in Cellular Neuroscience, 2022 Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood.
Angela Yu-Huey Hsu +5 more
doaj +2 more sources
IL-6 regulates the polarization of Dectin-1 macrophages to weaken immune escape in thyroid cancer [PDF]
Journal of Translational MedicineBackground Immune evasion is a critical barrier to effective treatment of thyroid carcinoma (TC). Macrophage polarization plays a pivotal role in shaping the tumor microenvironment (TME). This study aimed to elucidate how IL-6 regulates Dectin-1–mediated
Xianzhao Deng +5 more
doaj +2 more sources
Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS [PDF]
HeliyonMicroglia have been increasingly implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Dectin-1, encoded by the Clec7a gene, is highly upregulated in a specific microglial response state called disease-associated ...
Justin You +9 more
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Signalling C-Type Lectins in Antimicrobial Immunity [PDF]
, 2013 Funding: This work was funded by the Wellcome Trust, Medical Research Council and the University of Aberdeen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Brown, Gordon D., Drummond, Rebecca A.
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Cells, 2022 In obesity, macrophage activation and infiltration in adipose tissue (AT) underlie chronic low-grade inflammation-induced insulin resistance. Although dectin-1 is primarily a pathogen recognition receptor and innate immune response modulator, its role in
Ashraf Al Madhoun +7 more
doaj +1 more source
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2
eLife, 2022 C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji +12 more
doaj +1 more source
Microbiome, 2022 Background Innate immunity genes have been reported to affect susceptibility to inflammatory bowel diseases (IBDs) and colitis in mice. Dectin-1, a receptor for fungal cell wall β-glucans, has been clearly implicated in gut microbiota modulation and ...
Yazhou Wang +11 more
doaj +1 more source