Dependence on Dectin-1 Varies With Multiple Candida Species [PDF]
Frontiers in Microbiology, 2019 Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs).
Aiysha Thompson +10 more
doaj +6 more sources
Dectin-1 Signaling Update: New Perspectives for Trained Immunity [PDF]
Frontiers in Immunology, 2022 The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses.
Pablo Mata-Martínez +2 more
doaj +5 more sources
Dectin-1-Independent Macrophage Phagocytosis of Mycobacterium abscessus. [PDF]
Int J Mol Sci, 2023 Mycobacterium abscessus, a species of nontuberculous mycobacteria (NTM), is an opportunistic pathogen that is readily cleared by healthy lungs but can cause pulmonary infections in people with chronic airway diseases. Although knowledge pertaining to molecular mechanisms of host defense against NTM is increasing, macrophage receptors that recognize M ...
Ochoa AE +6 more
europepmc +3 more sources
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency. [PDF]
Sci Adv, 2023 Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) cause immune dysregulation with autoimmunity, immunodeficiency and lymphoproliferation (IDAIL). Incomplete penetrance and variable expressivity are characteristic of IDAIL caused by CTLA-4 haploinsufficiency ...
Turnbull C +25 more
europepmc +7 more sources
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways
Cell Reports, 2015 Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer.
Lena Seifert +23 more
doaj +1 more source
Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88
Cell Reports, 2017 The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose ...
Angela Castoldi +25 more
doaj +1 more source
RHOA mediated mechanical force generation through Dectin-1 [PDF]
Journal of Cell Science, 2019 ABSTRACTDectin-1 is an innate immune pattern recognition receptor which recognizes β-glucan on theCandida albicans(C. albicans) cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine production.
Choraghe, Rohan P. +4 more
openaire +3 more sources
Expression of dectin-1 during fungus infection in human corneal epithelial cells
International Journal of Ophthalmology, 2014 AIM:To evaluate the expression of dendritic cell-associated C-type lectin-1 (dectin-1) in human corneal epithelial (HCE) cells infected by fungus.METHODS:A total of 20 cases of healthy donor corneas were group A, and 20 patients (20 eyes) suffered from ...
Cui Li +8 more
doaj +1 more source
1,25(OH)2D3 and VDR Signaling Pathways Regulate the Inhibition of Dectin-1 Caused by Cyclosporine A in Response to Aspergillus Fumigatus in Human Corneal Epithelial Cells. [PDF]
PLoS ONE, 2016 The objective of this study is to observe whether cyclosporine A (CsA) inhibits the expression of dectin-1 in human corneal epithelial cells infected with Aspergillus fumigatus (A.
Yiping Xia +7 more
doaj +1 more source
Frontiers in Immunology, 2021 The epithelium-associated cytokine thymic stromal lymphopoietin (TSLP) can induce OX40L and CCL17 expression by myeloid dendritic cells (mDCs), which contributes to aberrant Th2-type immune responses.
Chao Gu +13 more
doaj +1 more source