Results 11 to 20 of about 18,800 (200)

Dependence on Dectin-1 Varies With Multiple Candida Species [PDF]

Frontiers in Microbiology, 2019
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs).
Aiysha Thompson, Aiysha Thompson, James S. Griffiths, Louise Walker, Diogo M. da Fonseca, Keunsook K. Lee, Philip R. Taylor, Philip R. Taylor, Neil A. R. Gow, Neil A. R. Gow, Selinda J. Orr   +10 more
doaj   +6 more sources

Dectin-1-Independent Macrophage Phagocytosis of <i>Mycobacterium abscessus</i>. [PDF]

Int J Mol Sci, 2023
Mycobacterium abscessus, a species of nontuberculous mycobacteria (NTM), is an opportunistic pathogen that is readily cleared by healthy lungs but can cause pulmonary infections in people with chronic airway diseases. Although knowledge pertaining to molecular mechanisms of host defense against NTM is increasing, macrophage receptors that recognize M ...
Ochoa AE, Congel JH, Corley JM, Janssen WJ, Nick JA, Malcolm KC, Hisert KB.   +6 more
europepmc   +3 more sources

DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency. [PDF]

Sci Adv, 2023
Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) cause immune dysregulation with autoimmunity, immunodeficiency and lymphoproliferation (IDAIL). Incomplete penetrance and variable expressivity are characteristic of IDAIL caused by CTLA-4 haploinsufficiency ...
Turnbull C, Bones J, Stanley M, Medhavy A, Wang H, Lorenzo AMD, Cappello J, Shanmuganandam S, Pandey A, Seneviratne S, Brown GJ, Meng X, Fulcher D, Burgio G, Man SM, de Lucas Collantes C, Gasior M, López Granados E, Martin P, Jiang SH, Cook MC, Ellyard JI, Athanasopoulos V, Corry B, Canete PF, Vinuesa CG.   +25 more
europepmc   +7 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Dectin-1/IL-15 Pathway Affords Protection against Extrapulmonary Aspergillus fumigatus Infection by Regulating Natural Killer Cell Survival

Journal of Innate Immunity, 2023
Aspergillus fumigatus is a ubiquitous, yet potentially pathogenic, mold. The immune system employs innate receptors, such as dectin-1, to recognize fungal pathogens, but the immunological networks that afford protection are poorly explored.
Fábio S.Y. Yoshikawa, Maki Wakatsuki, Kosuke Yoshida, Rikio Yabe, Shota Torigoe, Sho Yamasaki, Glen N. Barber, Shinobu Saijo   +7 more
doaj   +1 more source

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

Cell Reports, 2015
Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity, but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer.
Lena Seifert, Michael Deutsch, Sara Alothman, Dalia Alqunaibit, Gregor Werba, Mridul Pansari, Matthew Pergamo, Atsuo Ochi, Alejandro Torres-Hernandez, Elliot Levie, Daniel Tippens, Stephanie H. Greco, Shaun Tiwari, Nancy Ngoc Giao Ly, Andrew Eisenthal, Eliza van Heerden, Antonina Avanzi, Rocky Barilla, Constantinos P. Zambirinis, Mauricio Rendon, Donnele Daley, H. Leon Pachter, Cristina Hajdu, George Miller   +23 more
doaj   +1 more source

Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]

, 2020
β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik, Bossier, Peter, Cox, Eric, Han, Biao, Vanrompay, Daisy   +4 more
core   +2 more sources

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]

, 2012
C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira, Anders, Bjorge, Camby, Caminschi, Christoph Römmele, Elola, Ferwerda, Geijtenbeek, Gingras, Gringhuis, Gross, Hans-Joachim Anders, Heil, Heni Eka Susanti, Hornung, Kimbrell, Kock, Kono, Kronin, Kulkarni, Lassen, Lech, Lech, Lech, Lopez-Guisa, Maciej Lech, Medzhitov, Mocsai, Osorio, Patole, Rakoff-Nahoum, Regina Gröbmayr, Roman Günthner, Schreibelt, Skuginna, Van Vliet, Wagner, Zarember, Zhang   +39 more
core   +5 more sources

Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection

Frontiers in Microbiology, 2021
More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to C.
Aiysha Thompson, Aiysha Thompson, Diogo M. da Fonseca, Diogo M. da Fonseca, Louise Walker, James S. Griffiths, James S. Griffiths, Philip R. Taylor, Philip R. Taylor, Neil A. R. Gow, Neil A. R. Gow, Selinda J. Orr, Selinda J. Orr   +12 more
doaj   +1 more source

RHOA mediated mechanical force generation through Dectin-1 [PDF]

Journal of Cell Science, 2019
ABSTRACTDectin-1 is an innate immune pattern recognition receptor which recognizes β-glucan on theCandida albicans(C. albicans) cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine production.
Choraghe, Rohan P., Kołodziej, Tomasz, Buser, Alan, Rajfur, Zenon, Neumann, Aaron K.   +4 more
openaire   +3 more sources