Results 21 to 30 of about 18,800 (200)

Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]

, 2013
Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V., Bratton, Donna L., Brown, Gordon D., Gow, Neil A. R., Leslie, Christina C., Mahaffey, Spencer, Murphy, Robert C., Silveira, Lori J., Suram, Saritha, Williams, David L.   +9 more
core   +16 more sources

Expression of dectin-1 during fungus infection in human corneal epithelial cells

International Journal of Ophthalmology, 2014
AIM:To evaluate the expression of dendritic cell-associated C-type lectin-1 (dectin-1) in human corneal epithelial (HCE) cells infected by fungus.METHODS:A total of 20 cases of healthy donor corneas were group A, and 20 patients (20 eyes) suffered from ...
Cui Li, Gui-Qiu Zhao, Cheng-Ye Che, Na Li, Jing Lin, Qiang Xu, Qian Wang, Ying Liu, Sheng Qiu   +8 more
doaj   +1 more source

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections [PDF]

New England Journal of Medicine, 2009
Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1.
Ferwerda, E.B., Ferwerda, G., Plantinga, T.S., Willment, J.A., van Spriel, A.B., Venselaar, H., Elbers, C.C., Johnson, M.D., Cambi, A., Huysamen, C., Jacobs, L., Jansen, T.J.G., Verheijen, K., Masthoff, L., Morre, S.A., Vriend, G., Williams, D.L., Perfect, J.R., Joosten, L.A.B., Joosten, L.A.B., Joosten, L.A.B., Wijmenga, C., van der Meer, J.W.M., Adema, G.J., Kullberg, B.J., Brown, G.D., Netea, M.G.   +26 more
openaire   +7 more sources

Dectin-1 Signaling Update: New Perspectives for Trained Immunity [PDF]

Frontiers in Immunology, 2022
The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses. However, over time, different ligands both of microbial-derived and endogenous origin have been shown to be recognized by Dectin-1.
Pablo Mata-Martínez, Marta Bergón-Gutiérrez, Carlos del Fresno   +2 more
openaire   +5 more sources

Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

PLoS Pathogens, 2011
C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of T(H)1 and T(H)-17 cellular responses.
Sonja I Gringhuis, Brigitte A Wevers, Tanja M Kaptein, Toni M M van Capel, Bart Theelen, Teun Boekhout, Esther C de Jong, Teunis B H Geijtenbeek   +7 more
doaj   +1 more source

Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis [PDF]

, 2012
We thank Dr. Cristina Massi Benedetti for digital art and editingRecognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses.
A de Luca, A Gales, A Puel, A Rivera, AM del Pilar Jimenez, B Ferwerda, B Martin, B Stockinger, C Cunha, C Qi, HM Lee, HR Conti, J Yano, JL Werner, JL Werner, JM Ramirez, L Romani, L Stejskalova, M Karababa, MA Gessner, MG Netea, NC Rogers, PR Taylor, PR Taylor, RA Drummond, RA Drummond, S Agrawal, S LeibundGut-Landmann, S Saijo, S Saijo, SC Cheng, SE Autenrieth, SE Heinsbroek, SE Heinsbroek, SI Gringhuis, T Liu, Teresa Zelante, TS Plantinga   +37 more
core   +1 more source

Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells

Frontiers in Immunology, 2021
The epithelium-associated cytokine thymic stromal lymphopoietin (TSLP) can induce OX40L and CCL17 expression by myeloid dendritic cells (mDCs), which contributes to aberrant Th2-type immune responses.
Chao Gu, Katherine Upchurch, Joshua Horton, Mathew Wiest, Mathew Wiest, Sandra Zurawski, Mark Millard, Robert R. Kane, Robert R. Kane, HyeMee Joo, HyeMee Joo, Lisa A. Miller, SangKon Oh, SangKon Oh   +13 more
doaj   +1 more source

Dectin‐1 promotes fungicidal activity of human neutrophils [PDF]

European Journal of Immunology, 2007
AbstractHuman polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease.
Kennedy, Adam D., Willment, Janet A., Dorward, David W., Williams, David L., Brown, Gordon D., DeLeo, Frank R.   +5 more
openaire   +3 more sources

Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice

mBio, 2013
We assessed the role of Dectin-1 in the immune response to the pathogenic fungus Coccidioides, both in vitro and in vivo, using mice with a targeted mutation in Clec7a.
Suganya Viriyakosol, Maria del Pilar Jimenez, Michael A. Gurney, Mark E. Ashbaugh, Joshua Fierer   +4 more
doaj   +1 more source

Dectin-1 and its role in antifungal immunity [PDF]

Medical Mycology, 2008
The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms.
Matti, Kimberg, Gordon D, Brown
openaire   +2 more sources