Results 21 to 30 of about 10,276 (160)

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections [PDF]

New England Journal of Medicine, 2009
Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1.
Ferwerda, E.B., Ferwerda, G., Plantinga, T.S., Willment, J.A., van Spriel, A.B., Venselaar, H., Elbers, C.C., Johnson, M.D., Cambi, A., Huysamen, C., Jacobs, L., Jansen, T.J.G., Verheijen, K., Masthoff, L., Morre, S.A., Vriend, G., Williams, D.L., Perfect, J.R., Joosten, L.A.B., Joosten, L.A.B., Joosten, L.A.B., Wijmenga, C., van der Meer, J.W.M., Adema, G.J., Kullberg, B.J., Brown, G.D., Netea, M.G.   +26 more
openaire   +7 more sources

Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection

Frontiers in Microbiology, 2021
More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to C.
Aiysha Thompson, Aiysha Thompson, Diogo M. da Fonseca, Diogo M. da Fonseca, Louise Walker, James S. Griffiths, James S. Griffiths, Philip R. Taylor, Philip R. Taylor, Neil A. R. Gow, Neil A. R. Gow, Selinda J. Orr, Selinda J. Orr   +12 more
doaj   +1 more source

Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

PLoS Pathogens, 2011
C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of T(H)1 and T(H)-17 cellular responses.
Sonja I Gringhuis, Brigitte A Wevers, Tanja M Kaptein, Toni M M van Capel, Bart Theelen, Teun Boekhout, Esther C de Jong, Teunis B H Geijtenbeek   +7 more
doaj   +1 more source

Dectin‐1 promotes fungicidal activity of human neutrophils [PDF]

European Journal of Immunology, 2007
AbstractHuman polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease.
Kennedy, Adam D., Willment, Janet A., Dorward, David W., Williams, David L., Brown, Gordon D., DeLeo, Frank R.   +5 more
openaire   +3 more sources

Dectin-1-Mediated DC-SIGN Recruitment to Candida albicans Contact Sites

Life, 2021
At host–pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C.
Rohan P. Choraghe, Aaron K. Neumann
doaj   +1 more source

Dectin-1 and its role in antifungal immunity [PDF]

Medical Mycology, 2008
The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms.
Matti, Kimberg, Gordon D, Brown
openaire   +2 more sources

Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice

mBio, 2013
We assessed the role of Dectin-1 in the immune response to the pathogenic fungus Coccidioides, both in vitro and in vivo, using mice with a targeted mutation in Clec7a.
Suganya Viriyakosol, Maria del Pilar Jimenez, Michael A. Gurney, Mark E. Ashbaugh, Joshua Fierer   +4 more
doaj   +1 more source

Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells

Frontiers in Immunology, 2018
We recently discovered that dectin-1-activated dendritic cells (DCs) drive potent T helper (Th) 9 cell responses and antitumor immunity. However, the underlying mechanisms need to be further defined.
Jintong Chen, Yinghua Zhao, Yuxue Jiang, Sujun Gao, Yiming Wang, Dongjiao Wang, Alison Wang, Huanfa Yi, Rui Gu, Qing Yi, Qing Yi, Siqing Wang   +11 more
doaj   +1 more source

Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.

PLoS ONE, 2012
The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi.
Juan Sainz, Carmen Belén Lupiáñez, Juana Segura-Catena, Lourdes Vazquez, Rafael Ríos, Salvador Oyonarte, Kari Hemminki, Asta Försti, Manuel Jurado   +8 more
doaj   +1 more source

Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy [PDF]

mSphere, 2019
The fungus Aspergillus fumigatus causes pulmonary invasive aspergillosis resulting in nearly 100,000 deaths each year. Patients are often treated with antifungal drugs such as amphotericin B (AmB) loaded into liposomes (AmB-LLs), but all antifungal drugs, including AmB-LLs, have serious ...
Suresh Ambati, Aileen R. Ferarro, S. Earl Kang, Jianfeng Lin, Xiaorong Lin, Michelle Momany, Zachary A. Lewis, Richard B. Meagher   +7 more
openaire   +3 more sources