Results 31 to 40 of about 18,800 (200)

Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells [PDF]

, 2014
β-glucans exert receptor-mediated immunomodulating activities, including oxidative burst activity and cytokine secretion. The role of the β-glucan receptors dectin-1 and complement receptor 3 (CR3) in the response of immune cells towards β-glucans is ...
Adachi, Adams, Bert Devriendt, Berton, Bose, Brown, Brown, Brown, Bruno M. Goddeeris, Dawson, Dominguez, Donne, Du, Eric Cox, Estrada, Eva Sonck, Gantner, Huang, Janeway, Kasorn, Kawai, Kim Baert, Kingeter, Lehne, Li, Lowell, Mair, Marakalala, Means, Miyanishi, Mocsai, Olynych, Parsons, Piriou-Guzylack, Qi, Ramberg, Reid, Rice, Ross, Ross, Sonck, Sonck, Taylor, Taylor, Thornton, Underhill, van Bruggen, Vetvicka, Williams, Willment, Willment, Xia, Yakubenko, Yokota, Yuan, Zimmerman   +55 more
core   +2 more sources

The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression [PDF]

, 2017
One of the major life-threatening infections for which severely immunocompromised patients are at risk is invasive aspergillosis (IA). Despite the current treatment options, the increasing antifungal resistance and poor outcome highlight the need for ...
Antachopoulos, Armstrong-James, Becker, Bellocchio, Bellocchio, Ben-Ami, Ben-Ami, Berrington, Bonnett, Bozza, Brock, Brown, Chai, Chamaillard, Chamilos, Chamilos, Chung, Cunha, Cunha, Drummond, Dubourdeau, Frutuoso, Galiger, Gantner, Gersuk, Gessner, Girardin, Gresnigt, Gresnigt, Gresnigt, Grube, Hohl, Joosten, Juarez, Kanayama, Kroll, Kyrmizi, Lamoth, Luther, Mehrad, Mencacci, Netea, Netea, Oosting, Opitz, Phadke, Philippe, Rodland, Said-Sadier, Sainz, Segal, Shepardson, Sprenkeler, Steele, Su, Tam, Underhill, Watanabe, Werner, Zhang   +59 more
core   +7 more sources

Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum.

PLoS Pathogens, 2017
Inflammasome is an intracellular protein complex that serves as cytosolic pattern recognition receptor (PRR) to engage with pathogens and to process cytokines of the interleukin-1 (IL-1) family into bioactive molecules.
Tzu-Hsuan Chang, Juin-Hua Huang, Hsiu-Chao Lin, Wen-Yu Chen, Yu-Hsiang Lee, Li-Chung Hsu, Mihai G Netea, Jenny P-Y Ting, Betty A Wu-Hsieh   +8 more
doaj   +1 more source

Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani [PDF]

, 2017
Purpose: Fusarium solani (F. solani) keratitis is a potentially sight-threatening fungal infection of the cornea. Antimicrobial peptides (AMPs), such as human β-defensins (hBDs) and cathelicidins, essential components of the immune system, likely have a ...
Baidouri, Hasna, Kolar, Satya Sree, McDermott, Alison   +2 more
core   +1 more source

Dectin-1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable Haemophilus influenzae

mBio, 2014
The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface
Kerstin A. Heyl, Tilman E. Klassert, Annina Heinrich, Mario M. Müller, Esther Klaile, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B. Singer, Hortense Slevogt   +9 more
doaj   +1 more source

Dectin-1-Mediated DC-SIGN Recruitment to Candida albicans Contact Sites

Life, 2021
At host–pathogen contact sites with Candida albicans, Dectin-1 activates pro-inflammatory signaling, while DC-SIGN promotes adhesion to the fungal surface. We observed that Dectin-1 and DC-SIGN collaborate to enhance capture/retention of C.
Rohan P. Choraghe, Aaron K. Neumann
doaj   +1 more source

Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]

, 2016
AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke, B Ferwerda, BN Gantner, C Kuei, CA Johnston, CA Munro, CA Rappleye, CJ Barelle, CJ Heilmann, DH Owen, DO Inglis, E Leberer, FN Gravelat, G Bindea, GD Brown, GJ Sosinska, HJ Flint, I Jacobs, ID Iliev, IV Ene, IV Ene, IV Ene, IV Ene, JE Nett, JM Bain, K Lemaire, LE Lewis, LM Graham, M Galán-Díez, M Karababa, M Santos, MG Netea, MG Netea, MJ Marakalala, MM Maidan, MT Kelly, N Vieira, NAR Gow, P Shannon, PR Desai, RA Hall, RT Wheeler, RT Wheeler, RT Wheeler, S Lev, S Shahana, SdJ Carrion, SE Hardison, SM Noble, TR O'Meara, YL Chen   +50 more
core   +1 more source

Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells

Frontiers in Immunology, 2018
We recently discovered that dectin-1-activated dendritic cells (DCs) drive potent T helper (Th) 9 cell responses and antitumor immunity. However, the underlying mechanisms need to be further defined.
Jintong Chen, Yinghua Zhao, Yuxue Jiang, Sujun Gao, Yiming Wang, Dongjiao Wang, Alison Wang, Huanfa Yi, Rui Gu, Qing Yi, Qing Yi, Siqing Wang   +11 more
doaj   +1 more source

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
core   +2 more sources

Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy [PDF]

mSphere, 2019
The fungus Aspergillus fumigatus causes pulmonary invasive aspergillosis resulting in nearly 100,000 deaths each year. Patients are often treated with antifungal drugs such as amphotericin B (AmB) loaded into liposomes (AmB-LLs), but all antifungal drugs, including AmB-LLs, have serious ...
Suresh Ambati, Aileen R. Ferarro, S. Earl Kang, Jianfeng Lin, Xiaorong Lin, Michelle Momany, Zachary A. Lewis, Richard B. Meagher   +7 more
openaire   +3 more sources