Results 31 to 40 of about 10,276 (160)

Dectin-1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable Haemophilus influenzae

mBio, 2014
The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface
Kerstin A. Heyl, Tilman E. Klassert, Annina Heinrich, Mario M. Müller, Esther Klaile, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B. Singer, Hortense Slevogt   +9 more
doaj   +1 more source

Genetic deletion of dectin-1 does not affect the course of murine experimental colitis

BMC Gastroenterology, 2012
Background It is believed that inflammatory bowel diseases (IBD) result from an imbalance in the intestinal immune response towards the luminal microbiome.
Heinsbroek Sigrid EM, Oei Anneke, Roelofs Joris JTH, Dhawan Shobhit, te Velde Anje, Gordon Siamon, de Jonge Wouter J   +6 more
doaj   +1 more source

Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease.

PLoS ONE, 2009
BackgroundDectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes beta-1,3 glucan, a polysaccharide and major component of the fungal cell wall.
Hilbert S de Vries, Theo S Plantinga, J Han van Krieken, Rinke Stienstra, Ad A van Bodegraven, Eleonora A M Festen, Rinse K Weersma, J Bart A Crusius, Ronald K Linskens, Leo A B Joosten, Mihai G Netea, Dirk J de Jong   +11 more
doaj   +1 more source

FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells

Frontiers in Immunology, 2017
The inhibitory effect of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcεRI γ-chain (FcRγ) has been found in many immune functions.
Yi-Gen Pan, Yen-Ling Yu, Chi-Chien Lin, Lewis L. Lanier, Lewis L. Lanier, Ching-Liang Chu   +5 more
doaj   +1 more source

Characterization of rat β‐glucan receptor dectin‐1 [PDF]

Microbiology and Immunology, 2008
ABSTRACTDectin‐1 is a small C‐type lectin receptor for fungal cell wall β‐glucan. Its homologues in some species, including mouse and human, have been characterized, and their importance in antifungal immunity has also been clarified. However, its homologue in the rat has not yet been identified.
Yuya, Kato, Yoshiyuki, Adachi, Naohito, Ohno   +2 more
openaire   +2 more sources

Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo

BMC Oral Health, 2022
Background Toll like receptors (TLR) 2 and 4 present on innate immune cells of the dental pulp detect cariogenic bacteria. Along with bacteria, C. albicans may also be present in dental caries. The presence of C.
Arshad Hasan, Talat Roome, Mohsin Wahid, Shazia Akbar Ansari, Hira Akhtar, Syeda Neha Ahmed Jilani, Amber Kiyani   +6 more
doaj   +1 more source

Pattern recognition: recent insights from Dectin-1

Current Opinion in Immunology, 2009
The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase,
Reid, Delyth M, Gow, Neil AR, Brown, Gordon D   +2 more
openaire   +2 more sources

MBL-mediated opsonophagocytosis of Candida albicans by human neutrophils is coupled with intracellular Dectin-1-triggered ROS production.

PLoS ONE, 2012
Mannan-binding lectin (MBL), a lectin homologous to C1q, greatly facilitates C3/C4-mediated opsonophagocytosis of Candida albicans (C. albicans) by human neutrophils, and has the capacity to bind to CR1 (CD35) expressed on circulating neutrophils.
Dongsheng Li, Bilin Dong, Zhongsheng Tong, Qinning Wang, Weihuang Liu, Yan Wang, Wei Liu, Jinbo Chen, Li Xu, Liuqing Chen, Yiqun Duan   +10 more
doaj   +1 more source

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1. [PDF]

PLoS ONE, 2017
Phagocytosis by innate immune cells is an important process for protection against multiple pathologies and is particularly important for resistance to infection.
Naomi M Walsh, Marcel Wuthrich, Huafeng Wang, Bruce Klein, Christina M Hull   +4 more
doaj   +1 more source

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source