Results 41 to 50 of about 10,276 (160)

Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity [PDF]

Frontiers in Immunology, 2018
One of the first steps toward mounting an effective immune response to Mycobacterium tuberculosis (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins ...
Wagener, M, Hoving, JC, Ndlovu, H, Marakalala, MJ   +3 more
openaire   +4 more sources

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway.

PLoS Pathogens, 2015
Collaboration between heterogeneous pattern recognition receptors (PRRs) leading to synergistic coordination of immune response is important for the host to fight against invading pathogens.
Juin-Hua Huang, Ching-Yu Lin, Sheng-Yang Wu, Wen-Yu Chen, Ching-Liang Chu, Gordon D Brown, Chih-Pin Chuu, Betty A Wu-Hsieh   +7 more
doaj   +1 more source

One‐Stone‐Three‐Birds Biomimetic Oral Targeting Delivery Strategy for On‐Demand Controlled Drug Release and Intervertebral Disc Degeneration Therapy

Exploration, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a multifactorial condition characterized by excessive inflammation, immune dysfunction, and metabolic disorders. Current therapeutic strategies primarily rely on local injection, a traumatic approach associated with risks of tissue damage and infection.
Yifan Ding, Yixin Cai, Weizhen Pan, Na Hu, Yunyun Wang, Huan Wang, Huang Fang, Songwei Tan, Zhiping Zhang   +8 more
wiley   +1 more source

Dectin‐1 mediates zymosan responses in microglia

The FASEB Journal, 2007
Microglia are the major immune component of brain that play a central role in neuroinflammation. Microglia are normally quiescent but are rapidly activated in response to pathogens as well as physical, chemical, or ischemic injuries. Zymosan, a β‐glucan‐containing particle derived from yeast cell wall, is commonly used to activate microglia in ...
Vaibhav Shah, Yongcheng Huang, Lakhu Keshvara   +2 more
openaire   +1 more source

Internalization of Dectin‐1 terminates induction of inflammatory responses [PDF]

European Journal of Immunology, 2009
AbstractDectin‐1 is a pattern‐recognition receptor recognizing β‐(1,3)‐glucans found on fungal cell walls. Dectin‐1 plays an important role in immunity to fungi by mediating phagocytic clearance of fungal particles and inducing transcription of innate response genes.
Hernanz-Falcón, Patricia, Joffre, Olivier, Williams, David L., Reis e Sousa, Caetano   +3 more
openaire   +3 more sources

Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression

Nature Communications, 2023
The effect of β-glucans and their receptor Dectin-1 in tumor development remains controversial. Here the authors show that Dectin-1 signaling promotes the development of colorectal cancer (CRC) by inducing prostaglandin E2 production in myeloid-derived ...
Ce Tang, Haiyang Sun, Motohiko Kadoki, Wei Han, Xiaoqi Ye, Yulia Makusheva, Jianping Deng, Bingbing Feng, Ding Qiu, Ying Tan, Xinying Wang, Zehao Guo, Chanyan Huang, Sui Peng, Minhu Chen, Yoshiyuki Adachi, Naohito Ohno, Sergio Trombetta, Yoichiro Iwakura   +18 more
doaj   +1 more source

Update on diagnosis, nonpharmacological treatment and prevention of Equine Gastric Ulcer Syndrome (EGUS)

Equine Veterinary Education, EarlyView.
Summary The term Equine Gastric Ulcer Syndrome (EGUS) has been used since 1999. As there are important differences, the terms Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD) were introduced in 2015. Risk factors like dietary management, training regimens and drug side effects, as described for NSAIDs, predispose ...
R. Lensing, A. K. Barton
wiley   +1 more source

Co-regulation of Dectin-1 and TLR2 in inflammatory response of human corneal epithelial cells induced by Aspergillus fumigates [PDF]

International Journal of Ophthalmology, 2016
AIM: To investigate the co-regulation of dendritic cell-associated C-type lectin-1 (Dectin-1), Toll-like receptor 2 (TLR2), and relative chemotactic factors in the Telomease-immortalized human corneal epithelial (THCE) cells after exposure to Aspergillus
Gui-Qiu Zhao, Xue-Yan Qiu, Jing Lin, Qing Li, Li-Ting Hu, Qian Wang, Hui Li   +6 more
doaj   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source