Results 41 to 50 of about 18,800 (200)
RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis [PDF]
, 2017 Cryptococcus neoformans , the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells.
Doering, Tamara L +4 more
core +2 more sources
Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.
PLoS ONE, 2012 The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi.
Juan Sainz +8 more
doaj +1 more source
Genetic deletion of dectin-1 does not affect the course of murine experimental colitis
BMC Gastroenterology, 2012 Background It is believed that inflammatory bowel diseases (IBD) result from an imbalance in the intestinal immune response towards the luminal microbiome.
Heinsbroek Sigrid EM +6 more
doaj +1 more source
Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst [PDF]
, 2014 Macrophages are vital to innate immunity and express pattern recognition receptors and integrins for the rapid detection of invading pathogens. Stimulation of Dectin-1 and complement receptor 3 (CR3) activates Erk- and Akt-dependent production of ...
Chan, Rebecca J. +9 more
core +2 more sources
PLoS ONE, 2016 BackgroundThe objective of this study is to observe whether cyclosporine A (CsA) inhibits the expression of dectin-1 in human corneal epithelial cells infected with Aspergillus fumigatus (A.
Yiping Xia +7 more
doaj +1 more source
Duality of β-glucan microparticles: antigen carrier and immunostimulants [PDF]
, 2016 Designing efficient recombinant mucosal vaccines against enteric diseases is still a major challenge. Mucosal delivery of recombinant vaccines requires encapsulation in potent immunostimulatory particles to induce an efficient immune response. This paper
Baert, Kim +4 more
core +2 more sources
Characterization of rat β‐glucan receptor dectin‐1 [PDF]
Microbiology and Immunology, 2008 ABSTRACTDectin‐1 is a small C‐type lectin receptor for fungal cell wall β‐glucan. Its homologues in some species, including mouse and human, have been characterized, and their importance in antifungal immunity has also been clarified. However, its homologue in the rat has not yet been identified.
Yuya, Kato +2 more
openaire +2 more sources
FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells
Frontiers in Immunology, 2017 The inhibitory effect of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcεRI γ-chain (FcRγ) has been found in many immune functions.
Yi-Gen Pan +5 more
doaj +1 more source
Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]
, 2017 This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N +5 more
core +1 more source
Pattern recognition: recent insights from Dectin-1
Current Opinion in Immunology, 2009 The beta-glucan receptor Dectin-1 is an archetypical non-toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production. Recent identification of the components of these signalling pathways, such as Syk kinase,
Reid, Delyth M +2 more
openaire +2 more sources