SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of Diabetic Patients [PDF]
Cells, 2022 The C-type lectin receptors (CLRs) Dectin-1 and Dectin-2 are involved in several innate immune responses and are expressed mainly in dendritic cells, monocytes, and macrophages.
Mohammed J. A. Haider +4 more
doaj +5 more sources
Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection [PDF]
Frontiers in Microbiology, 2021 More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to C.
Aiysha Thompson +12 more
doaj +9 more sources
The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan [PDF]
mBio, 2023 Aspergillus fumigatus is a ubiquitous environmental mold that causes significant mortality particularly among immunocompromised patients. The detection of the Aspergillus-derived carbohydrate galactomannan in patient serum and bronchoalveolar lavage ...
Jennifer L. Reedy +13 more
doaj +7 more sources
Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2. [PDF]
PLoS Pathogens, 2019 Candida albicans is one of the top leading causes of healthcare-associated bloodstream infection. Neutrophil extracellular traps (NET) are known to capture and kill pathogens. It is reported that opsonized C.
Sheng-Yang Wu +6 more
doaj +6 more sources
Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice [PDF]
Microbiome, 2022 Background Innate immunity genes have been reported to affect susceptibility to inflammatory bowel diseases (IBDs) and colitis in mice. Dectin-1, a receptor for fungal cell wall β-glucans, has been clearly implicated in gut microbiota modulation and ...
Yazhou Wang +11 more
doaj +3 more sources
Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis [PDF]
Frontiers in ImmunologyIntroductionThe emerging fungal pathogen Sporothrix brasiliensis has been responsible for epidemic outbursts of sporotrichosis in Latin America, particularly Brazil, in recent years.
Fabio Seiti Yamada Yoshikawa +2 more
doaj +3 more sources
Contribution of CARD9 signaling to wound healing in skin promoted by topical administration of heat-killed Enterococcus faecalis strain KH2 and the involvement of Dectin-2 [PDF]
Frontiers in ImmunologyIntroductionLactic acid bacteria (LAB) are well known for their beneficial effects on the regulation of immune responses and host protection against microbial infections.
Shiho Kurosaka +22 more
doaj +3 more sources
Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination. [PDF]
PLoS Pathogens, 2017 The development of vaccines against fungi and other intracellular microbes is impeded in part by a lack of suitable adjuvants. While most current vaccines against infectious diseases preferentially induce production of antibodies, cellular immunity is ...
Huafeng Wang +8 more
doaj +4 more sources
Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum. [PDF]
PLoS Pathogens, 2017 Inflammasome is an intracellular protein complex that serves as cytosolic pattern recognition receptor (PRR) to engage with pathogens and to process cytokines of the interleukin-1 (IL-1) family into bioactive molecules.
Tzu-Hsuan Chang +8 more
doaj +2 more sources
Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients [PDF]
Journal of Biomedical Science, 2019 Background Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodies (MoAbs) attenuates HDM ...
Ming-Han Chen +7 more
doaj +2 more sources