The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity. [PDF]
EMBO RepThe ability of myeloid cells to recognize and differentiate endogenous or exogenous ligands rely on the presence of different transmembrane protein receptors.
Malamud M, Brown GD.
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D-galacto-D-mannan-mediated Dectin-2 activation orchestrates potent cellular and humoral immunity as a viral vaccine adjuvant. [PDF]
Front ImmunolIntroduction Conventional foot-and-mouth disease (FMD) vaccines have been developed to enhance their effectiveness; however, several drawbacks remain, such as slow induction of antibody titers, short-lived immune response, and local side effects at the ...
Kim HW +9 more
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Interactions that define the arrangement of sugar-binding sites in BDCA-2 and dectin-2 dimers. [PDF]
GlycobiologyThe sugar-binding receptors dectin-2 and blood dendritic cell antigen 2 (BDCA-2) bind oligosaccharide ligands through extracellular carbohydrate-recognition domains (CRDs) and initiate intracellular signaling through Fc receptor γ adapters (FcRγ). Dectin-
Liu Y +6 more
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Evid Based Complement Alternat Med, 2022 Background Inflammatory responses are involved in ischemic injuries and cardiac repair after acute myocardial infarction (AMI). Dectin-2 is a C-type lectin receptor that induces cytokine production and promotes local inflammatory responses. Methods Sixty
Feng W, Wang Z, Shi L.
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C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells. [PDF]
PLoS ONE, 2017 C-type lectin receptors (CLRs) recognize pathogen-derived ligands and abnormal self that trigger protective immune responses. However, the precise nature of self ligands recognized by CLRs remains to be determined. Here, we found that Dectin-2 recognizes
Daiki Mori +2 more
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CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection. [PDF]
J Immunol, 2020 Key Points IL-17A is critical for GCP-rCpa1 vaccine–mediated protection against Coccidioides. GCP-rCpa1 is recognized by macrophages expressing Dectin-1 and Dectin-2.
Campuzano A +9 more
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Information transfer in mammalian glycan-based communication
eLife, 2023 Glycan-binding proteins, so-called lectins, are exposed on mammalian cell surfaces and decipher the information encoded within glycans translating it into biochemical signal transduction pathways in the cell.
Felix F Fuchsberger +6 more
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Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2
eLife, 2022 C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji +12 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
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Involvement of Dectin-2 in Ultraviolet Radiation-Induced Tolerance [PDF]
The Journal of Immunology, 2003 Abstract Hapten sensitization through UV-exposed skin induces hapten-specific tolerance which can be adoptively transferred by injecting T cells into naive recipients. The exact phenotype of the regulatory T cells responsible for inhibiting the immune response and their mode of action remain largely unclear.
Yoshinori, Aragane +5 more
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