Results 41 to 50 of about 22,245,271 (149)

Dectin-1 and Dectin-2 in innate immunity against fungi [PDF]

International Immunology, 2011
Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. Dectin-1 recognizes β-glucans with its CRD and transduces signals through its immunoreceptor tyrosine-based activation motif
Shinobu, Saijo, Yoichiro, Iwakura
openaire   +2 more sources

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes [PDF]

Journal of Experimental Medicine, 2011
The innate signaling pathways for Th2 immunity activated by inhaled antigens are not well defined. We previously identified Dectin-2 as a receptor for glycans in allergen extracts from the house dust mite Dermatophagoides farinae (Df) that mediates cysteinyl leukotriene (cys-LT) generation from pulmonary CD11c+ cells and from GM-CSF–cultured bone ...
Barrett, Nora A., Rahman, Opu M., Fernandez, James M., Parsons, Matthew W., Xing, Wei, Austen, K. Frank, Kanaoka, Yoshihide   +6 more
openaire   +2 more sources

The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis. [PDF]

J Interferon Cytokine Res, 2016
Despite the fact that Candida albicans is an important human fungal pathogen and Dectin-2 is a major pattern recognition receptor for fungi, our knowledge regarding the role of Dectin-2 for the host defense against disseminated candidiasis is limited.
Ifrim DC, Quintin J, Courjol F, Verschueren I, van Krieken JH, Koentgen F, Fradin C, Gow NA, Joosten LA, van der Meer JW, van de Veerdonk F, Netea MG.   +11 more
europepmc   +8 more sources

Epidermal Langerhans Cell-Targeted Gene Expression by a Dectin-2 Promoter [PDF]

The Journal of Immunology, 2001
AbstractDespite their critical function as APCs for primary immune responses, dendritic cells (DC) and Langerhans cells (LC) have been rarely used as targets of gene-based manipulation because well-defined regulatory elements controlling LC/DC-specific expression have not been identified.
M, Bonkobara, P K, Zukas, S, Shikano, S, Nakamura, P D, Cruz, K, Ariizumi   +5 more
openaire   +2 more sources

Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo

BMC Oral Health, 2022
Background Toll like receptors (TLR) 2 and 4 present on innate immune cells of the dental pulp detect cariogenic bacteria. Along with bacteria, C. albicans may also be present in dental caries. The presence of C.
Arshad Hasan, Talat Roome, Mohsin Wahid, Shazia Akbar Ansari, Hira Akhtar, Syeda Neha Ahmed Jilani, Amber Kiyani   +6 more
doaj   +1 more source

Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria [PDF]

Immunity, 2014
Mycobacteria possess various immunomodulatory molecules on the cell wall. Mannose-capped lipoarabinomannan (Man-LAM), a major lipoglycan of Mycobacterium tuberculosis, has long been known to have both inhibitory and stimulatory effects on host immunity.
Yonekawa, Akiko, Saijo, Shinobu, Hoshino, Yoshihiko, Miyake, Yasunobu, Ishikawa, Eri, Suzukawa, Maho, Inoue, Hiromasa, Tanaka, Masato, Yoneyama, Mitsutoshi, Oh-hora, Masatsugu, Akashi, Koichi, Yamasaki, Sho   +11 more
openaire   +2 more sources

Involvement of Dectin-2 in the Innate Inflammatory Response Triggered by Influenza Virus Hemagglutinin

Advances in Infectious Diseases, 2023
C-type lectin receptors (CLRs) are representative pattern recognition receptors that recognize microbial polysaccharides expressed on antigen-presenting cells. In the present study, we carried out further detailed analysis on the involvement of Dectin-2,
Hideki Yamamoto, Chikako Tomiyama, Sho Yamasaki, S. Saijo, Y. Iwakura, K. Kawakami   +5 more
semanticscholar   +1 more source

Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

PLoS Pathogens, 2011
C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of T(H)1 and T(H)-17 cellular responses.
Sonja I Gringhuis, Brigitte A Wevers, Tanja M Kaptein, Toni M M van Capel, Bart Theelen, Teun Boekhout, Esther C de Jong, Teunis B H Geijtenbeek   +7 more
doaj   +1 more source

Dectin-2 polymorphism associated with pulmonary cryptococcosis in HIV-uninfected Chinese patients [PDF]

Medical Mycology, 2015
Dectin-2 is a C-type lectin receptor that can recognize critical structures of fungi and involve in the host immune response after pulmonary fungal infections. We aimed to investigate the association between Dectin-2 genetic polymorphisms and cryptococcosis among a series of human immunodeficiency virus (HIV)-uninfected Chinese patients.
Xiu-Ping, Hu, Rui-Ying, Wang, Xuan, Wang, Ya-Hui, Cao, Yan-Qiong, Chen, Hua-Zhen, Zhao, Ji-Qin, Wu, Xin-Hua, Weng, Xin-Hua, Gao, Ren-Hua, Sun, Li-Ping, Zhu   +10 more
openaire   +2 more sources

Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine. [PDF]

PLoS ONE, 2013
Although thymus-independent type 2 antigens generally do not undergo Ig class switching from IgM to IgG, pneumococcal polysaccharide vaccine (PPV) induces the production of serotype-specific IgG. How this happens remains unclear, however.
Tomomitsu Miyasaka, Yukiko Akahori, Masahiko Toyama, Namiko Miyamura, Keiko Ishii, Shinobu Saijo, Yoichiro Iwakura, Yuki Kinjo, Yoshitsugu Miyazaki, Kazunori Oishi, Kazuyoshi Kawakami   +10 more
doaj   +1 more source