Results 51 to 60 of about 22,245,271 (149)

Transcriptional Regulation of Dectin-2 Promoter in Transgenic Mouse

Journal of Veterinary Medical Science, 2004
Despite a preeminent role of epidermal Langerhans cells (LC) in inducing primary immunity, application of gene-based modification to LC function is limited by lack of well-defined transcription regulatory units that can direct LC-specific gene expression.
Makoto, Bonkobara, Tatsuo, Yudate, Hiroko, Yagihara, Tsukimi, Washizu, Ponciano D, Cruz, Kiyoshi, Ariizumi   +5 more
openaire   +3 more sources

The Dectin-2 family of C-type lectin-like receptors: an update [PDF]

International Immunology, 2013
Myeloid and non-myeloid cells express members of the C-type lectin-like receptor (CTLR) family, which mediate crucial cellular functions during immunity and homeostasis. Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell immunoactivating ...
Kerscher, Bernhard, Willment, Janet A., Brown, Gordon D.   +2 more
openaire   +3 more sources

Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation.

PLoS ONE, 2012
We have re-investigated the role of the complement system and the non-opsonic pattern recognition receptors dectin-1 and dectin-2 in the recognition of fungal particles by inflammatory neutrophils, monocytes and macrophages.
Jacqueline U McDonald, Marcela Rosas, Gordon D Brown, Simon A Jones, Philip R Taylor   +4 more
doaj   +1 more source

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1. [PDF]

PLoS ONE, 2017
Phagocytosis by innate immune cells is an important process for protection against multiple pathologies and is particularly important for resistance to infection.
Naomi M Walsh, Marcel Wuthrich, Huafeng Wang, Bruce Klein, Christina M Hull   +4 more
doaj   +1 more source

Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae [PDF]

BMC Immunology, 2016
Streptococcus pneumoniae, a major causative bacterial pathogen of community-acquired pneumonia, possesses a thick polysaccharide capsule. Host defense against this bacterium is mediated by activation of innate immune cells that sense bacterial components.
Akahori, Yukiko, Miyasaka, Tomomitsu, Toyama, Masahiko, Matsumoto, Ikumi, Miyahara, Anna, Zong, Tong, Ishii, Keiko, Kinjo, Yuki, Miyazaki, Yoshitsugu, Saijo, Shinobu, Iwakura, Yoichiro, Kawakami, Kazuyoshi   +11 more
openaire   +2 more sources

Role of Dectin-2 for Host Defense against Systemic Infection with Candida glabrata [PDF]

Infection and Immunity, 2014
ABSTRACTAlthoughCandida glabratais an important pathogenicCandidaspecies, relatively little is known about its innate immune recognition. Here, we explore the potential role of Dectin-2 for host defense againstC. glabrata. Dectin-2-deficient (Dectin-2−/−) mice were found to be more susceptible toC.
Ifrim, D.C., Ifrim, D.C., Bain, J.M., Reid, D.M., Oosting, M., Oosting, M., Oosting, M., Verschueren, I., Verschueren, I., Gow, N.A., van Krieken, J.H.J.M., van Krieken, J.H.J.M., Brown, G.D., Kullberg, B.J., Kullberg, B.J., Joosten, L.A.B., Joosten, L.A.B., Joosten, L.A.B., van der Meer, J.W.M., van der Meer, J.W.M., Koentgen, F., Erwig, L.P., Quintin, J., Quintin, J., Netea, M.G., Netea, M.G.   +25 more
openaire   +5 more sources

Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism [PDF]

Clinical and Experimental Immunology, 2017
Summary Uveitis (intraocular inflammation) is a leading cause of loss of vision. Although its aetiology is largely speculative, it is thought to arise from complex genetic–environmental interactions that break immune tolerance to generate eye-specific autoreactive T cells.
B R Brown, E J Lee, P E Snow, E E Vance, Y Iwakura, N Ohno, N Miura, X Lin, G D Brown, C A Wells, J R Smith, R R Caspi, H L Rosenzweig   +12 more
openaire   +3 more sources

Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2. [PDF]

Sci Rep, 2019
Human thioredoxin (hTrx), which can be secreted from cells upon stress, functions in allergic skin inflammation as a T cell antigen due to homology and cross-reactivity with the fungal allergen Mala s13 of the skin-colonizing yeast Malassezia sympodialis.
Roesner LM, Ernst M, Chen W, Begemann G, Kienlin P, Raulf MK, Lepenies B, Werfel T.   +7 more
europepmc   +2 more sources

Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice

mBio, 2013
We assessed the role of Dectin-1 in the immune response to the pathogenic fungus Coccidioides, both in vitro and in vivo, using mice with a targeted mutation in Clec7a.
Suganya Viriyakosol, Maria del Pilar Jimenez, Michael A. Gurney, Mark E. Ashbaugh, Joshua Fierer   +4 more
doaj   +1 more source

Cryptococcus gattii alters immunostimulatory potential in response to the environment.

PLoS ONE, 2019
Cryptococcus gattii is a capsular fungal pathogen, which causes life-threatening cryptococcosis in immunocompetent individuals. This emerging pathogen is less likely to be recognized by innate immunity compared to traditional Cryptococcus neoformans ...
Keigo Ueno, Yoshiko Otani, Nao Yanagihara, Takumi Nakamura, Kiminori Shimizu, Satoshi Yamagoe, Yoshitsugu Miyazaki   +6 more
doaj   +1 more source